Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Michael L. Cunningham

Putting the Fun Into Functional Toxicogenomics
Toxicol. Sci. 2006 92: 347-348; doi:10.1093/toxsci/kfl027 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Rhonda M. Brand, Jessica L. Jendrzejewski, Eric M. Henery, and Anna R. Charron

A Single Oral Dose of Ethanol Can Alter Transdermal Absorption of Topically Applied Chemicals in Rats
ToxSci Advance Access published on May 5, 2006
Toxicol. Sci. 2006 92: 349-355; doi:10.1093/toxsci/kfl010 [Abstract] [Full Text] [PDF] [Request Permissions]  

Richard A. Graham, Bryan Goodwin, Raymond V. Merrihew, Wojciech L. Krol, and Edward L. LeCluyse

Cloning, Tissue Expression, and Regulation of Beagle Dog CYP4A Genes
ToxSci Advance Access published on May 4, 2006
Toxicol. Sci. 2006 92: 356-367; doi:10.1093/toxsci/kfl009 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Shen Xiao, Steven P. Anderson, Cynthia Swanson, Rainer Bahnemann, Kenneth A. Voss, Anja J. Stauber, and J. Christopher Corton

Activation of Peroxisome Proliferator–Activated Receptor Alpha Enhances Apoptosis in the Mouse Liver
ToxSci Advance Access published on May 9, 2006
Toxicol. Sci. 2006 92: 368-377; doi:10.1093/toxsci/kfl002 [Abstract] [Full Text] [PDF] [Request Permissions]  

Stacy M. Corthals, Lisa M. Kamendulis, and James E. Klaunig

Mechanisms of 2-Butoxyethanol–Induced Hemangiosarcomas
ToxSci Advance Access published on May 4, 2006
Toxicol. Sci. 2006 92: 378-386; doi:10.1093/toxsci/kfl007 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Nick A. Lewis, Tim D. Williams, and James K. Chipman

Functional Analysis of a Metal Response Element in the Regulatory Region of Flounder Cytochrome P450 1A and Implications for Environmental Monitoring of Pollutants
ToxSci Advance Access published on May 19, 2006
Toxicol. Sci. 2006 92: 387-393; doi:10.1093/toxsci/kfl023 [Abstract] [Full Text] [PDF] [Request Permissions]  

Akira Kubota, Hisato Iwata, Heather M. H. Goldstone, Eun-Young Kim, John J. Stegeman, and Shinsuke Tanabe

Cytochrome P450 1A4 and 1A5 in Common Cormorant (Phalacrocorax carbo): Evolutionary Relationships and Functional Implications Associated with Dioxin and Related Compounds
ToxSci Advance Access published on May 5, 2006
Toxicol. Sci. 2006 92: 394-408; doi:10.1093/toxsci/kfl001 [Abstract] [Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY:

Eliza Grlickova-Duzevik, Sandra S. Wise, Ray C. Munroe, W. Douglas Thompson, and John Pierce Wise, Sr

XRCC1 Protects against Particulate Chromate–Induced Chromosome Damage and Cytotoxicity in Chinese Hamster Ovary Cells
ToxSci Advance Access published on May 19, 2006
Toxicol. Sci. 2006 92: 409-415; doi:10.1093/toxsci/kfl021 [Abstract] [Full Text] [PDF] [Request Permissions]  

Parri Wentzel and Ulf J. Eriksson

Ethanol-Induced Fetal Dysmorphogenesis in the Mouse Is Diminished by High Antioxidative Capacity of the Mother
ToxSci Advance Access published on May 26, 2006
Toxicol. Sci. 2006 92: 416-422; doi:10.1093/toxsci/kfl024 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXIOCOLOGY:

Stéphane Pillet, Michele D'Elia, Jacques Bernier, Jean-Marie Bouquegneau, Michel Fournier, and Daniel G. Cyr

Immunomodulatory Effects of Estradiol and Cadmium in Adult Female Rats
ToxSci Advance Access published on May 4, 2006
Toxicol. Sci. 2006 92: 423-432; doi:10.1093/toxsci/kfl005 [Abstract] [Full Text] [PDF] [Request Permissions]  

Jennifer J. Schlezinger, Jessica K. Emberley, and David H. Sherr

Activation of Multiple Mitogen-Activated Protein Kinases in Pro/Pre–B Cells by GW7845, a Peroxisome Proliferator–Activated Receptor Agonist, and Their Contribution to GW7845-Induced Apoptosis
ToxSci Advance Access published on May 3, 2006
Toxicol. Sci. 2006 92: 433-444; doi:10.1093/toxsci/kfl003 [Abstract] [Full Text] [PDF] [Request Permissions]  

James Pestka and Hui-Ren Zhou

Toll-Like Receptor Priming Sensitizes Macrophages to Proinflammatory Cytokine Gene Induction by Deoxynivalenol and Other Toxicants
ToxSci Advance Access published on May 9, 2006
Toxicol. Sci. 2006 92: 445-455; doi:10.1093/toxsci/kfl012 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY:

Saber M. Hussain, Amanda K. Javorina, Amanda M. Schrand, Helen M. Duhart, Syed F. Ali, and John J. Schlager

The Interaction of Manganese Nanoparticles with PC-12 Cells Induces Dopamine Depletion
ToxSci Advance Access published on May 19, 2006
Toxicol. Sci. 2006 92: 456-463; doi:10.1093/toxsci/kfl020 [Abstract] [Full Text] [PDF] [Request Permissions]  

Muhammad Nawaz, Claudia Manzl, Veronika Lacher, and Gerhard Krumschnabel

Copper-Induced Stimulation of Extracellular Signal-Regulated Kinase in Trout Hepatocytes: The Role of Reactive Oxygen Species, Ca²⁺, and Cell Energetics and the Impact of Extracellular Signal-Regulated Kinase Signaling on Apoptosis and Necrosis
ToxSci Advance Access published on May 3, 2006
Toxicol. Sci. 2006 92: 464-475; doi:10.1093/toxsci/kfl006 [Abstract] [Full Text] [PDF] [Request Permissions]  

John P. Vanden Heuvel, Jerry T. Thompson, Steven R. Frame, and Peter J. Gillies

Differential Activation of Nuclear Receptors by Perfluorinated Fatty Acid Analogs and Natural Fatty Acids: A Comparison of Human, Mouse, and Rat Peroxisome Proliferator-Activated Receptor-, -ß, and -, Liver X Receptor-ß, and Retinoid X Receptor-
ToxSci Advance Access published on May 26, 2006
Toxicol. Sci. 2006 92: 476-489; doi:10.1093/toxsci/kfl014 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

NEUROTOXICOLOGY:

W. Michael Caudle, Jason R. Richardson, Kristin C. Delea, Thomas S. Guillot, Minzheng Wang, Kurt D. Pennell, and Gary W. Miller

Polychlorinated Biphenyl–Induced Reduction of Dopamine Transporter Expression as a Precursor to Parkinson's Disease–Associated Dopamine Toxicity
ToxSci Advance Access published on May 15, 2006
Toxicol. Sci. 2006 92: 490-499; doi:10.1093/toxsci/kfl018 [Abstract] [Full Text] [PDF] [Request Permissions]  

Angela M. Betancourt, Shane C. Burgess, and Russell L. Carr

Effect of Developmental Exposure to Chlorpyrifos on the Expression of Neurotrophin Growth Factors and Cell-Specific Markers in Neonatal Rat Brain
ToxSci Advance Access published on May 4, 2006
Toxicol. Sci. 2006 92: 500-506; doi:10.1093/toxsci/kfl004 [Abstract] [Full Text] [PDF] [Request Permissions]  

Mireia Niso-Santano, José M. Morán, Lourdes García-Rubio, Ana Gómez-Martín, Rosa A. González-Polo, Germán Soler, and José M. Fuentes

Low Concentrations of Paraquat Induces Early Activation of Extracellular Signal-Regulated Kinase 1/2, Protein Kinase B, and c-Jun N-terminal Kinase 1/2 Pathways: Role of c-Jun N-Terminal Kinase in Paraquat-Induced Cell Death
ToxSci Advance Access published on May 9, 2006
Toxicol. Sci. 2006 92: 507-515; doi:10.1093/toxsci/kfl013 [Abstract] [Full Text] [PDF] [Request Permissions]  

Stephanie J. Garcia, Kristin Gellein, Tore Syversen, and Michael Aschner

A Manganese-Enhanced Diet Alters Brain Metals and Transporters in the Developing Rat
ToxSci Advance Access published on May 16, 2006
Toxicol. Sci. 2006 92: 516-525; doi:10.1093/toxsci/kfl017 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Sonya M. Billiard, Alicia R. Timme-Laragy, Deena M. Wassenberg, Crystal Cockman, and Richard T. Di Giulio

The Role of the Aryl Hydrocarbon Receptor Pathway in Mediating Synergistic Developmental Toxicity of Polycyclic Aromatic Hydrocarbons to Zebrafish
ToxSci Advance Access published on May 9, 2006
Toxicol. Sci. 2006 92: 526-536; doi:10.1093/toxsci/kfl011 [Abstract] [Full Text] [PDF] [Request Permissions]  

Angelique Vetillard and Thierry Bailhache

Effects of 4-n-Nonylphenol and Tamoxifen on Salmon Gonadotropin-Releasing Hormone, Estrogen Receptor, and Vitellogenin Gene Expression in Juvenile Rainbow Trout
ToxSci Advance Access published on May 16, 2006
Toxicol. Sci. 2006 92: 537-544; doi:10.1093/toxsci/kfl015 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Thomas H. March, Julie A. Wilder, Dolores C. Esparza, Patsy Y. Cossey, Lee F. Blair, Lois K. Herrera, Jacob D. McDonald, Matthew J. Campen, Joe L. Mauderly, and JeanClare Seagrave

Modulators of Cigarette Smoke–Induced Pulmonary Emphysema in A/J Mice
ToxSci Advance Access published on May 12, 2006
Toxicol. Sci. 2006 92: 545-559; doi:10.1093/toxsci/kfl016 [Abstract] [Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Xiaozhong Yu, William C. Griffith, Kristina Hanspers, James F. Dillman, III, Hansel Ong, Melinda A. Vredevoogd, and Elaine M. Faustman

A System-Based Approach to Interpret Dose- and Time-Dependent Microarray Data: Quantitative Integration of Gene Ontology Analysis for Risk Assessment
ToxSci Advance Access published on April 6, 2006
Toxicol. Sci. 2006 92: 560-577; doi:10.1093/toxsci/kfj184 [Abstract] [Full Text] [PDF] [Request Permissions]  

Angus T. De Souza, Paul D. Cornwell, Xudong Dai, Michelle J. Caguyong, and Roger G. Ulrich

Agonists of the Peroxisome Proliferator–Activated Receptor Alpha Induce a Fiber-Type–Selective Transcriptional Response in Rat Skeletal Muscle
ToxSci Advance Access published on May 17, 2006
Toxicol. Sci. 2006 92: 578-586; doi:10.1093/toxsci/kfl019 [Abstract] [Full Text] [PDF] [Request Permissions]  

Carolyn J. Mattingly, Michael C. Rosenstein, Allan Peter Davis, Glenn T. Colby, John N. Forrest, Jr, and James L. Boyer

The Comparative Toxicogenomics Database: A Cross-Species Resource for Building Chemical-Gene Interaction Networks
ToxSci Advance Access published on May 4, 2006
Toxicol. Sci. 2006 92: 587-595; doi:10.1093/toxsci/kfl008 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

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