Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Abby D. Benninghoff

Toxicoproteomics—The Next Step in the Evolution of Environmental Biomarkers?
Toxicol. Sci. 2007 95: 1-4; doi:10.1093/toxsci/kfl157 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

David J. Dix, Keith A. Houck, Matthew T. Martin, Ann M. Richard, R. Woodrow Setzer, and Robert J. Kavlock

The ToxCast Program for Prioritizing Toxicity Testing of Environmental Chemicals
ToxSci Advance Access published on September 8, 2006
Toxicol. Sci. 2007 95: 5-12; doi:10.1093/toxsci/kfl103 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Jian Yang and Bingfang Yan

Photochemotherapeutic Agent 8-Methoxypsoralen Induces Cytochrome P450 3A4 and Carboxylesterase HCE2: Evidence on an Involvement of the Pregnane X Receptor
ToxSci Advance Access published on September 26, 2006
Toxicol. Sci. 2007 95: 13-22; doi:10.1093/toxsci/kfl120 [Abstract] [Full Text] [PDF] [Request Permissions]  

Weihsueh A. Chiu, Sandrine Micallef, Aart C. Monster, and Frédéric Y. Bois

Toxicokinetics of Inhaled Trichloroethylene and Tetrachloroethylene in Humans at 1 ppm: Empirical Results and Comparisons with Previous Studies
ToxSci Advance Access published on October 10, 2006
Toxicol. Sci. 2007 95: 23-36; doi:10.1093/toxsci/kfl129 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

György A. Csanády and Johannes G. Filser

A Physiological Toxicokinetic Model for Inhaled Propylene Oxide in Rat and Human with Special Emphasis on the Nose
ToxSci Advance Access published on October 24, 2006
Toxicol. Sci. 2007 95: 37-62; doi:10.1093/toxsci/kfl140 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

CARCINOGENICITY:

Lauren A. Courter, Tamara Musafia-Jeknic, Kay Fischer, Robert Bildfell, Jack Giovanini, Cliff Pereira, and William M. Baird

Urban Dust Particulate Matter Alters PAH-Induced Carcinogenesis by Inhibition of CYP1A1 and CYP1B1
ToxSci Advance Access published on October 23, 2006
Toxicol. Sci. 2007 95: 63-73; doi:10.1093/toxsci/kfl137 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Calvin C. Walker, Kimberly A. Salinas, Peggy S. Harris, Sherry S. Wilkinson, James D. Watts, and Michael J. Hemmer

A Proteomic (SELDI-TOF-MS) Approach to Estrogen Agonist Screening
ToxSci Advance Access published on August 17, 2006
Toxicol. Sci. 2007 95: 74-81; doi:10.1093/toxsci/kfl079 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Shih-Chieh Chen, Ming-Hsien Tsai, Hsiu-Jen Wang, Hsin-Su Yu, and Louis W. Chang

Involvement of Substance P and Neurogenic Inflammation in Arsenic-Induced Early Vascular Dysfunction
ToxSci Advance Access published on October 20, 2006
Toxicol. Sci. 2007 95: 82-88; doi:10.1093/toxsci/kfl136 [Abstract] [Full Text] [PDF] [Request Permissions]  

Sachin Bhusari, Zhilin Liu, Leonard B. Hearne, Donald E. Spiers, William R. Lamberson, and Eric Antoniou

Expression Profiling of Heat Stress Effects on Mice Fed Ergot Alkaloids
ToxSci Advance Access published on November 8, 2006
Toxicol. Sci. 2007 95: 89-97; doi:10.1093/toxsci/kfl142 [Abstract] [Full Text] [PDF] [Request Permissions]  

Theresa N. Operaña, Nghia Nguyen, Shujuan Chen, Deirdre Beaton, and Robert H. Tukey

Human CYP1A1^GFP Expression in Transgenic Mice Serves as a Biomarker for Environmental Toxicant Exposure
ToxSci Advance Access published on October 25, 2006
Toxicol. Sci. 2007 95: 98-107; doi:10.1093/toxsci/kfl144 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

IN VITRO TOXICOLOGY:

Margy L. Takacs and Barbara D. Abbott

Activation of Mouse and Human Peroxisome Proliferator–Activated Receptors (, ß/, ) by Perfluorooctanoic Acid and Perfluorooctane Sulfonate
ToxSci Advance Access published on October 17, 2006
Toxicol. Sci. 2007 95: 108-117; doi:10.1093/toxsci/kfl135 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

David W. Herr, Jaimie E. Graff, Virginia C. Moser, Kevin M. Crofton, Peter B. Little, Daniel L. Morgan, and Robert C. Sills

Inhalational Exposure to Carbonyl Sulfide Produces Altered Brainstem Auditory and Somatosensory-Evoked Potentials in Fischer 344N Rats
ToxSci Advance Access published on November 1, 2006
Toxicol. Sci. 2007 95: 118-135; doi:10.1093/toxsci/kfl146 [Abstract] [Full Text] [PDF] [Request Permissions]  

Richard M. LoPachin, David S. Barber, Brian C. Geohagen, Terrence Gavin, Deke He, and Soma Das

Structure-Toxicity Analysis of Type-2 Alkenes: In Vitro Neurotoxicity
ToxSci Advance Access published on October 5, 2006
Toxicol. Sci. 2007 95: 136-146; doi:10.1093/toxsci/kfl127 [Abstract] [Full Text] [PDF] [Request Permissions]  

Ahmed A. Kousba, Torka S. Poet, and Charles Timchalk

Age-Related Brain Cholinesterase Inhibition Kinetics following In Vitro Incubation with Chlorpyrifos-Oxon and Diazinon-Oxon
ToxSci Advance Access published on October 3, 2006
Toxicol. Sci. 2007 95: 147-155; doi:10.1093/toxsci/kfl123 [Abstract] [Full Text] [PDF] [Request Permissions]  

Lidia Struzynska, Beata Dabrowska-Bouta, Katarzyna Koza, and Grzegorz Sulkowski

Inflammation-Like Glial Response in Lead-Exposed Immature Rat Brain
ToxSci Advance Access published on October 17, 2006
Toxicol. Sci. 2007 95: 156-162; doi:10.1093/toxsci/kfl134 [Abstract] [Full Text] [PDF] [Request Permissions]  

Sampath Ramachandiran, Jason M. Hansen, Dean P. Jones, Jason R. Richardson, and Gary W. Miller

Divergent Mechanisms of Paraquat, MPP⁺, and Rotenone Toxicity: Oxidation of Thioredoxin and Caspase-3 Activation
ToxSci Advance Access published on October 3, 2006
Toxicol. Sci. 2007 95: 163-171; doi:10.1093/toxsci/kfl125 [Abstract] [Full Text] [PDF] [Request Permissions]  

Motoko Mukai and Shelley A. Tischkau

Effects of Tryptophan Photoproducts in the Circadian Timing System: Searching for a Physiological Role for Aryl Hydrocarbon Receptor
ToxSci Advance Access published on October 4, 2006
Toxicol. Sci. 2007 95: 172-181; doi:10.1093/toxsci/kfl126 [Abstract] [Full Text] [PDF] [Request Permissions]  

Julie Doostzadeh, Ronald W. Davis, Guri N. Giaever, Corey Nislow, and James W. Langston

Chemical Genomic Profiling for Identifying Intracellular Targets of Toxicants Producing Parkinson's Disease
ToxSci Advance Access published on October 16, 2006
Toxicol. Sci. 2007 95: 182-187; doi:10.1093/toxsci/kfl131 [Abstract] [Full Text] [PDF] [Request Permissions]  

Joel G. Anderson, Paula T. Cooney, and Keith M. Erikson

Brain Manganese Accumulation is Inversely Related to -Amino Butyric Acid Uptake in Male and Female Rats
ToxSci Advance Access published on October 10, 2006
Toxicol. Sci. 2007 95: 188-195; doi:10.1093/toxsci/kfl130 [Abstract] [Full Text] [PDF] [Request Permissions]  

Jason R. Richardson, W. Michael Caudle, Thomas S. Guillot, Jodi L. Watson, Eiko Nakamaru-Ogiso, Byoung Boo Seo, Todd B. Sherer, J. Timothy Greenamyre, Takao Yagi, Akemi Matsuno-Yagi, and Gary W. Miller

Obligatory Role for Complex I Inhibition in the Dopaminergic Neurotoxicity of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
ToxSci Advance Access published on October 12, 2006
Toxicol. Sci. 2007 95: 196-204; doi:10.1093/toxsci/kfl133 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Stephanie J. Garcia, Kristin Gellein, Tore Syversen, and Michael Aschner

Iron Deficient and Manganese Supplemented Diets Alter Metals and Transporters in the Developing Rat Brain
ToxSci Advance Access published on October 23, 2006
Toxicol. Sci. 2007 95: 205-214; doi:10.1093/toxsci/kfl139 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Eric A. Andreasen, Lijoy K. Mathew, Christiane V. Löhr, Rachelle Hasson, and Robert L. Tanguay

Aryl Hydrocarbon Receptor Activation Impairs Extracellular Matrix Remodeling during Zebra Fish fin Regeneration
ToxSci Advance Access published on September 26, 2006
Toxicol. Sci. 2007 95: 215-226; doi:10.1093/toxsci/kfl119 [Abstract] [Full Text] [PDF] [Request Permissions]  

Amber K. Goetz, Hongzu Ren, Judith E. Schmid, Chad R. Blystone, Inthirany Thillainadarajah, Deborah S. Best, Harriette P. Nichols, Lillian F. Strader, Douglas C. Wolf, Michael G. Narotsky, John C. Rockett, and David J. Dix

Disruption of Testosterone Homeostasis as a Mode of Action for the Reproductive Toxicity of Triazole Fungicides in the Male Rat
ToxSci Advance Access published on October 3, 2006
Toxicol. Sci. 2007 95: 227-239; doi:10.1093/toxsci/kfl124 [Abstract] [Full Text] [PDF] [Request Permissions]  

Jeffrey C. Bemis, Napoleon F. Alejandro, Daniel A. Nazarenko, Andrew I. Brooks, Raymond B. Baggs, and Thomas A. Gasiewicz

TCDD-Induced Alterations in Gene Expression Profiles of the Developing Mouse Paw Do Not Influence Morphological Differentiation of This Potential Target Tissue
ToxSci Advance Access published on October 11, 2006
Toxicol. Sci. 2007 95: 240-248; doi:10.1093/toxsci/kfl132 [Abstract] [Full Text] [PDF] [Request Permissions]  

LM McClusky, C de Jager, and MS Bornman

Stage-Related Increase in the Proportion of Apoptotic Germ Cells and Altered Frequencies of Stages in the Spermatogenic Cycle Following Gestational, Lactational, and Direct Exposure of Male Rats to p-Nonylphenol
ToxSci Advance Access published on October 25, 2006
Toxicol. Sci. 2007 95: 249-256; doi:10.1093/toxsci/kfl141 [Abstract] [Full Text] [PDF] [Request Permissions]  

Hiromi Hosako, Sally A. Little, Marianne Barrier, and Philip E. Mirkes

Teratogen-Induced Activation of p53 in Early Postimplantation Mouse Embryos
ToxSci Advance Access published on October 26, 2006
Toxicol. Sci. 2007 95: 257-269; doi:10.1093/toxsci/kfl143 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

David B. Warheit, Thomas R. Webb, Vicki L. Colvin, Kenneth L. Reed, and Christie M. Sayes

Pulmonary Bioassay Studies with Nanoscale and Fine-Quartz Particles in Rats: Toxicity is Not Dependent upon Particle Size but on Surface Characteristics
ToxSci Advance Access published on October 9, 2006
Toxicol. Sci. 2007 95: 270-280; doi:10.1093/toxsci/kfl128 [Abstract] [Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

Stephen M. Roberts, John W. Munson, Yvette W. Lowney, and Michael V. Ruby

Relative Oral Bioavailability of Arsenic from Contaminated Soils Measured in the Cynomolgus Monkey
ToxSci Advance Access published on September 27, 2006
Toxicol. Sci. 2007 95: 281-288; doi:10.1093/toxsci/kfl117 [Abstract] [Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Nabil M. Elsayed and Nikolai V. Gorbunov

Pulmonary Biochemical and Histological Alterations after Repeated Low-Level Blast Overpressure Exposures
ToxSci Advance Access published on October 23, 2006
Toxicol. Sci. 2007 95: 289-296; doi:10.1093/toxsci/kfl138 [Abstract] [Full Text] [PDF] [Request Permissions]  

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