Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Owen R. Moss

Site-Specific, Dose-Dependent Transitional Analysis of Toxicologic Mechanisms: The Interplay of Local Metabolic and Physicochemical Saturation
Toxicol. Sci. 2006 91: 311-312; doi:10.1093/toxsci/kfj188 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW:

Edward A. Lock and Celia J. Reed

Trichloroethylene: Mechanisms of Renal Toxicity and Renal Cancer and Relevance to Risk Assessment
ToxSci Advance Access published on January 18, 2006
Toxicol. Sci. 2006 91: 313-331; doi:10.1093/toxsci/kfj107 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Per Ewing, Bo Blomgren, Åke Ryrfeldt, and Per Gerde

Increasing Exposure Levels Cause an Abrupt Change in the Absorption and Metabolism of Acutely Inhaled Benzo(a)pyrene in the Isolated, Ventilated, and Perfused Lung of the Rat
ToxSci Advance Access published on January 16, 2006
Toxicol. Sci. 2006 91: 332-340; doi:10.1093/toxsci/kfj104 [Abstract] [Full Text] [PDF] [Request Permissions]  

William J. Fasano, Stephen C. Carpenter, Shawn A. Gannon, Timothy A. Snow, Judith C. Stadler, Gerald L. Kennedy, Robert C. Buck, Stephen H. Korzeniowski, Paul M. Hinderliter, and Raymond A. Kemper

Absorption, Distribution, Metabolism, and Elimination of 8-2 Fluorotelomer Alcohol in the Rat
ToxSci Advance Access published on March 16, 2006
Toxicol. Sci. 2006 91: 341-355; doi:10.1093/toxsci/kfj160 [Abstract] [Full Text] [PDF] [Request Permissions]  

Yong Liu, Jiang-Wei Zhang, Wei Li, Hong Ma, Jie Sun, Mai-Cun Deng, and Ling Yang

Ginsenoside Metabolites, Rather Than Naturally Occurring Ginsenosides, Lead to Inhibition of Human Cytochrome P450 Enzymes
ToxSci Advance Access published on March 17, 2006
Toxicol. Sci. 2006 91: 356-364; doi:10.1093/toxsci/kfj164 [Abstract] [Full Text] [PDF] [Request Permissions]  

Jingxiang Bai and Arthur I. Cederbaum

Adenovirus-Mediated Expression of CYP2E1 Produces Liver Toxicity in Mice
ToxSci Advance Access published on March 20, 2006
Toxicol. Sci. 2006 91: 365-371; doi:10.1093/toxsci/kfj165 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Xing Cui, Toshifumi Wakai, Yoshio Shirai, Katsuyoshi Hatakeyama, and Seishiro Hirano

Chronic Oral Exposure to Inorganic Arsenate Interferes with Methylation Status of p16^INK4a and RASSF1A and Induces Lung Cancer in A/J Mice
ToxSci Advance Access published on March 16, 2006
Toxicol. Sci. 2006 91: 372-381; doi:10.1093/toxsci/kfj159 [Abstract] [Full Text] [PDF] [Request Permissions]  

Yaeno Arima, Chikako Nishigori, Toru Takeuchi, Shigenori Oka, Kanehisa Morimoto, Atsushi Utani, and Yoshiki Miyachi

4-Nitroquinoline 1-Oxide Forms 8-Hydroxydeoxyguanosine in Human Fibroblasts through Reactive Oxygen Species
ToxSci Advance Access published on March 17, 2006
Toxicol. Sci. 2006 91: 382-392; doi:10.1093/toxsci/kfj161 [Abstract] [Full Text] [PDF] [Request Permissions]  

Ammie N. Bachman, Jennifer M. Phillips, and Jay I. Goodman

Phenobarbital Induces Progressive Patterns of GC-Rich and Gene-Specific Altered DNA Methylation in the Liver of Tumor-Prone B6C3F1 Mice
ToxSci Advance Access published on March 14, 2006
Toxicol. Sci. 2006 91: 393-405; doi:10.1093/toxsci/kfj155 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Ammie N. Bachman, Geoffrey M. Curtin, David J. Doolittle, and Jay I. Goodman

Altered Methylation in Gene-Specific and GC-Rich Regions of DNA Is Progressive and Nonrandom during Promotion of Skin Tumorigenesis
ToxSci Advance Access published on March 28, 2006
Toxicol. Sci. 2006 91: 406-418; doi:10.1093/toxsci/kfj179 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Seiichi Katayama, Koji Ashizawa, Tadahiro Fukuhara, Makoto Hiroyasu, Yasuhiro Tsuzuki, Hideki Tatemoto, Tadashi Nakada, and Kenji Nagai

Differential Expression Patterns of Wnt and ß-Catenin/TCF Target Genes in the Uterus of Immature Female Rats Exposed to 17-Ethynyl Estradiol
ToxSci Advance Access published on March 21, 2006
Toxicol. Sci. 2006 91: 419-430; doi:10.1093/toxsci/kfj167 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Mathilakath M. Vijayan, Neelakanteswar Aluru, Alec G. Maule, and Even H. Jørgensen

Fasting Augments PCB Impact on Liver Metabolism in Anadromous Arctic Char
ToxSci Advance Access published on March 14, 2006
Toxicol. Sci. 2006 91: 431-439; doi:10.1093/toxsci/kfj154 [Abstract] [Full Text] [PDF] [Request Permissions]  

M. S. Shailaja, Rani Rajamanickam, and Solimabi Wahidulla

Formation of Genotoxic Nitro-PAH Compounds in Fish Exposed to Ambient Nitrite and PAH
ToxSci Advance Access published on March 10, 2006
Toxicol. Sci. 2006 91: 440-447; doi:10.1093/toxsci/kfj151 [Abstract] [Full Text] [PDF] [Request Permissions]  

Xunshan Ding, Kristin Lichti, and Jeff L. Staudinger

The Mycoestrogen Zearalenone Induces CYP3A through Activation of the Pregnane X Receptor
ToxSci Advance Access published on March 17, 2006
Toxicol. Sci. 2006 91: 448-455; doi:10.1093/toxsci/kfj163 [Abstract] [Full Text] [PDF] [Request Permissions]  

Tiina F. M. Mikkilä, Jorma Toppari, and Jorma Paranko

Effects of Neonatal Exposure to 4-Tert-Octylphenol, Diethylstilbestrol, and Flutamide on Steroidogenesis in Infantile Rat Testis
ToxSci Advance Access published on March 14, 2006
Toxicol. Sci. 2006 91: 456-466; doi:10.1093/toxsci/kfj156 [Abstract] [Full Text] [PDF] [Request Permissions]  

Xu Dong Zhou, Donald A. Sens, Mary Ann Sens, Venugopal B. R. K. Namburi, Rajendra K. Singh, Scott H. Garrett, and Seema Somji

Metallothionein-1 and -2 Expression in Cadmium- or Arsenic-Derived Human Malignant Urothelial Cells and Tumor Heterotransplants and as a Prognostic Indicator in Human Bladder Cancer
ToxSci Advance Access published on March 24, 2006
Toxicol. Sci. 2006 91: 467-475; doi:10.1093/toxsci/kfj174 [Abstract] [Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY:

Jun Cao, Li Jia, Hui-Min Zhou, Yong Liu, and Lai-Fu Zhong

Mitochondrial and Nuclear DNA Damage Induced by Curcumin in Human Hepatoma G2 Cells
ToxSci Advance Access published on March 14, 2006
Toxicol. Sci. 2006 91: 476-483; doi:10.1093/toxsci/kfj153 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

IN VITRO TOXICOLOGY:

Mathieu Vinken, Tom Henkens, Tamara Vanhaecke, Peggy Papeleu, Albert Geerts, Elke Van Rossen, James Kevin Chipman, Paolo Meda, and Vera Rogiers

Trichostatin A Enhances Gap Junctional Intercellular Communication in Primary Cultures of Adult Rat Hepatocytes
ToxSci Advance Access published on March 10, 2006
Toxicol. Sci. 2006 91: 484-492; doi:10.1093/toxsci/kfj152 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Manish M. Tiwari, Kurt J. Messer, and Philip R. Mayeux

Inducible Nitric Oxide Synthase and Apoptosis in Murine Proximal Tubule Epithelial Cells
ToxSci Advance Access published on March 21, 2006
Toxicol. Sci. 2006 91: 493-500; doi:10.1093/toxsci/kfj168 [Abstract] [Full Text] [PDF] [Request Permissions]  

Géraldine Lemaire, Wissem Mnif, Jean-Marc Pascussi, Arnaud Pillon, Fanja Rabenoelina, Hélène Fenet, Elena Gomez, Claude Casellas, Jean-Claude Nicolas, Vincent Cavaillès, Marie-Josèphe Duchesne, and Patrick Balaguer

Identification of New Human Pregnane X Receptor Ligands among Pesticides Using a Stable Reporter Cell System
ToxSci Advance Access published on March 24, 2006
Toxicol. Sci. 2006 91: 501-509; doi:10.1093/toxsci/kfj173 [Abstract] [Full Text] [PDF] [Request Permissions]  

Zoé Elias, Odile Poirot, Ivana Fenoglio, Mara Ghiazza, Marie–Céleste Danière, Francine Terzetti, Christian Darne, Catherine Coulais, Ildiko Matekovits, and Bice Fubini

Surface Reactivity, Cytotoxic, and Morphological Transforming Effects of Diatomaceous Earth Products in Syrian Hamster Embryo Cells
ToxSci Advance Access published on March 29, 2006
Toxicol. Sci. 2006 91: 510-520; doi:10.1093/toxsci/kfj177 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

NEUROTOXICOLOGY:

Xuhong Liu, Kelly A. Sullivan, James E. Madl, Marie Legare, and Ronald B. Tjalkens

Manganese-Induced Neurotoxicity: The Role of Astroglial-Derived Nitric Oxide in Striatal Interneuron Degeneration
ToxSci Advance Access published on March 21, 2006
Toxicol. Sci. 2006 91: 521-531; doi:10.1093/toxsci/kfj150 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Ming-Kai Chen and Tomás R. Guilarte

Imaging the Peripheral Benzodiazepine Receptor Response in Central Nervous System Demyelination and Remyelination
ToxSci Advance Access published on March 22, 2006
Toxicol. Sci. 2006 91: 532-539; doi:10.1093/toxsci/kfj172 [Abstract] [Full Text] [PDF] [Request Permissions]  

Laszlo Vutskits, Eduardo Gascon, Edomer Tassonyi, and Jozsef Z. Kiss

Effect of Ketamine on Dendritic Arbor Development and Survival of Immature GABAergic Neurons In Vitro
ToxSci Advance Access published on March 31, 2006
Toxicol. Sci. 2006 91: 540-549; doi:10.1093/toxsci/kfj180 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Ramadoss Sivakumar, Puliyangudi Balakrishnan Sivaraman, Narayanasami Mohan-Babu, Ibrahim Mohamed Jainul-Abideen, Perumal Kalliyappan, and Karundevi Balasubramanian

Radiation Exposure Impairs Luteinizing Hormone Signal Transduction and Steroidogenesis in Cultured Human Leydig Cells
ToxSci Advance Access published on March 28, 2006
Toxicol. Sci. 2006 91: 550-556; doi:10.1093/toxsci/kfj178 [Abstract] [Full Text] [PDF] [Request Permissions]  

Twanda L. Thirkill, Hemamalini Vedagiri, and Gordon C. Douglas

Macaque Trophoblast Migration toward RANTES Is Inhibited by Cigarette Smoke–Conditioned Medium
ToxSci Advance Access published on March 2, 2006
Toxicol. Sci. 2006 91: 557-567; doi:10.1093/toxsci/kfj147 [Abstract] [Full Text] [PDF] [Request Permissions]  

Hanna M. Miettinen, Rita Sorvari, Satu Alaluusua, Mari Murtomaa, Juha Tuukkanen, and Matti Viluksela

The Effect of Perinatal TCDD Exposure on Caries Susceptibility in Rats
ToxSci Advance Access published on March 16, 2006
Toxicol. Sci. 2006 91: 568-575; doi:10.1093/toxsci/kfj158 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

RISK ASSESSMENT:

Peter Martinus Jozef Bos, Marco Jacob Zeilmaker, and Jan Cornelis Henri van Eijkeren

Application of Physiologically Based Pharmacokinetic Modeling in Setting Acute Exposure Guideline Levels for Methylene Chloride
ToxSci Advance Access published on March 28, 2006
Toxicol. Sci. 2006 91: 576-585; doi:10.1093/toxsci/kfj176 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

SAFETY EVALUATION:

Wendy G. Halpern, Patrick Lappin, Thomas Zanardi, Wendy Cai, Marta Corcoran, John Zhong, and Kevin P. Baker

Chronic Administration of Belimumab, a BLyS Antagonist, Decreases Tissue and Peripheral Blood B-Lymphocyte Populations in Cynomolgus Monkeys: Pharmacokinetic, Pharmacodynamic, and Toxicologic Effects
ToxSci Advance Access published on March 3, 2006
Toxicol. Sci. 2006 91: 586-599; doi:10.1093/toxsci/kfj148 [Abstract] [Full Text] [PDF] [Request Permissions]  

J. Enrique Cometto-Muñiz, William S. Cain, Michael H. Abraham, and Ricardo Sánchez-Moreno

Chemical Boundaries for Detection of Eye Irritation in Humans from Homologous Vapors
ToxSci Advance Access published on March 16, 2006
Toxicol. Sci. 2006 91: 600-609; doi:10.1093/toxsci/kfj157 [Abstract] [Full Text] [PDF] [Request Permissions]  

Rebecca L. Sheets, Judith Stein, T. Scott Manetz, Chris Duffy, Martha Nason, Charla Andrews, Wing-Pui Kong, Gary J. Nabel, and Phillip L. Gomez

Biodistribution of DNA Plasmid Vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile Virus Is Similar, without Integration, despite Differing Plasmid Backbones or Gene Inserts
ToxSci Advance Access published on March 28, 2006
Toxicol. Sci. 2006 91: 610-619; doi:10.1093/toxsci/kfj169 [Abstract] [Full Text] [PDF] [Request Permissions]  

Rebecca L. Sheets, Judith Stein, T. Scott Manetz, Charla Andrews, Robert Bailer, John Rathmann, and Phillip L. Gomez

Toxicological Safety Evaluation of DNA Plasmid Vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile Virus Is Similar Despite Differing Plasmid Backbones or Gene-Inserts
ToxSci Advance Access published on March 28, 2006
Toxicol. Sci. 2006 91: 620-630; doi:10.1093/toxsci/kfj170 [Abstract] [Full Text] [PDF] [Request Permissions]  

Steven Cooper, John R. Latendresse, Daniel R. Doerge, Nathan C. Twaddle, Xin Fu, and K. Barry Delclos

Dietary Modulation of p-Nonylphenol–Induced Polycystic Kidneys in Male Sprague-Dawley Rats
ToxSci Advance Access published on March 22, 2006
Toxicol. Sci. 2006 91: 631-642; doi:10.1093/toxsci/kfj171 [Abstract] [Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Jason M. Hansen, Hong Zhang, and Dean P. Jones

Mitochondrial Thioredoxin-2 Has a Key Role in Determining Tumor Necrosis Factor-–Induced Reactive Oxygen Species Generation, NF-B Activation, and Apoptosis
ToxSci Advance Access published on March 30, 2006
Toxicol. Sci. 2006 91: 643-650; doi:10.1093/toxsci/kfj175 [Abstract] [Full Text] [PDF] [Request Permissions]  

Takayoshi Nishiya, Hiroko Kataoka, Kazuhiko Mori, Mayumi Goto, Tadaki Sugawara, and Kazuhisa Furuhama

Tienilic Acid Enhances Hyperbilirubinemia in Eisai Hyperbilirubinuria Rats through Hepatic Multidrug Resistance–Associated Protein 3 and Heme Oxygenase-1 Induction
ToxSci Advance Access published on March 16, 2006
Toxicol. Sci. 2006 91: 651-659; doi:10.1093/toxsci/kfj162 [Abstract] [Full Text] [PDF] [Request Permissions]  

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