Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Caren M. Villano and Lori A. White

The Aryl Hydrocarbon Receptor–Signaling Pathway and Tissue Remodeling: Insights from the Zebrafish (Danio rerio) Model System
Toxicol. Sci. 2006 92: 1-4; doi:10.1093/toxsci/kfj215 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW:

Ken Donaldson, Robert Aitken, Lang Tran, Vicki Stone, Rodger Duffin, Gavin Forrest, and Andrew Alexander

Carbon Nanotubes: A Review of Their Properties in Relation to Pulmonary Toxicology and Workplace Safety
ToxSci Advance Access published on February 16, 2006
Toxicol. Sci. 2006 92: 5-22; doi:10.1093/toxsci/kfj130 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM:

Karluss Thomas, Pilar Aguar, Hajime Kawasaki, Jeff Morris, Junko Nakanishi, and Nora Savage

Research Strategies for Safety Evaluation of Nanomaterials, Part VIII: International Efforts to Develop Risk-Based Safety Evaluations for Nanomaterials
ToxSci Advance Access published on May 9, 2006
Toxicol. Sci. 2006 92: 23-32; doi:10.1093/toxsci/kfj211 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Guoli Dai, Lin He, Nathan Chou, and Yu-Jui Yvonne Wan

Acetaminophen Metabolism Does Not Contribute to Gender Difference in Its Hepatotoxicity in Mouse
ToxSci Advance Access published on April 11, 2006
Toxicol. Sci. 2006 92: 33-41; doi:10.1093/toxsci/kfj192 [Abstract] [Full Text] [PDF] [Request Permissions]  

Irvin R. Schultz and Robert E. Shangraw

Effect of Short-Term Drinking Water Exposure to Dichloroacetate on its Pharmacokinetics and Oral Bioavailability in Human Volunteers: A Stable Isotope Study
ToxSci Advance Access published on April 12, 2006
Toxicol. Sci. 2006 92: 42-50; doi:10.1093/toxsci/kfj193 [Abstract] [Full Text] [PDF] [Request Permissions]  

Kun Wang, Alphonse J. Mendy, Guoli Dai, Huai-Rong Luo, Lin He, and Yu-Jui Yvonne Wan

Retinoids Activate the RXR/SXR-Mediated Pathway and Induce the Endogenous CYP3A4 Activity in Huh7 Human Hepatoma Cells
ToxSci Advance Access published on April 21, 2006
Toxicol. Sci. 2006 92: 51-60; doi:10.1093/toxsci/kfj207 [Abstract] [Full Text] [PDF] [Request Permissions]  

Douglas O. Johns, William E. Daniell, Danny D. Shen, David A. Kalman, Russell L. Dills, and Michael S. Morgan

Ethanol-Induced Increase in the Metabolic Clearance of 1,1,1-Trichloroethane in Human Volunteers
ToxSci Advance Access published on April 25, 2006
Toxicol. Sci. 2006 92: 61-70; doi:10.1093/toxsci/kfj210 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Yun Wang, Kai Woo Lee, Franky L. Chan, Shiuan Chen, and Lai K. Leung

The Red Wine Polyphenol Resveratrol Displays Bilevel Inhibition on Aromatase in Breast Cancer Cells
ToxSci Advance Access published on April 11, 2006
Toxicol. Sci. 2006 92: 71-77; doi:10.1093/toxsci/kfj190 [Abstract] [Full Text] [PDF] [Request Permissions]  

Eva Rached, Erika Pfeiffer, Wolfgang Dekant, and Angela Mally

Ochratoxin A: Apoptosis and Aberrant Exit from Mitosis due to Perturbation of Microtubule Dynamics?
ToxSci Advance Access published on April 26, 2006
Toxicol. Sci. 2006 92: 78-86; doi:10.1093/toxsci/kfj213 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Yumiko Kudo, Kiyoshi Yamauchi, Hitoshi Fukazawa, and Yoshiyasu Terao

In Vitro and In Vivo Analysis of the Thyroid System–Disrupting Activities of Brominated Phenolic and Phenol Compounds in Xenopus laevis
ToxSci Advance Access published on April 20, 2006
Toxicol. Sci. 2006 92: 87-95; doi:10.1093/toxsci/kfj204 [Abstract] [Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY:

Eliza Grlickova-Duzevik, Sandra S. Wise, Ray C. Munroe, W. Douglas Thompson, and John Pierce Wise, Sr

XRCC1 Protects against Particulate Chromate–Induced Chromosome Damage and Cytotoxicity in Chinese Hamster Ovary Cells
ToxSci Advance Access published on April 5, 2006
Toxicol. Sci. 2006 92: 96-102; doi:10.1093/toxsci/kfj183 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXIOCOLOGY:

Sarah J. Blossom and Kathleen M. Gilbert

Exposure to a Metabolite of the Environmental Toxicant, Trichloroethylene, Attenuates CD4⁺ T Cell Activation-Induced Cell Death by Metalloproteinase–Dependent FasL Shedding
ToxSci Advance Access published on April 26, 2006
Toxicol. Sci. 2006 92: 103-114; doi:10.1093/toxsci/kfj212 [Abstract] [Full Text] [PDF] [Request Permissions]  

Marcia E. Klein-Patel, Gill Diamond, Michele Boniotto, Sherif Saad, and Lisa K. Ryan

Inhibition of ß-Defensin Gene Expression in Airway Epithelial Cells by Low Doses of Residual Oil Fly Ash is Mediated by Vanadium
ToxSci Advance Access published on April 26, 2006
Toxicol. Sci. 2006 92: 115-125; doi:10.1093/toxsci/kfj214 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY:

Robert F. Phalen, Michael J. Oldham, and Andre E. Nel

Tracheobronchial Particle Dose Considerations for In Vitro Toxicology Studies
ToxSci Advance Access published on April 5, 2006
Toxicol. Sci. 2006 92: 126-132; doi:10.1093/toxsci/kfj182 [Abstract] [Full Text] [PDF] [Request Permissions]  

A. K. Peters, S. Nijmeijer, K. Gradin, M. Backlund, Å. Bergman, L. Poellinger, M. S. Denison, and M. Van den Berg

Interactions of Polybrominated Diphenyl Ethers with the Aryl Hydrocarbon Receptor Pathway
ToxSci Advance Access published on April 6, 2006
Toxicol. Sci. 2006 92: 133-142; doi:10.1093/toxsci/kfj186 [Abstract] [Full Text] [PDF] [Request Permissions]  

Grace E. Kissling, Naomi J. Bernheim, William E. Hawkins, Marilyn J. Wolfe, Micheal P. Jokinen, Cynthia S. Smith, Ronald A. Herbert, and Gary A. Boorman

The Utility of the Guppy (Poecilia reticulata) and Medaka (Oryzias latipes) in Evaluation of Chemicals for Carcinogenicity
ToxSci Advance Access published on March 31, 2006
Toxicol. Sci. 2006 92: 143-156; doi:10.1093/toxsci/kfj181 [Abstract] [Full Text] [PDF] [Request Permissions]  

Timo Hamers, Jorke H. Kamstra, Edwin Sonneveld, Albertinka J. Murk, Monique H. A. Kester, Patrik L. Andersson, Juliette Legler, and Abraham Brouwer

In Vitro Profiling of the Endocrine-Disrupting Potency of Brominated Flame Retardants
ToxSci Advance Access published on April 6, 2006
Toxicol. Sci. 2006 92: 157-173; doi:10.1093/toxsci/kfj187 [Abstract] [Full Text] [PDF] [Request Permissions]  

Christie M. Sayes, Rajeev Wahi, Preetha A. Kurian, Yunping Liu, Jennifer L. West, Kevin D. Ausman, David B. Warheit, and Vicki L. Colvin

Correlating Nanoscale Titania Structure with Toxicity: A Cytotoxicity and Inflammatory Response Study with Human Dermal Fibroblasts and Human Lung Epithelial Cells
ToxSci Advance Access published on April 12, 2006
Toxicol. Sci. 2006 92: 174-185; doi:10.1093/toxsci/kfj197 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

James Hynes, Lisa D. Marroquin, Vladimir I. Ogurtsov, Katerina N. Christiansen, Gregory J. Stevens, Dmitri B. Papkovsky, and Yvonne Will

Investigation of Drug-Induced Mitochondrial Toxicity Using Fluorescence-Based Oxygen-Sensitive Probes
ToxSci Advance Access published on April 25, 2006
Toxicol. Sci. 2006 92: 186-200; doi:10.1093/toxsci/kfj208 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

David C. Dorman, Melanie F. Struve, Marianne W. Marshall, Carl U. Parkinson, R. Arden James, and Brian A. Wong

Tissue Manganese Concentrations in Young Male Rhesus Monkeys following Subchronic Manganese Sulfate Inhalation
ToxSci Advance Access published on April 19, 2006
Toxicol. Sci. 2006 92: 201-210; doi:10.1093/toxsci/kfj206 [Abstract] [Full Text] [PDF] [Request Permissions]  

Henrik Viberg, Niclas Johansson, Anders Fredriksson, Johan Eriksson, Göran Marsh, and Per Eriksson

Neonatal Exposure to Higher Brominated Diphenyl Ethers, Hepta-, Octa-, or Nonabromodiphenyl Ether, Impairs Spontaneous Behavior and Learning and Memory Functions of Adult Mice
ToxSci Advance Access published on April 12, 2006
Toxicol. Sci. 2006 92: 211-218; doi:10.1093/toxsci/kfj196 [Abstract] [Full Text] [PDF] [Request Permissions]  

David C. Dorman, Melanie F. Struve, Brian A. Wong, Janice A. Dye, and Ian D. Robertson

Correlation of Brain Magnetic Resonance Imaging Changes with Pallidal Manganese Concentrations in Rhesus Monkeys Following Subchronic Manganese Inhalation
ToxSci Advance Access published on April 25, 2006
Toxicol. Sci. 2006 92: 219-227; doi:10.1093/toxsci/kfj209 [Abstract] [Full Text] [PDF] [Request Permissions]  

John B. Morris and Lynn H. Pottenger

Nasal NPSH Depletion and Propylene Oxide Uptake in the Upper Respiratory Tract of the Mouse
ToxSci Advance Access published on April 11, 2006
Toxicol. Sci. 2006 92: 228-234; doi:10.1093/toxsci/kfj195 [Abstract] [Full Text] [PDF] [Request Permissions]  

Virginia C. Moser, Jane Ellen Simmons, and Chris Gennings

Neurotoxicological Interactions of a Five-Pesticide Mixture in Preweanling Rats
ToxSci Advance Access published on April 11, 2006
Toxicol. Sci. 2006 92: 235-245; doi:10.1093/toxsci/kfj189 [Abstract] [Full Text] [PDF] [Request Permissions]  

Michelle L. Herdman, Aileen Marcelo, Ying Huang, Richard M. Niles, Sanjit Dhar, and Kinsley Kelley Kiningham

Thimerosal Induces Apoptosis in a Neuroblastoma Model via the cJun N-Terminal Kinase Pathway
ToxSci Advance Access published on April 19, 2006
Toxicol. Sci. 2006 92: 246-253; doi:10.1093/toxsci/kfj205 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Eric A. Andreasen, Lijoy K. Mathew, and Robert L. Tanguay

Regenerative Growth Is Impacted by TCDD: Gene Expression Analysis Reveals Extracellular Matrix Modulation
ToxSci Advance Access published on January 27, 2006
Toxicol. Sci. 2006 92: 254-269; doi:10.1093/toxsci/kfj118 [Abstract] [Full Text] [PDF] [Request Permissions]  

Carla M. Stehr, Tiffany L. Linbo, John P. Incardona, and Nathaniel L. Scholz

The Developmental Neurotoxicity of Fipronil: Notochord Degeneration and Locomotor Defects in Zebrafish Embryos and Larvae
ToxSci Advance Access published on April 12, 2006
Toxicol. Sci. 2006 92: 270-278; doi:10.1093/toxsci/kfj185 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Eija Peltonen, Pirjo-Liisa Lukinmaa, Carin Sahlberg, Anna-Maija Partanen, Anu Kiukkonen, and Satu Alaluusua

7,12-Dimethylbenz[a]anthracene Interferes with the Development of Cultured Mouse Mandibular Molars
ToxSci Advance Access published on April 13, 2006
Toxicol. Sci. 2006 92: 279-285; doi:10.1093/toxsci/kfj199 [Abstract] [Full Text] [PDF] [Request Permissions]  

Jennifer A. Jamieson, Carla G. Taylor, and Hope A. Weiler

Marginal Zinc Deficiency Exacerbates Bone Lead Accumulation and High Dietary Zinc Attenuates Lead Accumulation at the Expense of Bone Density in Growing Rats
ToxSci Advance Access published on April 19, 2006
Toxicol. Sci. 2006 92: 286-294; doi:10.1093/toxsci/kfj201 [Abstract] [Full Text] [PDF] [Request Permissions]  

Rochelle W. Tyl, Christina B. Myers, Melissa C. Marr, Nora P. Castillo, John C. Seely, Carol S. Sloan, Michael M. Veselica, Ronald L. Joiner, John P. Van Miller, and Glenn S. Simon

Three-Generation Evaluation of Dietary para-Nonylphenol in CD (Sprague-Dawley) Rats
ToxSci Advance Access published on April 19, 2006
Toxicol. Sci. 2006 92: 295-310; doi:10.1093/toxsci/kfj203 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Sung Yong Eum, Geun Bae Rha, Bernhard Hennig, and Michal Toborek

c-Src Is the Primary Signaling Mediator of Polychlorinated Biphenyl–Induced Interleukin-8 Expression in a Human Microvascular Endothelial Cell Line
ToxSci Advance Access published on April 11, 2006
Toxicol. Sci. 2006 92: 311-320; doi:10.1093/toxsci/kfj194 [Abstract] [Full Text] [PDF] [Request Permissions]  

Aimen K. Farraj, Jack R. Harkema, and Norbert E. Kaminski

Topical Application versus Intranasal Instillation: A Qualitative Comparison of the Effect of the Route of Sensitization on Trimellitic Anhydride–Induced Allergic Rhinitis in A/J Mice
ToxSci Advance Access published on April 11, 2006
Toxicol. Sci. 2006 92: 321-328; doi:10.1093/toxsci/kfj191 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

RISK ASSESSMENT:

Daniel L. Hunt and Chin-Shang Li

A Regression Spline Model for Developmental Toxicity Data
ToxSci Advance Access published on April 19, 2006
Toxicol. Sci. 2006 92: 329-334; doi:10.1093/toxsci/kfj202 [Abstract] [Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Ronald T. Riley and Kenneth A. Voss

Differential Sensitivity of Rat Kidney and Liver to Fumonisin Toxicity: Organ-Specific Differences in Toxin Accumulation and Sphingoid Base Metabolism
ToxSci Advance Access published on April 12, 2006
Toxicol. Sci. 2006 92: 335-345; doi:10.1093/toxsci/kfj198 [Abstract] [Full Text] [PDF] [Request Permissions]  

LETTERS TO THE EDITOR:

John F. Fox

TO THE EDITOR
ToxSci Advance Access published on April 18, 2006
Toxicol. Sci. 2006 92: 346; doi:10.1093/toxsci/kfj200 [Extract] [Full Text] [PDF] [Request Permissions]  

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