Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

John M. Rogers

Casting a Broad Network: Fishing for Mechanisms of Retinoid Teratogenicity
Toxicol. Sci. 2006 94: 1-2; doi:10.1093/toxsci/kfl104 [Extract] [Full Text] [PDF] [Request Permissions]  

REVIEW:

J. Thomas Sanderson

The Steroid Hormone Biosynthesis Pathway as a Target for Endocrine-Disrupting Chemicals
ToxSci Advance Access published on June 28, 2006
Toxicol. Sci. 2006 94: 3-21; doi:10.1093/toxsci/kfl051 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

FORUM:

Robert W. Luebke, Michael P. Holsapple, Gregory S. Ladics, Michael I. Luster, MaryJane Selgrade, Ralph J. Smialowicz, Michael R. Woolhiser, and Dori R. Germolec

Immunotoxicogenomics: The Potential of Genomics Technology in the Immunotoxicity Risk Assessment Process
ToxSci Advance Access published on August 1, 2006
Toxicol. Sci. 2006 94: 22-27; doi:10.1093/toxsci/kfl074 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Daniele F. Staskal, Heldur Hakk, Daniel Bauer, Janet J. Diliberto, and Linda S. Birnbaum

Toxicokinetics of Polybrominated Diphenyl Ether Congeners 47, 99, 100, and 153 in Mice
ToxSci Advance Access published on August 25, 2006
Toxicol. Sci. 2006 94: 28-37; doi:10.1093/toxsci/kfl091 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Shou-Lin Wang, Xiao-Yang He, Jian Shen, Jia-Sheng Wang, and Jun-Yan Hong

The Missense Genetic Polymorphisms of Human CYP2A13: Functional Significance in Carcinogen Activation and Identification of A Null Allelic Variant
ToxSci Advance Access published on August 17, 2006
Toxicol. Sci. 2006 94: 38-45; doi:10.1093/toxsci/kfl081 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Susan C. Laws, S Yavanhxay, Ralph L. Cooper, and J. Charles Eldridge

Nature of the Binding Interaction for 50 Structurally Diverse Chemicals with Rat Estrogen Receptors
ToxSci Advance Access published on August 29, 2006
Toxicol. Sci. 2006 94: 46-56; doi:10.1093/toxsci/kfl092 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Hiroki Sakai, Hisato Iwata, Eun-Young Kim, Oyuna Tsydenova, Nobuyuki Miyazaki, Evgeny A. Petrov, Valeriy B. Batoev, and Shinsuke Tanabe

Constitutive Androstane Receptor (CAR) as a Potential Sensing Biomarker of Persistent Organic Pollutants (POPs) in Aquatic Mammal: Molecular Characterization, Expression Level, and Ligand Profiling in Baikal Seal (Pusa sibirica)
ToxSci Advance Access published on August 23, 2006
Toxicol. Sci. 2006 94: 57-70; doi:10.1093/toxsci/kfl088 [Abstract] [Full Text] [PDF] [Request Permissions]  

Henri Wintz, Leslie J. Yoo, Alex Loguinov, Ying-Ying Wu, Jeffrey A. Steevens, Ricky D. Holland, Richard D. Beger, Edward J. Perkins, Owen Hughes, and Chris D. Vulpe

Gene Expression Profiles in Fathead Minnow Exposed to 2,4-DNT: Correlation with Toxicity in Mammals
ToxSci Advance Access published on August 17, 2006
Toxicol. Sci. 2006 94: 71-82; doi:10.1093/toxsci/kfl080 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

GENETIC TOXICOLOGY:

Stephen D. Dertinger, Michelle E. Bishop, James P. McNamee, Makoto Hayashi, Takayoshi Suzuki, Norihide Asano, Madoka Nakajima, Junichiro Saito, Martha Moore, Dorothea K. Torous, and James T. MacGregor

Flow Cytometric Analysis of Micronuclei in Peripheral Blood Reticulocytes: I. Intra- and Interlaboratory Comparison with Microscopic Scoring
ToxSci Advance Access published on August 3, 2006
Toxicol. Sci. 2006 94: 83-91; doi:10.1093/toxsci/kfl075 [Abstract] [Full Text] [PDF] [Request Permissions]  

James T. MacGregor, Michelle E. Bishop, James P. McNamee, Makoto Hayashi, Norhide Asano, Akihiro Wakata, Madoka Nakajima, Junichiro Saito, Anane Aidoo, Martha M. Moore, and Stephen D. Dertinger

Flow Cytometric Analysis of Micronuclei in Peripheral Blood Reticulocytes: II. An Efficient Method of Monitoring Chromosomal Damage in the Rat
ToxSci Advance Access published on August 3, 2006
Toxicol. Sci. 2006 94: 92-107; doi:10.1093/toxsci/kfl076 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXIOCOLOGY:

MaryJaneK Selgrade, Elizabeth H. Boykin, Najwa Haykal-Coates, Michael R. Woolhiser, Connie Wiescinski, Debora L. Andrews, Aimen K. Farraj, Donald L. Doerfler, and Stephen H. Gavett

Inconsistencies between Cytokine Profiles, Antibody Responses, and Respiratory Hyperresponsiveness following Dermal Exposure to Isocyanates
ToxSci Advance Access published on August 28, 2006
Toxicol. Sci. 2006 94: 108-117; doi:10.1093/toxsci/kfl094 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY:

Shanmugam Muruganandan and Alastair E. Cribb

Calpain-Induced Endoplasmic Reticulum Stress and Cell Death following Cytotoxic Damage to Renal Cells
ToxSci Advance Access published on August 18, 2006
Toxicol. Sci. 2006 94: 118-128; doi:10.1093/toxsci/kfl084 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Richard K. Monroe and Stanley W. Halvorsen

Mercury Abolishes Neurotrophic Factor–Stimulated Jak-STAT Signaling in Nerve Cells by Oxidative Stress
ToxSci Advance Access published on August 8, 2006
Toxicol. Sci. 2006 94: 129-138; doi:10.1093/toxsci/kfl073 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Sarah E. Ali-Khan and Barbara F. Hales

Novel Retinoid Targets in the Mouse Limb during Organogenesis
ToxSci Advance Access published on June 13, 2006
Toxicol. Sci. 2006 94: 139-152; doi:10.1093/toxsci/kfl037 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Victoria J. Drake, Stacy L. Koprowski, Norman Hu, Susan M. Smith, and John Lough

Cardiogenic Effects of Trichloroethylene and Trichloroacetic Acid Following Exposure during Heart Specification of Avian Development
ToxSci Advance Access published on August 17, 2006
Toxicol. Sci. 2006 94: 153-162; doi:10.1093/toxsci/kfl083 [Abstract] [Full Text] [PDF] [Request Permissions]  

Sharon SH. Choi, Margaret A. Miller, and Patricia A. Harper

In Utero Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Amphiregulin Gene Expression in the Developing Mouse Ureter
ToxSci Advance Access published on August 23, 2006
Toxicol. Sci. 2006 94: 163-174; doi:10.1093/toxsci/kfl090 [Abstract] [Full Text] [PDF] [Request Permissions]  

Dagmara S. Antkiewicz, Richard E. Peterson, and Warren Heideman

Blocking Expression of AHR2 and ARNT1 in Zebrafish Larvae Protects Against Cardiac Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin
ToxSci Advance Access published on August 25, 2006
Toxicol. Sci. 2006 94: 175-182; doi:10.1093/toxsci/kfl093 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Aimen K. Farraj, Najwa Haykal-Coates, Allen D. Ledbetter, Paul A. Evansky, and Stephen H. Gavett

Neurotrophin Mediation of Allergic Airways Responses to Inhaled Diesel Particles in Mice
ToxSci Advance Access published on August 23, 2006
Toxicol. Sci. 2006 94: 183-192; doi:10.1093/toxsci/kfl089 [Abstract] [Full Text] [PDF] [Request Permissions]  

Urmila P. Kodavanti, Mette C. Schladweiler, Allen D. Ledbetter, Roselia Villalobos Ortuno, Marie Suffia, Paul Evansky, Judy H. Richards, Richard H. Jaskot, Ronald Thomas, Edward Karoly, Yuh-Chin T. Huang, Daniel L. Costa, Peter S. Gilmour, and Kent E. Pinkerton

The Spontaneously Hypertensive Rat: An Experimental Model of Sulfur Dioxide–Induced Airways Disease
ToxSci Advance Access published on August 23, 2006
Toxicol. Sci. 2006 94: 193-205; doi:10.1093/toxsci/kfl087 [Abstract] [Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Hu-Quan Yin, Mingoo Kim, Ju-Han Kim, Gu Kong, Mi-Ock Lee, Kyung-Sun Kang, Byung-IL Yoon, Hyung-Lae Kim, and Byung-Hoon Lee

Hepatic Gene Expression Profiling and Lipid Homeostasis in Mice Exposed to Steatogenic Drug, Tetracycline
ToxSci Advance Access published on August 17, 2006
Toxicol. Sci. 2006 94: 206-216; doi:10.1093/toxsci/kfl078 [Abstract] [Full Text] [PDF] [Request Permissions]  

Mary Lynn Bajt, Cathleen Cover, John J. Lemasters, and Hartmut Jaeschke

Nuclear Translocation of Endonuclease G and Apoptosis-Inducing Factor during Acetaminophen-Induced Liver Cell Injury
ToxSci Advance Access published on August 8, 2006
Toxicol. Sci. 2006 94: 217-225; doi:10.1093/toxsci/kfl077 [Abstract] [Full Text] [PDF] [Request Permissions]  

Shawn D. Seidel, Shao-Ching Hung, H Lynn Kan, and B Bhaskar Gollapudi

Background Gene Expression in Rat Kidney: Influence of Strain, Gender, and Diet
ToxSci Advance Access published on August 17, 2006
Toxicol. Sci. 2006 94: 226-233; doi:10.1093/toxsci/kfl082 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

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