Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Evan P. Gallagher

Using Salmonid Microarrays to Understand the Dietary Modulation of Carcinogenesis in Rainbow Trout
Toxicol. Sci. 2006 90: 1-4; doi:10.1093/toxsci/kfj093 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW:

Niranjali Gamage, Amanda Barnett, Nadine Hempel, Ronald G. Duggleby, Kelly F. Windmill, Jennifer L. Martin, and Michael E. McManus

Human Sulfotransferases and Their Role in Chemical Metabolism
ToxSci Advance Access published on December 1, 2005
Toxicol. Sci. 2006 90: 5-22; doi:10.1093/toxsci/kfj061 [Abstract] [Full Text] [PDF] Supplementary DataSupplementary Data [Request Permissions]  

FORUM SERIES:

Paul Borm, Frederick C. Klaessig, Timothy D. Landry, Brij Moudgil, Jürgen Pauluhn, Karluss Thomas, Remi Trottier, and Stewart Wood

Research Strategies for Safety Evaluation of Nanomaterials, Part V: Role of Dissolution in Biological Fate and Effects of Nanoscale Particles
ToxSci Advance Access published on January 4, 2006
Toxicol. Sci. 2006 90: 23-32; doi:10.1093/toxsci/kfj084 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM:

Werner K. Lutz, Roman W. Lutz, and Melvin E. Andersen

Dose-Incidence Relationships Derived from Superposition of Distributions of Individual Susceptibility on Mechanism-Based Dose Responses for Biological Effects
ToxSci Advance Access published on October 19, 2005
Toxicol. Sci. 2006 90: 33-38; doi:10.1093/toxsci/kfj026 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Christiana Hofmann, Christian Pütz, Brigitte Semder, Thomas H. Faller, György A. Csanády, and Johannes G. Filser

Styrene-7,8-Oxide Burden in Ventilated, Perfused Lungs of Mice and Rats Exposed to Vaporous Styrene
ToxSci Advance Access published on December 1, 2005
Toxicol. Sci. 2006 90: 39-48; doi:10.1093/toxsci/kfj056 [Abstract] [Full Text] [PDF] [Request Permissions]  

Balázs Németi, Iván Csanaky, and Zoltán Gregus

Effect of an Inactivator of Glyceraldehyde-3-Phosphate Dehydrogenase, a Fortuitous Arsenate Reductase, on Disposition of Arsenate in Rats
ToxSci Advance Access published on December 1, 2005
Toxicol. Sci. 2006 90: 49-60; doi:10.1093/toxsci/kfj058 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Susan C. Tilton, Scott A. Givan, Cliff B. Pereira, George S. Bailey, and David E. Williams

Toxicogenomic Profiling of the Hepatic Tumor Promoters Indole-3-Carbinol, 17ß-Estradiol and ß-Naphthoflavone in Rainbow Trout
ToxSci Advance Access published on September 28, 2005
Toxicol. Sci. 2006 90: 61-72; doi:10.1093/toxsci/kfi341 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Jui-I Chao, Shih-Hsin Hsu, and Tsui-Chun Tsou

Depletion of Securin Increases Arsenite-Induced Chromosome Instability and Apoptosis via a p53-Independent Pathway
ToxSci Advance Access published on December 7, 2005
Toxicol. Sci. 2006 90: 73-86; doi:10.1093/toxsci/kfj070 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Jeffrey W. Fisher, Jerry Campbell, Srinivasa Muralidhara, James V. Bruckner, Duncan Ferguson, Moiz Mumtaz, Barry Harmon, Joan M. Hedge, Kevin M. Crofton, Hekap Kim, and Tara L. Almekinder

Effect of PCB 126 on Hepatic Metabolism of Thyroxine and Perturbations in the Hypothalamic-Pituitary-Thyroid Axis in the Rat
ToxSci Advance Access published on December 9, 2005
Toxicol. Sci. 2006 90: 87-95; doi:10.1093/toxsci/kfj069 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Silvia Diani-Moore, Erin Labitzke, Richard Brown, Alexander Garvin, Linda Wong, and Arleen B. Rifkind

Sunlight Generates Multiple Tryptophan Photoproducts Eliciting High Efficacy CYP1A Induction in Chick Hepatocytes and In Vivo
ToxSci Advance Access published on December 5, 2005
Toxicol. Sci. 2006 90: 96-110; doi:10.1093/toxsci/kfj065 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Takashi Umemura, Yuichi Kuroiwa, Yasuki Kitamura, Yuji Ishii, Keita Kanki, Yukio Kodama, Ken Itoh, Masayuki Yamamoto, Akiyoshi Nishikawa, and Masao Hirose

A Crucial Role of Nrf2 in In Vivo Defense against Oxidative Damage by an Environmental Pollutant, Pentachlorophenol
ToxSci Advance Access published on December 13, 2005
Toxicol. Sci. 2006 90: 111-119; doi:10.1093/toxsci/kfj076 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY:

Ozgur Kutuk, Giuseppe Poli, and Huveyda Basaga

Resveratrol Protects Against 4-Hydroxynonenal-Induced Apoptosis by Blocking JNK and c-JUN/AP-1 Signaling
ToxSci Advance Access published on December 1, 2005
Toxicol. Sci. 2006 90: 120-132; doi:10.1093/toxsci/kfj055 [Abstract] [Full Text] [PDF] [Request Permissions]  

Toshihiko Kasahara, Kazuo Tomita, Hiroyuki Murano, Tsuyoshi Harada, Keisuke Tsubakimoto, Takuo Ogihara, Syuhei Ohnishi, and Chihaya Kakinuma

Establishment of an In Vitro High-Throughput Screening Assay for Detecting Phospholipidosis-Inducing Potential
ToxSci Advance Access published on December 7, 2005
Toxicol. Sci. 2006 90: 133-141; doi:10.1093/toxsci/kfj067 [Abstract] [Full Text] [PDF] [Request Permissions]  

Leonard T. Rael, Felix Ayala-Fierro, Raphael Bar-Or, Dean E. Carter, and David S. Barber

Interaction of Arsine with Hemoglobin in Arsine-Induced Hemolysis
ToxSci Advance Access published on December 1, 2005
Toxicol. Sci. 2006 90: 142-148; doi:10.1093/toxsci/kfj054 [Abstract] [Full Text] [PDF] [Request Permissions]  

Khuram W. Chaudhary, Nestor X. Barrezueta, Mary B. Bauchmann, Anthony J. Milici, Gretchen Beckius, Donald B. Stedman, John E. Hambor, William L. Blake, John D. McNeish, Anthony Bahinski, and Gabriela Gebrin Cezar

Embryonic Stem Cells in Predictive Cardiotoxicity: Laser Capture Microscopy Enables Assay Development
ToxSci Advance Access published on December 15, 2005
Toxicol. Sci. 2006 90: 149-158; doi:10.1093/toxsci/kfj078 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Donna W. Lee, Robert M. Gelein, and Lisa A. Opanashuk

Heme-Oxygenase-1 Promotes Polychlorinated Biphenyl Mixture Aroclor 1254-Induced Oxidative Stress and Dopaminergic Cell Injury
ToxSci Advance Access published on November 30, 2005
Toxicol. Sci. 2006 90: 159-167; doi:10.1093/toxsci/kfj052 [Abstract] [Full Text] [PDF] [Request Permissions]  

Anabel Pérez-Gómez, Amaia Ferrero-Gutierrez, Antonello Novelli, José M. Franco, Beatriz Paz, and M. Teresa Fernández-Sánchez

Potent Neurotoxic Action of the Shellfish Biotoxin Yessotoxin on Cultured Cerebellar Neurons
ToxSci Advance Access published on December 1, 2005
Toxicol. Sci. 2006 90: 168-177; doi:10.1093/toxsci/kfj064 [Abstract] [Full Text] [PDF] [Request Permissions]  

Karen Lau, W. Graham McLean, Dominic P. Williams, and C. Vyvyan Howard

Synergistic Interactions between Commonly Used Food Additives in a Developmental Neurotoxicity Test
ToxSci Advance Access published on December 13, 2005
Toxicol. Sci. 2006 90: 178-187; doi:10.1093/toxsci/kfj073 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Dale W. Porter, Lyndell L. Millecchia, Patsy Willard, Victor A. Robinson, Dawn Ramsey, Jeffery McLaurin, Amir Khan, Kurt Brumbaugh, Christoper M. Beighley, Alexander Teass, and Vincent Castranova

Nitric Oxide and Reactive Oxygen Species Production Causes Progressive Damage in Rats after Cessation of Silica Inhalation
ToxSci Advance Access published on December 9, 2005
Toxicol. Sci. 2006 90: 188-197; doi:10.1093/toxsci/kfj075 [Abstract] [Full Text] [PDF] [Request Permissions]  

Jeffry D. Schroeter, Julia S. Kimbell, Anna M. Bonner, Kay C. Roberts, Melvin E. Andersen, and David C. Dorman

Incorporation of Tissue Reaction Kinetics in a Computational Fluid Dynamics Model for Nasal Extraction of Inhaled Hydrogen Sulfide in Rats
ToxSci Advance Access published on December 12, 2005
Toxicol. Sci. 2006 90: 198-207; doi:10.1093/toxsci/kfj072 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Sarah E. Ali-Khan and Barbara F. Hales

Retinoid Receptor Antagonists Alter the Pattern of Apoptosis in Organogenesis Stage Mouse Limbs
ToxSci Advance Access published on December 1, 2005
Toxicol. Sci. 2006 90: 208-220; doi:10.1093/toxsci/kfj060 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Hua Jin, Soon-Kyung Hwang, Kyungnam Yu, Hanjo K. Anderson, Yeon-Sook Lee, Kee Ho Lee, Anne-Catherine Prats, Dominique Morello, George R. Beck, Jr., and Myung-Haing Cho

A High Inorganic Phosphate Diet Perturbs Brain Growth, Alters Akt-ERK Signaling, and Results in Changes in Cap-Dependent Translation
ToxSci Advance Access published on December 7, 2005
Toxicol. Sci. 2006 90: 221-229; doi:10.1093/toxsci/kfj066 [Abstract] [Full Text] [PDF] [Request Permissions]  

Nicole V. Soucy, Horace D. Parkinson, Mark A. Sochaski, and Susan J. Borghoff

Kinetics of Genistein and Its Conjugated Metabolites in Pregnant Sprague-Dawley Rats Following Single and Repeated Genistein Administration
ToxSci Advance Access published on December 13, 2005
Toxicol. Sci. 2006 90: 230-240; doi:10.1093/toxsci/kfj077 [Abstract] [Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

Salomon Sand, Dietrich von Rosen, Katarina Victorin, and Agneta Falk Filipsson

Identification of a Critical Dose Level for Risk Assessment: Developments in Benchmark Dose Analysis of Continuous Endpoints
ToxSci Advance Access published on December 1, 2005
Toxicol. Sci. 2006 90: 241-251; doi:10.1093/toxsci/kfj057 [Abstract] [Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Andre Silvanovich, Margaret A. Nemeth, Ping Song, Rod Herman, Laura Tagliani, and Gary A. Bannon

The Value of Short Amino Acid Sequence Matches for Prediction of Protein Allergenicity
ToxSci Advance Access published on December 7, 2005
Toxicol. Sci. 2006 90: 252-258; doi:10.1093/toxsci/kfj068 [Abstract] [Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Leonardo A. M. Zornoff, Luiz S. Matsubara, Beatriz B. Matsubara, Marina P. Okoshi, Katashi Okoshi, Maeli Dal Pai-Silva, Robson F. Carvalho, Antonio C. Cicogna, Carlos R. Padovani, Ethel L. Novelli, Rosangela Novo, Álvaro O. Campana, and Sergio A. R. Paiva

Beta-Carotene Supplementation Attenuates Cardiac Remodeling Induced by One-Month Tobacco-Smoke Exposure in Rats
ToxSci Advance Access published on December 30, 2005
Toxicol. Sci. 2006 90: 259-266; doi:10.1093/toxsci/kfj080 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

ERRATA:

ERRATUM
Toxicol. Sci. 2006 90: 267; doi:10.1093/toxsci/kfj079 [Extract] [Full Text] [PDF] [Request Permissions]  

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