Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Hartmut Jaeschke

Troglitazone Hepatotoxicity: Are We Getting Closer to Understanding Idiosyncratic Liver Injury?
Toxicol. Sci. 2007 97: 1-3; doi:10.1093/toxsci/kfm021 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW:

Brian D. Guth

Preclinical Cardiovascular Risk Assessment in Modern Drug Development
ToxSci Advance Access published on March 9, 2007
Toxicol. Sci. 2007 97: 4-20; doi:10.1093/toxsci/kfm026 [Extract] [Full Text] [PDF] [Request Permissions]  

FORUM SERIES:

Irene Witte, Ulla Plappert, Hartmut de Wall, and Andreas Hartmann

Genetic Toxicity Assessment: Employing the Best Science for Human Safety Evaluation Part III: The Comet Assay as an Alternative to In Vitro Clastogenicity Tests for Early Drug Candidate Selection
ToxSci Advance Access published on January 4, 2007
Toxicol. Sci. 2007 97: 21-26; doi:10.1093/toxsci/kfl192 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM:

Karluss Thomas, Gary Bannon, Corinne Herouet-Guicheney, Gregory Ladics, Laurie Lee, Sang-Il Lee, Laura Privalle, Barbara Ballmer-Weber, and Stefan Vieths

The Utility of an International Sera Bank for Use in Evaluating the Potential Human Allergenicity of Novel Proteins
ToxSci Advance Access published on March 3, 2007
Toxicol. Sci. 2007 97: 27-31; doi:10.1093/toxsci/kfm020 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Hesham M. Korashy, Anooshirvan Shayeganpour, Dion R. Brocks, and Ayman O.S. El-Kadi

Induction of Cytochrome P450 1A1 by Ketoconazole and Itraconazole but not Fluconazole in Murine and Human Hepatoma Cell Lines
ToxSci Advance Access published on February 5, 2007
Toxicol. Sci. 2007 97: 32-43; doi:10.1093/toxsci/kfm012 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Jihei Nishimura, Yasuaki Dewa, Masako Muguruma, Yuichi Kuroiwa, Hiroaki Yasuno, Tomomi Shima, Mailan Jin, Miwa Takahashi, Takashi Umemura, and Kunitoshi Mitsumori

Effect of Fenofibrate on Oxidative DNA Damage and on Gene Expression Related to Cell Proliferation and Apoptosis in Rats
ToxSci Advance Access published on January 29, 2007
Toxicol. Sci. 2007 97: 44-54; doi:10.1093/toxsci/kfm011 [Abstract] [Full Text] [PDF] [Request Permissions]  

Russell S. Thomas, Linda Pluta, Longlong Yang, and Thomas A. Halsey

Application of Genomic Biomarkers to Predict Increased Lung Tumor Incidence in 2-Year Rodent Cancer Bioassays
ToxSci Advance Access published on February 20, 2007
Toxicol. Sci. 2007 97: 55-64; doi:10.1093/toxsci/kfm023 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Chad R. Blystone, Johnathan Furr, Christy S. Lambright, Kembra L. Howdeshell, Bryce C. Ryan, Vickie S. Wilson, Gerald A. LeBlanc, and Leon Earl Gray, Jr

Prochloraz Inhibits Testosterone Production at Dosages below Those that Affect Androgen-Dependent Organ Weights or the Onset of Puberty in the Male Sprague Dawley Rat
ToxSci Advance Access published on January 18, 2007
Toxicol. Sci. 2007 97: 65-74; doi:10.1093/toxsci/kfm004 [Abstract] [Full Text] [PDF] [Request Permissions]  

Juan Pablo Prestifilippo, Javier Fernández-Solari, Claudia Mohn, Andrea De Laurentiis, Samuel M. McCann, WL Dees, and Valeria Rettori

Effect of Manganese on Luteinizing Hormone–Releasing Hormone Secretion in Adult Male Rats
ToxSci Advance Access published on February 8, 2007
Toxicol. Sci. 2007 97: 75-80; doi:10.1093/toxsci/kfm015 [Abstract] [Full Text] [PDF] [Request Permissions]  

Claire Friry-Santini, David Rouquié, Philippe Kennel, Helen Tinwell, Mohamed Benahmed, and Rémi Bars

Correlation between Protein Accumulation Profiles and Conventional Toxicological Findings Using a Model Antiandrogenic Compound, Flutamide
ToxSci Advance Access published on February 20, 2007
Toxicol. Sci. 2007 97: 81-93; doi:10.1093/toxsci/kfm022 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Erik K. Pacyniak, Xingguo Cheng, Michael L. Cunningham, Kevin Crofton, Curtis D. Klaassen, and Grace L. Guo

The Flame Retardants, Polybrominated Diphenyl Ethers, Are Pregnane X Receptor Activators
ToxSci Advance Access published on February 25, 2007
Toxicol. Sci. 2007 97: 94-102; doi:10.1093/toxsci/kfm025 [Abstract] [Full Text] [PDF] [Request Permissions]  

David S. Miller, Joseph R. Shaw, Caitlin R. Stanton, Roxanna Barnaby, Katherine H. Karlson, Joshua W. Hamilton, and Bruce A. Stanton

MRP2 and Acquired Tolerance to Inorganic Arsenic in the Kidney of Killifish (Fundulus heteroclitus)
ToxSci Advance Access published on February 25, 2007
Toxicol. Sci. 2007 97: 103-110; doi:10.1093/toxsci/kfm030 [Abstract] [Full Text] [PDF] [Request Permissions]  

Joanna Y. Wilson, Randall Wells, Alex Aguilar, Asuncion Borrell, Victoria Tornero, Peter Reijnders, Michael Moore, and John J. Stegeman

Correlates of Cytochrome P450 1A1 Expression in Bottlenose Dolphin (Tursiops truncatus) Integument Biopsies
ToxSci Advance Access published on February 25, 2007
Toxicol. Sci. 2007 97: 111-119; doi:10.1093/toxsci/kfm031 [Abstract] [Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY:

Pamela J. Spencer, Bhaskar B. Gollapudi, and John M. Waechter, Jr

Induction of Micronuclei by Phenol in the Mouse Bone Marrow: I. Association with Chemically Induced Hypothermia
ToxSci Advance Access published on February 27, 2007
Toxicol. Sci. 2007 97: 120-127; doi:10.1093/toxsci/kfm032 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Gregory D. Lyng, Abigail Snyder-Keller, and Richard F. Seegal

Polychlorinated Biphenyl–Induced Neurotoxicity in Organotypic Cocultures of Developing Rat Ventral Mesencephalon and Striatum
ToxSci Advance Access published on February 25, 2007
Toxicol. Sci. 2007 97: 128-139; doi:10.1093/toxsci/kfm027 [Abstract] [Full Text] [PDF] [Request Permissions]  

Patrícia S. Brocardo, Fabrício Assini, Jeferson L. Franco, Pablo Pandolfo, Yara M.R. Müller, Reinaldo N. Takahashi, Alcir L. Dafre, and Ana Lúcia S. Rodrigues

Zinc Attenuates Malathion-Induced Depressant-like Behavior and Confers Neuroprotection in the Rat Brain
ToxSci Advance Access published on February 27, 2007
Toxicol. Sci. 2007 97: 140-148; doi:10.1093/toxsci/kfm024 [Abstract] [Full Text] [PDF] [Request Permissions]  

Heather Klintworth, Kathleen Newhouse, Tingting Li, Won-Seok Choi, Roland Faigle, and Zhengui Xia

Activation of c-Jun N-Terminal Protein Kinase Is a Common Mechanism Underlying Paraquat- and Rotenone-Induced Dopaminergic Cell Apoptosis
ToxSci Advance Access published on February 25, 2007
Toxicol. Sci. 2007 97: 149-162; doi:10.1093/toxsci/kfm029 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Christie M. Sayes, Kenneth L. Reed, and David B. Warheit

Assessing Toxicity of Fine and Nanoparticles: Comparing In Vitro Measurements to In Vivo Pulmonary Toxicity Profiles
ToxSci Advance Access published on February 14, 2007
Toxicol. Sci. 2007 97: 163-180; doi:10.1093/toxsci/kfm018 [Abstract] [Full Text] [PDF] [Request Permissions]  

Juan Carlos Peña-Philippides, Seddigheh Razani-Boroujerdi, Shashi P. Singh, Raymond J. Langley, Neerad C. Mishra, Rogene F. Henderson, and Mohan L. Sopori

Long- and Short-Term Changes in the Neuroimmune-Endocrine Parameters following Inhalation Exposures of F344 Rats to Low-Dose Sarin
ToxSci Advance Access published on February 14, 2007
Toxicol. Sci. 2007 97: 181-188; doi:10.1093/toxsci/kfm017 [Abstract] [Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

Li-Jian Lei, Liang Chen, Tai-Yi Jin, Monica Nordberg, and Xiu-Li Chang

Estimation of Benchmark Dose for Pancreatic Damage in Cadmium-Exposed Smelters
ToxSci Advance Access published on February 14, 2007
Toxicol. Sci. 2007 97: 189-195; doi:10.1093/toxsci/kfm016 [Abstract] [Full Text] [PDF] [Request Permissions]  

SAFETY ASSESSMENT:

James W. Albers, David H. Garabrant, Joel L. Mattsson, Carol J. Burns, Sarah S. Cohen, Cami Sima, Richard P. Garrison, Rudy J. Richardson, and Stanley Berent

Dose-Effect Analyses of Occupational Chlorpyrifos Exposure and Peripheral Nerve Electrophysiology
ToxSci Advance Access published on February 25, 2007
Toxicol. Sci. 2007 97: 196-204; doi:10.1093/toxsci/kfm028 [Abstract] [Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Michie M.K. Ong, Calivarathan Latchoumycandane, and Urs A. Boelsterli

Troglitazone-Induced Hepatic Necrosis in an Animal Model of Silent Genetic Mitochondrial Abnormalities
ToxSci Advance Access published on December 5, 2006
Toxicol. Sci. 2007 97: 205-213; doi:10.1093/toxsci/kfl180 [Abstract] [Full Text] [PDF] [Request Permissions]  

Steven T.S. Lim, Klaus Dragull, Chung-Shih Tang, Harry C. Bittenbender, Jimmy T. Efird, and Pratibha V. Nerurkar

Effects of Kava Alkaloid, Pipermethystine, and Kavalactones on Oxidative Stress and Cytochrome P450 in F-344 Rats
ToxSci Advance Access published on February 27, 2007
Toxicol. Sci. 2007 97: 214-221; doi:10.1093/toxsci/kfm035 [Abstract] [Full Text] [PDF] [Request Permissions]  

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