Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Michael A. Lynes and Xiuyun Yin

Metallothionein and Anti-Metallothionein, Complementary Elements of Cadmium-Induced Renal Disease
Toxicol. Sci. 2006 91: 1-3; doi:10.1093/toxsci/kfj149 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW:

Michael P. Holsapple, David Jones, Thomas T. Kawabata, Ian Kimber, Kathy Sarlo, MaryJane K. Selgrade, Jui Shah, and Michael R. Woolhiser

Assessing the Potential to Induce Respiratory Hypersensitivity
ToxSci Advance Access published on December 9, 2005
Toxicol. Sci. 2006 91: 4-13; doi:10.1093/toxsci/kfj074 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM SERIES:

Treye Thomas, Karluss Thomas, Nakissa Sadrieh, Nora Savage, Patricia Adair, and Robert Bronaugh

Research Strategies for Safety Evaluation of Nanomaterials, Part VII: Evaluating Consumer Exposure to Nanoscale Materials
ToxSci Advance Access published on February 13, 2006
Toxicol. Sci. 2006 91: 14-19; doi:10.1093/toxsci/kfj129 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM:

Thomas B. Starr, Genevieve Matanoski, M. W. Anders, and Melvin E. Andersen

Workshop Overview: Reassessment of the Cancer Risk of Dichloromethane in Humans
ToxSci Advance Access published on February 28, 2006
Toxicol. Sci. 2006 91: 20-28; doi:10.1093/toxsci/kfj145 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Yasong Lu, Manupat Lohitnavy, Micaela B. Reddy, Ornrat Lohitnavy, Amanda Ashley, and Raymond S. H. Yang

An Updated Physiologically Based Pharmacokinetic Model for Hexachlorobenzene: Incorporation of Pathophysiological States following Partial Hepatectomy and Hexachlorobenzene Treatment
ToxSci Advance Access published on February 15, 2006
Toxicol. Sci. 2006 91: 29-41; doi:10.1093/toxsci/kfj133 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Jing-Fen Han, Shou-Lin Wang, Xiao-Yang He, Chun-Yong Liu, and Jun-Yan Hong

Effect of Genetic Variation on Human Cytochrome P450 Reductase-Mediated Paraquat Cytotoxicity
ToxSci Advance Access published on February 22, 2006
Toxicol. Sci. 2006 91: 42-48; doi:10.1093/toxsci/kfj139 [Abstract] [Full Text] [PDF] [Request Permissions]  

Ute M. D. Schauer, Wolfgang Völkel, and Wolfgang Dekant

Toxicokinetics of Tetrabromobisphenol A in Humans and Rats after Oral Administration
ToxSci Advance Access published on February 15, 2006
Toxicol. Sci. 2006 91: 49-58; doi:10.1093/toxsci/kfj132 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Xukun Deng, Fangzhou Yin, Xiaoyu Lu, Baochang Cai, and Wu Yin

The Apoptotic Effect of Brucine from the Seed of Strychnos nux-vomica on Human Hepatoma Cells is Mediated via Bcl-2 and Ca²⁺ Involved Mitochondrial Pathway
ToxSci Advance Access published on January 27, 2006
Toxicol. Sci. 2006 91: 59-69; doi:10.1093/toxsci/kfj114 [Abstract] [Full Text] [PDF] [Request Permissions]  

Chikara Kojima, Wei Qu, Michael P. Waalkes, Seiichiro Himeno, and Teruaki Sakurai

Chronic Exposure to Methylated Arsenicals Stimulates Arsenic Excretion Pathways and Induces Arsenic Tolerance in Rat Liver Cells
ToxSci Advance Access published on January 25, 2006
Toxicol. Sci. 2006 91: 70-81; doi:10.1093/toxsci/kfj117 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Angeliki Lyssimachou, Bjørn Munro Jenssen, and Augustine Arukwe

Brain Cytochrome P450 Aromatase Gene Isoforms and Activity Levels in Atlantic Salmon After Waterborne Exposure to Nominal Environmental Concentrations of the Pharmaceutical Ethynylestradiol and Antifoulant Tributyltin
ToxSci Advance Access published on February 16, 2006
Toxicol. Sci. 2006 91: 82-92; doi:10.1093/toxsci/kfj136 [Abstract] [Full Text] [PDF] [Request Permissions]  

Xiao-Juan Wang, Erika Bartolucci-Page, Suzanne E. Fenton, and Li You

Altered Mammary Gland Development in Male Rats Exposed to Genistein and Methoxychlor
ToxSci Advance Access published on January 27, 2006
Toxicol. Sci. 2006 91: 93-103; doi:10.1093/toxsci/kfj120 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Liang Chen, Taiyi Jin, Bo Huang, Xiuli Chang, Lijian Lei, Gunnar F. Nordberg, and Monica Nordberg

Plasma Metallothionein Antibody and Cadmium-Induced Renal Dysfunction in an Occupational Population in China
ToxSci Advance Access published on December 1, 2005
Toxicol. Sci. 2006 91: 104-112; doi:10.1093/toxsci/kfj053 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

IMMUNOTOXIOCOLOGY:

John B. Carey, Ashley Allshire, and Frank N. van Pelt

Immune Modulation by Cadmium and Lead in the Acute Reporter Antigen–Popliteal Lymph Node Assay
ToxSci Advance Access published on February 22, 2006
Toxicol. Sci. 2006 91: 113-122; doi:10.1093/toxsci/kfj142 [Abstract] [Full Text] [PDF] [Request Permissions]  

Sang-Hyun Kim, Chang-Duk Jun, Kyongho Suk, Byung-Ju Choi, Hyunjeung Lim, Seunja Park, Seung Ho Lee, Hye-Young Shin, Dae-Keun Kim, and Tae-Yong Shin

Gallic Acid Inhibits Histamine Release and Pro-inflammatory Cytokine Production in Mast Cells
ToxSci Advance Access published on December 1, 2005
Toxicol. Sci. 2006 91: 123-131; doi:10.1093/toxsci/kfj063 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY:

Huijun Zhu and Nigel J. Gooderham

Mechanisms of Induction of Cell Cycle Arrest and Cell Death by Cryptolepine in Human Lung Adenocarcinoma A549 Cells
ToxSci Advance Access published on March 1, 2006
Toxicol. Sci. 2006 91: 132-139; doi:10.1093/toxsci/kfj146 [Abstract] [Full Text] [PDF] [Request Permissions]  

Katrin Letschert, Heinz Faulstich, Daniela Keller, and Dietrich Keppler

Molecular Characterization and Inhibition of Amanitin Uptake into Human Hepatocytes
ToxSci Advance Access published on February 22, 2006
Toxicol. Sci. 2006 91: 140-149; doi:10.1093/toxsci/kfj141 [Abstract] [Full Text] [PDF] [Request Permissions]  

Leonardo M. Pérez, Piotr Milkiewicz, Elwyn Elias, Roger Coleman, Enrique J. Sánchez Pozzi, and Marcelo G. Roma

Oxidative Stress Induces Internalization of the Bile Salt Export Pump, Bsep, and Bile Salt Secretory Failure in Isolated Rat Hepatocyte Couplets: A Role for Protein Kinase C and Prevention by Protein Kinase A
ToxSci Advance Access published on February 1, 2006
Toxicol. Sci. 2006 91: 150-158; doi:10.1093/toxsci/kfj113 [Abstract] [Full Text] [PDF] [Request Permissions]  

Jessica P. Ryman-Rasmussen, Jim E. Riviere, and Nancy A. Monteiro-Riviere

Penetration of Intact Skin by Quantum Dots with Diverse Physicochemical Properties
ToxSci Advance Access published on January 27, 2006
Toxicol. Sci. 2006 91: 159-165; doi:10.1093/toxsci/kfj122 [Abstract] [Full Text] [PDF] [Request Permissions]  

Gary B. Quistad, Shannon N. Liang, Karl J. Fisher, Daniel K. Nomura, and John E. Casida

Each Lipase Has a Unique Sensitivity Profile for Organophosphorus Inhibitors
ToxSci Advance Access published on January 31, 2006
Toxicol. Sci. 2006 91: 166-172; doi:10.1093/toxsci/kfj124 [Abstract] [Full Text] [PDF] Supplementary DataSupplementary Data [Request Permissions]  

Aleksandra Isakovic, Zoran Markovic, Biljana Todorovic-Markovic, Nadezda Nikolic, Sanja Vranjes-Djuric, Marija Mirkovic, Miroslav Dramicanin, Ljubica Harhaji, Nevena Raicevic, Zoran Nikolic, and Vladimir Trajkovic

Distinct Cytotoxic Mechanisms of Pristine versus Hydroxylated Fullerene
ToxSci Advance Access published on February 13, 2006
Toxicol. Sci. 2006 91: 173-183; doi:10.1093/toxsci/kfj127 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Lucila Aimo and Patricia I. Oteiza

Zinc Deficiency Increases the Susceptibility of Human Neuroblastoma Cells to Lead-Induced Activator Protein-1 Activation
ToxSci Advance Access published on February 16, 2006
Toxicol. Sci. 2006 91: 184-191; doi:10.1093/toxsci/kfj137 [Abstract] [Full Text] [PDF] [Request Permissions]  

Cheng Wang, Natalya Sadovova, Charlotte Hotchkiss, Xin Fu, Andrew C. Scallet, Tucker A. Patterson, Joseph Hanig, Merle G. Paule, and William Slikker, Jr.

Blockade of N-Methyl-D-Aspartate Receptors by Ketamine Produces Loss of Postnatal Day 3 Monkey Frontal Cortical Neurons in Culture
ToxSci Advance Access published on February 24, 2006
Toxicol. Sci. 2006 91: 192-201; doi:10.1093/toxsci/kfj144 [Abstract] [Full Text] [PDF] [Request Permissions]  

Niladri Basu, Anton M. Scheuhammer, Kirsti Rouvinen-Watt, Nicole Grochowina, Kate Klenavic, R. Douglas Evans, and Hing Man Chan

Methylmercury Impairs Components of the Cholinergic System in Captive Mink (Mustela vison)
ToxSci Advance Access published on January 30, 2006
Toxicol. Sci. 2006 91: 202-209; doi:10.1093/toxsci/kfj121 [Abstract] [Full Text] [PDF] [Request Permissions]  

Matilde López-Grancha, Carmen Sánchez-Amate, Montserrat Navarro, Francisca Carvajal, Fernando Sánchez-Santed, and Inmaculada Cubero

Lateral Parabrachial Lesions Disrupt Paraoxon-Induced Conditioned Flavor Avoidance
ToxSci Advance Access published on February 13, 2006
Toxicol. Sci. 2006 91: 210-217; doi:10.1093/toxsci/kfj126 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Hirotoshi Shima, Eiko Koike, Ritsuko Shinohara, and Takahiro Kobayashi

Oxidative Ability and Toxicity of n-Hexane Insoluble Fraction of Diesel Exhaust Particles
ToxSci Advance Access published on January 27, 2006
Toxicol. Sci. 2006 91: 218-226; doi:10.1093/toxsci/kfj119 [Abstract] [Full Text] [PDF] [Request Permissions]  

David B. Warheit, Thomas R. Webb, Christie M. Sayes, Vicki L. Colvin, and Kenneth L. Reed

Pulmonary Instillation Studies with Nanoscale TiO₂ Rods and Dots in Rats: Toxicity Is not Dependent upon Particle Size and Surface Area
ToxSci Advance Access published on February 22, 2006
Toxicol. Sci. 2006 91: 227-236; doi:10.1093/toxsci/kfj140 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Daniel L. Costa, James R. Lehmann, Darrell Winsett, Judy Richards, Allen D. Ledbetter, and Kevin L. Dreher

Comparative Pulmonary Toxicological Assessment of Oil Combustion Particles Following Inhalation or Instillation Exposure
ToxSci Advance Access published on January 31, 2006
Toxicol. Sci. 2006 91: 237-246; doi:10.1093/toxsci/kfj123 [Abstract] [Full Text] [PDF] [Request Permissions]  

Simone Wichert Grande, Anderson J. M. Andrade, Chris E. Talsness, Konstanze Grote, and Ibrahim Chahoud

A Dose-Response Study Following In Utero and Lactational Exposure to Di(2-ethylhexyl)phthalate: Effects on Female Rat Reproductive Development
ToxSci Advance Access published on February 13, 2006
Toxicol. Sci. 2006 91: 247-254; doi:10.1093/toxsci/kfj128 [Abstract] [Full Text] [PDF] [Request Permissions]  

Stephanie A. Lahousse, Stephanie A. Beall, and Kamin J. Johnson

Mono-(2-ethylhexyl) Phthalate Rapidly Increases Celsr2 Protein Phosphorylation in HeLa Cells via Protein Kinase C and Casein Kinase 1
ToxSci Advance Access published on February 16, 2006
Toxicol. Sci. 2006 91: 255-264; doi:10.1093/toxsci/kfj135 [Abstract] [Full Text] [PDF] [Request Permissions]  

Ryuta Ishimura, Takashige Kawakami, Seiichiroh Ohsako, Keiko Nohara, and Chiharu Tohyama

Suppressive Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Vascular Remodeling That Takes Place in the Normal Labyrinth Zone of Rat Placenta during Late Gestation
ToxSci Advance Access published on February 22, 2006
Toxicol. Sci. 2006 91: 265-274; doi:10.1093/toxsci/kfj138 [Abstract] [Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

Robert A. Budinsky, Dennis Paustenbach, Donald Fontaine, Bryce Landenberger, and Thomas B. Starr

Recommended Relative Potency Factors for 2,3,4,7,8-Pentachlorodibenzofuran: The Impact of Different Dose Metrics
ToxSci Advance Access published on February 2, 2006
Toxicol. Sci. 2006 91: 275-285; doi:10.1093/toxsci/kfj125 [Abstract] [Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Jeffrey W. Allen, Patrick W. Mantyh, Kjersti Horais, Nicole Tozier, Scott D. Rogers, Joseph R. Ghilardi, Dasa Cizkova, Marjorie R. Grafe, Phillip Richter, Douglas A. Lappi, and Tony L. Yaksh

Safety Evaluation of Intrathecal Substance P-Saporin, a Targeted Neurotoxin, in Dogs
ToxSci Advance Access published on February 24, 2006
Toxicol. Sci. 2006 91: 286-298; doi:10.1093/toxsci/kfj143 [Abstract] [Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Jianxun Xie and Zahir A. Shaikh

Cadmium-Induced Apoptosis in Rat Kidney Epithelial Cells Involves Decrease in Nuclear Factor-Kappa B Activity
ToxSci Advance Access published on February 14, 2006
Toxicol. Sci. 2006 91: 299-308; doi:10.1093/toxsci/kfj131 [Abstract] [Full Text] [PDF] [Request Permissions]  

COMMENT:

Lora C. Robosky, Dale F. Wells, Laura A. Egnash, Matthew L. Manning, Michael D. Reily, and Donald G. Robertson

Communication Regarding Metabonomic Identification of Two Distinct Phenotypes in Sprague-Dawley (Crl:CD(SD)) Rats
ToxSci Advance Access published on February 16, 2006
Toxicol. Sci. 2006 91: 309; doi:10.1093/toxsci/kfj134 [Extract] [Full Text] [PDF] [Request Permissions]  

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