Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Bernard Weiss

Why Methylmercury Remains a Conundrum 50 Years after Minamata
Toxicol. Sci. 2007 97: 223-225; doi:10.1093/toxsci/kfm047 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW:

Douglas Ball, James Blanchard, David Jacobson-Kram, Roger O McClellan, Timothy McGovern, Daniel L Norwood, WMark Vogel, Ron Wolff, and Lee Nagao

Development of Safety Qualification Thresholds and Their Use in Orally Inhaled and Nasal Drug Product Evaluation
ToxSci Advance Access published on March 16, 2007
Toxicol. Sci. 2007 97: 226-236; doi:10.1093/toxsci/kfm058 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM SERIES:

Stefan Pfuhler, Silvio Albertini, Rolf Fautz, Bernd Herbold, Stephan Madle, Dietmar Utesch, and Albrecht Poth

Genetic Toxicity Assessment: Employing the Best Science for Human Safety Evaluation Part IV:Recommendation of a Working Group of the Gesellschaft fuer Umwelt-Mutationsforschung (GUM) for a Simple and Straightforward Approach to Genotoxicity Testing
ToxSci Advance Access published on February 14, 2007
Toxicol. Sci. 2007 97: 237-240; doi:10.1093/toxsci/kfm019 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM:

Leonard Ritter and Tye E. Arbuckle

Can Exposure Characterization Explain Concurrence or Discordance between Toxicology and Epidemiology?
ToxSci Advance Access published on January 18, 2007
Toxicol. Sci. 2007 97: 241-252; doi:10.1093/toxsci/kfm005 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Ganesh Kumar, Quentin R. Smith, Mitsuhiko Hokari, Jagan Parepally, and Mark W. Duncan

Brain Uptake, Pharmacokinetics, and Tissue Distribution in the Rat of Neurotoxic N-Butylbenzenesulfonamide
ToxSci Advance Access published on March 15, 2007
Toxicol. Sci. 2007 97: 253-264; doi:10.1093/toxsci/kfm057 [Abstract] [Full Text] [PDF] [Request Permissions]  

Teresa L. Leavens, Deepa Rao, Melvin E. Andersen, and David C. Dorman

Evaluating Transport of Manganese from Olfactory Mucosa to Striatum by Pharmacokinetic Modeling
ToxSci Advance Access published on March 19, 2007
Toxicol. Sci. 2007 97: 265-278; doi:10.1093/toxsci/kfm061 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Helen Pui Shan Wong, Le Yu, Emily Kai Yee Lam, Emily Kin Ki Tai, William Ka Kei Wu, and Chi-Hin Cho

Nicotine Promotes Colon Tumor Growth and Angiogenesis through ß-Adrenergic Activation
ToxSci Advance Access published on March 16, 2007
Toxicol. Sci. 2007 97: 279-287; doi:10.1093/toxsci/kfm060 [Abstract] [Full Text] [PDF] [Request Permissions]  

Eva Rached, Gordon C. Hard, Kai Blumbach, Klaus Weber, Regina Draheim, Werner K. Lutz, Sibel Özden, Ulrich Steger, Wolfgang Dekant, and Angela Mally

Ochratoxin A: 13-Week Oral Toxicity and Cell Proliferation in Male F344/N Rats
ToxSci Advance Access published on March 6, 2007
Toxicol. Sci. 2007 97: 288-298; doi:10.1093/toxsci/kfm042 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Marialetizia Penza, Claudia Montani, Annalisa Romani, Pamela Vignolini, Paolo Ciana, Adriana Maggi, Barbara Pampaloni, Luigi Caimi, and Diego Di Lorenzo

Genistein Accumulates in Body Depots and Is Mobilized during Fasting, Reaching Estrogenic Levels in Serum that Counter the Hormonal Actions of Estradiol and Organochlorines
ToxSci Advance Access published on March 3, 2007
Toxicol. Sci. 2007 97: 299-307; doi:10.1093/toxsci/kfm036 [Abstract] [Full Text] [PDF] [Request Permissions]  

Eva D. McLanahan, Jerry L. Campbell, Jr, Duncan C. Ferguson, Barry Harmon, Joan M. Hedge, Kevin M. Crofton, David R. Mattie, Lewis Braverman, Deborah A. Keys, Moiz Mumtaz, and Jeffrey W. Fisher

Low-Dose Effects of Ammonium Perchlorate on the Hypothalamic-Pituitary-Thyroid Axis of Adult Male Rats Pretreated with PCB126
ToxSci Advance Access published on March 22, 2007
Toxicol. Sci. 2007 97: 308-317; doi:10.1093/toxsci/kfm063 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Shusaku Hirakawa, Hisato Iwata, Yoko Takeshita, Eun-Young Kim, Tomohiro Sakamoto, Yuka Okajima, Masao Amano, Nobuyuki Miyazaki, Evgeny A. Petrov, and Shinsuke Tanabe

Molecular Characterization of Cytochrome P450 1A1, 1A2, and 1B1, and Effects of Polychlorinated Dibenzo-p-dioxin, Dibenzofuran, and Biphenyl Congeners on Their Hepatic Expression in Baikal Seal (Pusa sibirica)
ToxSci Advance Access published on March 22, 2007
Toxicol. Sci. 2007 97: 318-335; doi:10.1093/toxsci/kfm066 [Abstract] [Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY:

Lynn H. Pottenger, Linda A. Malley, Matthew S. Bogdanffy, E. Maria Donner, Patricia B. Upton, Yutai Li, Vernon E. Walker, Jack R. Harkema, Marcy I. Banton, and James A. Swenberg

Evaluation of Effects from Repeated Inhalation Exposure of F344 Rats to High Concentrations of Propylene
ToxSci Advance Access published on March 6, 2007
Toxicol. Sci. 2007 97: 336-347; doi:10.1093/toxsci/kfm038 [Abstract] [Full Text] [PDF] [Request Permissions]  

Eric Camyre, Sandra S. Wise, Peter Milligan, Nancy Gordon, Britton Goodale, Megan Stackpole, Natalie Patzlaff, AbouEl-Makarim Aboueissa, and John Pierce Wise, Sr

Ku80 Deficiency Does Not Affect Particulate Chromate–Induced Chromosome Damage and Cytotoxicity in Chinese Hamster Ovary Cells
ToxSci Advance Access published on March 14, 2007
Toxicol. Sci. 2007 97: 348-354; doi:10.1093/toxsci/kfm045 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Stacey E. Anderson, JR Wells, Adam Fedorowicz, Leon F. Butterworth, BJ Meade, and Albert E. Munson

Evaluation of the Contact and Respiratory Sensitization Potential of Volatile Organic Compounds Generated by Simulated Indoor Air Chemistry
ToxSci Advance Access published on March 7, 2007
Toxicol. Sci. 2007 97: 355-363; doi:10.1093/toxsci/kfm043 [Abstract] [Full Text] [PDF] [Request Permissions]  

Irina V. Ustyugova, Laura L. Frost, Knox VanDyke, Kathleen M. Brundage, Rosana Schafer, and John B. Barnett

3,4-Dichloropropionaniline Suppresses Normal Macrophage Function
ToxSci Advance Access published on March 12, 2007
Toxicol. Sci. 2007 97: 364-374; doi:10.1093/toxsci/kfm048 [Abstract] [Full Text] [PDF] [Request Permissions]  

Kimberly J. Fairley, Rich Purdy, Shaun Kearns, Stacey E. Anderson, and BJ Meade

Exposure to the Immunosuppresant, Perfluorooctanoic Acid, Enhances the Murine IgE and Airway Hyperreactivity Response to Ovalbumin
ToxSci Advance Access published on March 15, 2007
Toxicol. Sci. 2007 97: 375-383; doi:10.1093/toxsci/kfm053 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING:

Jeanine L. Page, Mary C. Johnson, Katy M. Olsavsky, Steven C. Strom, Helmut Zarbl, and Curtis J. Omiecinski

Gene Expression Profiling of Extracellular Matrix as an Effector of Human Hepatocyte Phenotype in Primary Cell Culture
ToxSci Advance Access published on February 27, 2007
Toxicol. Sci. 2007 97: 384-397; doi:10.1093/toxsci/kfm034 [Abstract] [Full Text] [PDF] [Request Permissions]  

Sanae Kanno, Akiko Furuyama, and Seishiro Hirano

A Murine Scavenger Receptor MARCO Recognizes Polystyrene Nanoparticles
ToxSci Advance Access published on March 14, 2007
Toxicol. Sci. 2007 97: 398-406; doi:10.1093/toxsci/kfm050 [Abstract] [Full Text] [PDF] [Request Permissions]  

Masaharu Komatsu, Tatsuhiko Furukawa, Ryuji Ikeda, Shota Takumi, Qingqing Nong, Kohji Aoyama, Shin-ichi Akiyama, Dietrich Keppler, and Toru Takeuchi

Involvement of Mitogen-Activated Protein Kinase Signaling Pathways in Microcystin-LR–Induced Apoptosis after its Selective Uptake Mediated by OATP1B1 and OATP1B3
ToxSci Advance Access published on March 16, 2007
Toxicol. Sci. 2007 97: 407-416; doi:10.1093/toxsci/kfm054 [Abstract] [Full Text] [PDF] [Request Permissions]  

G. Frank Gerberick, Jeffrey D. Vassallo, Leslie M. Foertsch, Brad B. Price, Joel G. Chaney, and Jean-Pierre Lepoittevin

Quantification of Chemical Peptide Reactivity for Screening Contact Allergens: A Classification Tree Model Approach
ToxSci Advance Access published on March 30, 2007
Toxicol. Sci. 2007 97: 417-427; doi:10.1093/toxsci/kfm064 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Natalia Onishchenko, Christoffer Tamm, Marie Vahter, Tomas Hökfelt, Jeffrey A. Johnson, Delinda A. Johnson, and Sandra Ceccatelli

Developmental Exposure to Methylmercury Alters Learning and Induces Depression-like Behavior in Male Mice
ToxSci Advance Access published on January 4, 2007
Toxicol. Sci. 2007 97: 428-437; doi:10.1093/toxsci/kfl199 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Yusuke Nakatsu, Yaichiro Kotake, and Shigeru Ohta

Concentration Dependence of the Mechanisms of Tributyltin-Induced Apoptosis
ToxSci Advance Access published on March 6, 2007
Toxicol. Sci. 2007 97: 438-447; doi:10.1093/toxsci/kfm039 [Abstract] [Full Text] [PDF] [Request Permissions]  

Rosa A. González-Polo, Mireia Niso-Santano, Miguel A. Ortíz-Ortíz, Ana Gómez-Martín, José M. Morán, Lourdes García-Rubio, Javier Francisco-Morcillo, Concepción Zaragoza, Germán Soler, and José M. Fuentes

Inhibition of Paraquat-Induced Autophagy Accelerates the Apoptotic Cell Death in Neuroblastoma SH-SY5Y Cells
ToxSci Advance Access published on March 6, 2007
Toxicol. Sci. 2007 97: 448-458; doi:10.1093/toxsci/kfm040 [Abstract] [Full Text] [PDF] [Request Permissions]  

Keith M. Erikson, David C. Dorman, Lawrence H. Lash, and Michael Aschner

Manganese Inhalation by Rhesus Monkeys is Associated with Brain Regional Changes in Biomarkers of Neurotoxicity
ToxSci Advance Access published on March 7, 2007
Toxicol. Sci. 2007 97: 459-466; doi:10.1093/toxsci/kfm044 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Jorge M. Naciff, Gary J. Overmann, Suzanne M. Torontali, Gregory J. Carr, Zubin S. Khambatta, Jay P. Tiesman, Brian D. Richardson, and George P. Daston

Uterine Temporal Response to Acute Exposure to 17-Ethinyl Estradiol in the Immature Rat
ToxSci Advance Access published on March 9, 2007
Toxicol. Sci. 2007 97: 467-490; doi:10.1093/toxsci/kfm046 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Kevin W. Gaido, Janan B. Hensley, Delong Liu, Duncan G. Wallace, Susan Borghoff, Kamin J. Johnson, Susan J. Hall, and Kim Boekelheide

Fetal Mouse Phthalate Exposure Shows that Gonocyte Multinucleation is Not Associated with Decreased Testicular Testosterone
ToxSci Advance Access published on March 14, 2007
Toxicol. Sci. 2007 97: 491-503; doi:10.1093/toxsci/kfm049 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Vu Hoang Dang, Kyung-Chul Choi, and Eui-Bae Jeung

Tetrabromodiphenyl Ether (BDE 47) Evokes Estrogenicity and Calbindin-D9k Expression through an Estrogen Receptor–Mediated Pathway in the Uterus of Immature Rats
ToxSci Advance Access published on March 14, 2007
Toxicol. Sci. 2007 97: 504-511; doi:10.1093/toxsci/kfm051 [Abstract] [Full Text] [PDF] [Request Permissions]  

Chad R. Blystone, Christy S. Lambright, Kembra L. Howdeshell, Johnathan Furr, Robin M. Sternberg, Brian C. Butterworth, Elizabeth J. Durhan, Elizabeth A. Makynen, Gerald T. Ankley, Vickie S. Wilson, Gerald A. LeBlanc, and L. Earl Gray, Jr

Sensitivity of Fetal Rat Testicular Steroidogenesis to Maternal Prochloraz Exposure and the Underlying Mechanism of Inhibition
ToxSci Advance Access published on March 15, 2007
Toxicol. Sci. 2007 97: 512-519; doi:10.1093/toxsci/kfm055 [Abstract] [Full Text] [PDF] [Request Permissions]  

Simon Plummer, Richard M. Sharpe, Nina Hallmark, Isobel Kim Mahood, and Cliff Elcombe

Time-Dependent and Compartment-Specific Effects of In Utero Exposure to Di(n-butyl) Phthalate on Gene/Protein Expression in the Fetal Rat Testis as Revealed by Transcription Profiling and Laser Capture Microdissection
ToxSci Advance Access published on March 22, 2007
Toxicol. Sci. 2007 97: 520-532; doi:10.1093/toxsci/kfm062 [Abstract] [Full Text] [PDF] [Request Permissions]  

SAFETY ASSESSMENT:

Hirotoshi Okumura, Miki Katoh, Toshiro Sawada, Miki Nakajima, Yoshinori Soeno, Hikaru Yabuuchi, Toshihiko Ikeda, Chise Tateno, Katsutoshi Yoshizato, and Tsuyoshi Yokoi

Humanization of Excretory Pathway in Chimeric Mice with Humanized Liver
ToxSci Advance Access published on March 6, 2007
Toxicol. Sci. 2007 97: 533-538; doi:10.1093/toxsci/kfm041 [Abstract] [Full Text] [PDF] [Request Permissions]  

Lisa D. Marroquin, James Hynes, James A. Dykens, Joseph D. Jamieson, and Yvonne Will

Circumventing the Crabtree Effect: Replacing Media Glucose with Galactose Increases Susceptibility of HepG2 Cells to Mitochondrial Toxicants
ToxSci Advance Access published on March 14, 2007
Toxicol. Sci. 2007 97: 539-547; doi:10.1093/toxsci/kfm052 [Abstract] [Full Text] [PDF] [Request Permissions]  

Georgia M. Farris, Glen K. Miller, Gordon K. Wollenberg, Sylvain Molon-Noblot, Christine Chan, and Srinivasa Prahalada

Recombinant Rat and Mouse Growth Hormones: Risk Assessment of Carcinogenic Potential in 2-Year Bioassays in Rats and Mice
ToxSci Advance Access published on March 19, 2007
Toxicol. Sci. 2007 97: 548-561; doi:10.1093/toxsci/kfm059 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

SYSTEMS TOXICOLOGY:

Xuyu Zu, Ruilan Yan, Sarah Robbins, Paulette A. Krishack, Duan-Fang Liao, and Deliang Cao

Reduced 293T Cell Susceptibility to Acrolein Due to Aldose Reductase–like-1 Protein Expression
ToxSci Advance Access published on February 27, 2007
Toxicol. Sci. 2007 97: 562-568; doi:10.1093/toxsci/kfm033 [Abstract] [Full Text] [PDF] [Request Permissions]  

James N. McDougal and Carol M. Garrett

Gene Expression and Target Tissue Dose in the Rat Epidermis after Brief JP-8 and JP-8 Aromatic and Aliphatic Component Exposures
ToxSci Advance Access published on March 3, 2007
Toxicol. Sci. 2007 97: 569-581; doi:10.1093/toxsci/kfm037 [Abstract] [Full Text] [PDF] Supplementary DataSupplementary Data [Request Permissions]  

Glenn S. Belinsky, Ann L. Parke, Qihong Huang, Kerry Blanchard, Supriya Jayadev, Raymond Stoll, Marti Rothe, Luke E. K. Achenie, Rishi R. Gupta, George Y. Wu, and Daniel W. Rosenberg

The Contribution of Methotrexate Exposure and Host Factors on Transcriptional Variance in Human Liver
ToxSci Advance Access published on March 30, 2007
Toxicol. Sci. 2007 97: 582-594; doi:10.1093/toxsci/kfm067 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Matthew T. Martin, Richard J. Brennan, Wenyue Hu, Eser Ayanoglu, Christopher Lau, Hongzu Ren, Carmen R. Wood, J. Christopher Corton, Robert J. Kavlock, and David J. Dix

Toxicogenomic Study of Triazole Fungicides and Perfluoroalkyl Acids in Rat Livers Predicts Toxicity and Categorizes Chemicals Based on Mechanisms of Toxicity
ToxSci Advance Access published on March 22, 2007
Toxicol. Sci. 2007 97: 595-613; doi:10.1093/toxsci/kfm065 [Abstract] [Full Text] [PDF] Supplementary Material [Request Permissions]  

ERRATA:

Justin G. Teeguarden, Paul M. Hinderliter, Galya Orr, Brian D. Thrall, and Joel G. Pounds

Particokinetics In Vitro: Dosimetry Considerations for In Vitro Nanoparticle Toxicology Assessments
Toxicol. Sci. 2007 97: 614; doi:10.1093/toxsci/kfm097 [Extract] [Full Text] [PDF] [Request Permissions]  

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