Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Mengmeng Wang

Extending the Good Diet, Good Health Paradigm: Modulation of Breast Cancer Resistance Protein (BCRP) by Flavonoids
Toxicol. Sci. 2007 96: 203-205; doi:10.1093/toxsci/kfm014 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW:

Sang Geon Kim and Seung Jin Lee

PI3K, RSK, and mTOR Signal Networks for the GST Gene Regulation
ToxSci Advance Access published on November 22, 2006
Toxicol. Sci. 2007 96: 206-213; doi:10.1093/toxsci/kfl175 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM SERIES:

Elisabeth Lorge, Carine Lambert, Véronique Gervais, Nathalie Becourt-Lhote, Jean-Luc Delongeas, and Nancy Claude

Genetic Toxicity Assessment: Employing the Best Science for Human Safety Evaluation Part II: Performances of the In Vitro Micronucleus Test Compared to the Mouse Lymphoma Assay and the In Vitro Chromosome Aberration Assay
ToxSci Advance Access published on December 27, 2006
Toxicol. Sci. 2007 96: 214-217; doi:10.1093/toxsci/kfl193 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

FORUM:

Thomas M. Price, Susan K. Murphy, and Edward V. Younglai

Perspectives: The Possible Influence of Assisted Reproductive Technologies on Transgenerational Reproductive Effects of Environmental Endocrine Disruptors
ToxSci Advance Access published on December 26, 2006
Toxicol. Sci. 2007 96: 218-226; doi:10.1093/toxsci/kfl196 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Bettina Ebert, Albrecht Seidel, and Alfonso Lampen

Phytochemicals Induce Breast Cancer Resistance Protein in Caco-2 Cells and Enhance the Transport of Benzo[a]pyrene-3-sulfate
ToxSci Advance Access published on October 31, 2006
Toxicol. Sci. 2007 96: 227-236; doi:10.1093/toxsci/kfl147 [Abstract] [Full Text] [PDF] [Request Permissions]  

Robert K. Kuester, Aniko M. Sólyom, Veronica P. Rodriguez, and I. Glenn Sipes

The Effects of Dose, Route, and Repeated Dosing on the Disposition and Kinetics of Tetrabromobisphenol A in Male F-344 Rats
ToxSci Advance Access published on January 18, 2007
Toxicol. Sci. 2007 96: 237-245; doi:10.1093/toxsci/kfm006 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Sandeep Mukhi and Reynaldo Patiño

Effects of Prolonged Exposure to Perchlorate on Thyroid and Reproductive Function in Zebrafish
ToxSci Advance Access published on January 6, 2007
Toxicol. Sci. 2007 96: 246-254; doi:10.1093/toxsci/kfm001 [Abstract] [Full Text] [PDF] [Request Permissions]  

Ksenia Cheshenko, Francois Brion, Yann Le Page, Nathalie Hinfray, Farzad Pakdel, Olivier Kah, Helmut Segner, and Rik I.L. Eggen

Expression of Zebra Fish Aromatase cyp19a and cyp19b Genes in Response to the Ligands of Estrogen Receptor and Aryl Hydrocarbon Receptor
ToxSci Advance Access published on January 18, 2007
Toxicol. Sci. 2007 96: 255-267; doi:10.1093/toxsci/kfm003 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Trine Reistad, Espen Mariussen, Avi Ring, and Frode Fonnum

In Vitro Toxicity of Tetrabromobisphenol-A on Cerebellar Granule Cells: Cell Death, Free Radical Formation, Calcium Influx and Extracellular Glutamate
ToxSci Advance Access published on January 6, 2007
Toxicol. Sci. 2007 96: 268-278; doi:10.1093/toxsci/kfl198 [Abstract] [Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY:

Michael Glei, Anja Schaeferhenrich, Uwe Claussen, Alma Kuechler, Thomas Liehr, Anja Weise, Brigitte Marian, Wolfgang Sendt, and Beatrice L. Pool-Zobel

Comet Fluorescence in situ Hybridization Analysis for Oxidative Stress–Induced DNA Damage in Colon Cancer Relevant Genes
ToxSci Advance Access published on December 27, 2006
Toxicol. Sci. 2007 96: 279-284; doi:10.1093/toxsci/kfl197 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY:

William S. Rickert, Amit H. Trivedi, Rafikali A. Momin, Wendy G. Wright, and John H. Lauterbach

Effect of Smoking Conditions and Methods of Collection on the Mutagenicity and Cytotoxicity of Cigarette Mainstream Smoke
ToxSci Advance Access published on December 22, 2006
Toxicol. Sci. 2007 96: 285-293; doi:10.1093/toxsci/kfl195 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Yin Guo, Robert A. Jolly, Bartley W. Halstead, Thomas K. Baker, John P. Stutz, Melanie Huffman, John N. Calley, Adam West, Hong Gao, George H. Searfoss, Shuyu Li, Armando R. Irizarry, Hui-rong Qian, James L. Stevens, and Timothy P. Ryan

Underlying Mechanisms of Pharmacology and Toxicity of a Novel PPAR Agonist Revealed Using Rodent and Canine Hepatocytes
ToxSci Advance Access published on January 25, 2007
Toxicol. Sci. 2007 96: 294-309; doi:10.1093/toxsci/kfm009 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Francisca Carvajal, Matilde López-Grancha, Montserrat Navarro, Maria del Carmen Sánchez-Amate, and Inmaculada Cubero

Long-Lasting Reductions of Ethanol Drinking, Enhanced Ethanol-Induced Sedation, and Decreased c-fos Expression in the Edinger-Westphal Nucleus in Wistar Rats Exposed to the Organophosphate Chlorpyrifos
ToxSci Advance Access published on December 26, 2006
Toxicol. Sci. 2007 96: 310-320; doi:10.1093/toxsci/kfl194 [Abstract] [Full Text] [PDF] [Request Permissions]  

Mihai D. Niculescu, Renan Wu, Zhong Guo, Kerry Ann da Costa, and Steven H. Zeisel

Diethanolamine Alters Proliferation and Choline Metabolism in Mouse Neural Precursor Cells
ToxSci Advance Access published on January 4, 2007
Toxicol. Sci. 2007 96: 321-326; doi:10.1093/toxsci/kfl200 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Kathila S. Rajapaksa, I. Glenn Sipes, and Patricia B. Hoyer

Involvement of Microsomal Epoxide Hydrolase Enzyme in Ovotoxicity Caused by 7,12-Dimethylbenz[a]anthracene
ToxSci Advance Access published on January 4, 2007
Toxicol. Sci. 2007 96: 327-334; doi:10.1093/toxsci/kfl202 [Abstract] [Full Text] [PDF] [Request Permissions]  

Andrew K. Hotchkiss, Christy S. Lambright, Joseph S. Ostby, Louise Parks-Saldutti, John G. Vandenbergh, and Leon E. Gray, Jr

Prenatal Testosterone Exposure Permanently Masculinizes Anogenital Distance, Nipple Development, and Reproductive Tract Morphology in Female Sprague-Dawley Rats
ToxSci Advance Access published on January 11, 2007
Toxicol. Sci. 2007 96: 335-345; doi:10.1093/toxsci/kfm002 [Abstract] [Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Xiaoyan Yu, Cai Li, Xiaokun Li, and Lu Cai

Rosiglitazone Prevents Advanced Glycation End Products–Induced Renal Toxicity Likely through Suppression of Plasminogen Activator Inhibitor-1
ToxSci Advance Access published on January 29, 2007
Toxicol. Sci. 2007 96: 346-356; doi:10.1093/toxsci/kfm010 [Abstract] [Full Text] [PDF] [Request Permissions]  

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