Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Walter H. Watson and James D. Yager

Arsenic: Extension of its Endocrine Disruption Potential to Interference with Estrogen Receptor-Mediated Signaling
Toxicol. Sci. 2007 98: 1-4; doi:10.1093/toxsci/kfm111 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

SPECIAL CONTRIBUTION:

Allan B. Okey

An Aryl Hydrocarbon Receptor Odyssey to the Shores of Toxicology: The Deichmann Lecture, International Congress of Toxicology-XI
Toxicol. Sci. 2007 98: 5-38; doi:10.1093/toxsci/kfm096 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM SERIES:

Elisabeth Lorge, Véronique Gervais, Nathalie Becourt-Lhote, Catherine Maisonneuve, Jean-Luc Delongeas, and Nancy Claude

Genetic Toxicity Assessment: Employing the Best Science for Human Safety Evaluation Part IV: A Strategy in Genotoxicity Testing in Drug Development: Some Examples
ToxSci Advance Access published on March 15, 2007
Toxicol. Sci. 2007 98: 39-42; doi:10.1093/toxsci/kfm056 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Chester E. Rodriguez, Deirdre A. Mahle, Jeff M. Gearhart, David R. Mattie, John C. Lipscomb, Robert S. Cook, and Hugh A. Barton

Predicting Age-Appropriate Pharmacokinetics of Six Volatile Organic Compounds in the Rat Utilizing Physiologically Based Pharmacokinetic Modeling
ToxSci Advance Access published on April 10, 2007
Toxicol. Sci. 2007 98: 43-56; doi:10.1093/toxsci/kfm082 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Katherine A. Guindon, Leanne L. Bedard, and Thomas E. Massey

Elevation of 8-Hydroxydeoxyguanosine in DNA from Isolated Mouse Lung Cells Following In Vivo Treatment with Aflatoxin B₁
ToxSci Advance Access published on March 30, 2007
Toxicol. Sci. 2007 98: 57-62; doi:10.1093/toxsci/kfm073 [Abstract] [Full Text] [PDF] [Request Permissions]  

Heike Hellmold, Hui Zhang, Ulf Andersson, Bo Blomgren, Tom Holland, Anna-Lena Berg, Marie Elebring, Niclas Sjögren, Krister Bamberg, Björn Dahl, Rolf Westerberg, Birgitta Dillner, Jonathan Tugwood, Jonathan Tugwood, Ruth Roberts, Erik Lundholm, German Camejo, Inger Skånberg, and John Evans

Tesaglitazar, a PPAR/ Agonist, Induces Interstitial Mesenchymal Cell DNA Synthesis and Fibrosarcomas in Subcutaneous Tissues in Rats
ToxSci Advance Access published on April 27, 2007
Toxicol. Sci. 2007 98: 63-74; doi:10.1093/toxsci/kfm094 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Jennifer C. Davey, Jack E. Bodwell, Julie A. Gosse, and Joshua W. Hamilton

Arsenic as an Endocrine Disruptor: Effects of Arsenic on Estrogen Receptor–Mediated Gene Expression In Vivo and in Cell Culture
ToxSci Advance Access published on February 5, 2007
Toxicol. Sci. 2007 98: 75-86; doi:10.1093/toxsci/kfm013 [Abstract] [Full Text] [PDF] [Request Permissions]  

Stine Broeng Metzdorff, Majken Dalgaard, Sofie Christiansen, Marta Axelstad, Ulla Hass, Maria Kristina Kiersgaard, Martin Scholze, Andreas Kortenkamp, and Anne Marie Vinggaard

Dysgenesis and Histological Changes of Genitals and Perturbations of Gene Expression in Male Rats after In Utero Exposure to Antiandrogen Mixtures
ToxSci Advance Access published on April 9, 2007
Toxicol. Sci. 2007 98: 87-98; doi:10.1093/toxsci/kfm079 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Jessica E. Bohonowych and Michael S. Denison

Persistent Binding of Ligands to the Aryl Hydrocarbon Receptor
ToxSci Advance Access published on April 12, 2007
Toxicol. Sci. 2007 98: 99-109; doi:10.1093/toxsci/kfm085 [Abstract] [Full Text] [PDF] [Request Permissions]  

Thomas Bjellaas, Pelle T. Olesen, Henrik Frandsen, Margaretha Haugen, Linn H. Stølen, Jan E. Paulsen, Jan Alexander, Elsa Lundanes, and Georg Becher

Comparison of Estimated Dietary Intake of Acrylamide with Hemoglobin Adducts of Acrylamide and Glycidamide
ToxSci Advance Access published on April 21, 2007
Toxicol. Sci. 2007 98: 110-117; doi:10.1093/toxsci/kfm091 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Akshata S. Nayak, Christopher R. Lage, and Carol H. Kim

Effects of Low Concentrations of Arsenic on the Innate Immune System of the Zebrafish (Danio Rerio)
ToxSci Advance Access published on March 30, 2007
Toxicol. Sci. 2007 98: 118-124; doi:10.1093/toxsci/kfm072 [Abstract] [Full Text] [PDF] [Request Permissions]  

Jennifer J. Schlezinger, Jessica K. Emberley, Stephanie L. Bissonnette, and David H. Sherr

An L-Tyrosine Derivative and PPAR Agonist, GW7845, Activates a Multifaceted Caspase Cascade in Bone Marrow B Cells
ToxSci Advance Access published on March 30, 2007
Toxicol. Sci. 2007 98: 125-136; doi:10.1093/toxsci/kfm071 [Abstract] [Full Text] [PDF] [Request Permissions]  

Jun Gao, Fredine T. Lauer, Leah A. Mitchell, and Scott W. Burchiel

Microsomal Expoxide Hydrolase Is Required for 7,12-Dimethylbenz[a]anthracene (DMBA)–Induced Immunotoxicity in Mice
ToxSci Advance Access published on April 18, 2007
Toxicol. Sci. 2007 98: 137-144; doi:10.1093/toxsci/kfm089 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

William Slikker, Jr, Xiaoju Zou, Charlotte E. Hotchkiss, Rebecca L. Divine, Natalya Sadovova, Nathan C. Twaddle, Daniel R. Doerge, Andrew C. Scallet, Tucker A. Patterson, Joseph P. Hanig, Merle G. Paule, and Cheng Wang

Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey
ToxSci Advance Access published on April 10, 2007
Toxicol. Sci. 2007 98: 145-158; doi:10.1093/toxsci/kfm084 [Abstract] [Full Text] [PDF] [Request Permissions]  

Ambuja S. Bale, Meredith D. Jackson, Quentin Todd Krantz, Vernon A. Benignus, Philip J. Bushnell, Timothy J. Shafer, and William K. Boyes

Evaluating the NMDA-Glutamate Receptor as a Site of Action for Toluene, In Vivo
ToxSci Advance Access published on April 9, 2007
Toxicol. Sci. 2007 98: 159-166; doi:10.1093/toxsci/kfm080 [Abstract] [Full Text] [PDF] [Request Permissions]  

Guang-Di Chen, Lai-Har Chi, Paul J. Kostyniak, and Donald Henderson

Styrene Induced Alterations in Biomarkers of Exposure and Effects in the Cochlea: Mechanisms of Hearing Loss
ToxSci Advance Access published on April 9, 2007
Toxicol. Sci. 2007 98: 167-177; doi:10.1093/toxsci/kfm078 [Abstract] [Full Text] [PDF] [Request Permissions]  

Cary G. Coburn, Margarita C. Currás-Collazo, and Prasada Rao S. Kodavanti

Polybrominated Diphenyl Ethers and ortho-Substituted Polychlorinated Biphenyls as Neuroendocrine Disruptors of Vasopressin Release: Effects during Physiological Activation In Vitro and Structure–Activity Relationships
ToxSci Advance Access published on April 13, 2007
Toxicol. Sci. 2007 98: 178-186; doi:10.1093/toxsci/kfm086 [Abstract] [Full Text] [PDF] [Request Permissions]  

Vasyl Sava, Adriana Velasquez, Shijie Song, and Juan Sanchez-Ramos

Adult Hippocampal Neural Stem/Progenitor Cells In Vitro Are Vulnerable to the Mycotoxin Ochratoxin-A
ToxSci Advance Access published on April 21, 2007
Toxicol. Sci. 2007 98: 187-197; doi:10.1093/toxsci/kfm093 [Abstract] [Full Text] [PDF] [Request Permissions]  

Dejan Milatovic, Zhaobao Yin, Ramesh C. Gupta, Marta Sidoryk, Jan Albrecht, Judy L. Aschner, and Michael Aschner

Manganese Induces Oxidative Impairment in Cultured Rat Astrocytes
ToxSci Advance Access published on April 27, 2007
Toxicol. Sci. 2007 98: 198-205; doi:10.1093/toxsci/kfm095 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Zhimin Shi, Hongxia Zhang, Yang Liu, Muqi Xu, and Jiayin Dai

Alterations in Gene Expression and Testosterone Synthesis in the Testes of Male Rats Exposed to Perfluorododecanoic Acid
ToxSci Advance Access published on March 30, 2007
Toxicol. Sci. 2007 98: 206-215; doi:10.1093/toxsci/kfm070 [Abstract] [Full Text] [PDF] [Request Permissions]  

Miyun Tsai-Turton, Brian T. Luong, Youming Tan, and Ulrike Luderer

Cyclophosphamide-Induced Apoptosis in COV434 Human Granulosa Cells Involves Oxidative Stress and Glutathione Depletion
ToxSci Advance Access published on April 13, 2007
Toxicol. Sci. 2007 98: 216-230; doi:10.1093/toxsci/kfm087 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

J. Grace Wallenborn, John K. McGee, Mette C. Schladweiler, Allen D. Ledbetter, and Urmila P. Kodavanti

Systemic Translocation of Particulate Matter–Associated Metals Following a Single Intratracheal Instillation in Rats
ToxSci Advance Access published on April 13, 2007
Toxicol. Sci. 2007 98: 231-239; doi:10.1093/toxsci/kfm088 [Abstract] [Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

Russell S. Thomas, Bruce C. Allen, Andy Nong, Longlong Yang, Edilberto Bermudez, Harvey J. Clewell, III, and Melvin E. Andersen

A Method to Integrate Benchmark Dose Estimates with Genomic Data to Assess the Functional Effects of Chemical Exposure
ToxSci Advance Access published on April 21, 2007
Toxicol. Sci. 2007 98: 240-248; doi:10.1093/toxsci/kfm092 [Abstract] [Full Text] [PDF] Supplementary Material [Request Permissions]  

SAFETY EVALUATION:

Neera V. Gopee, Dean W. Roberts, Peggy Webb, Christy R. Cozart, Paul H. Siitonen, Alan R. Warbritton, William W. Yu, Vicki L. Colvin, Nigel J. Walker, and Paul C. Howard

Migration of Intradermally Injected Quantum Dots to Sentinel Organs in Mice
ToxSci Advance Access published on April 2, 2007
Toxicol. Sci. 2007 98: 249-257; doi:10.1093/toxsci/kfm074 [Abstract] [Full Text] [PDF] [Request Permissions]  

Sarah H. Tannehill-Gregg, Thomas P. Sanderson, Daniel Minnema, Richard Voelker, Borge Ulland, Samuel M. Cohen, Lora L. Arnold, Beth E. Schilling, C. Robbie Waites, and Mark A. Dominick

Rodent Carcinogenicity Profile of the Antidiabetic Dual PPAR and Agonist Muraglitazar
ToxSci Advance Access published on April 10, 2007
Toxicol. Sci. 2007 98: 258-270; doi:10.1093/toxsci/kfm083 [Abstract] [Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Willem G. E. J. Schoonen, Cathelijne P. A. M. Kloks, Jan-Peter H. T. M. Ploemen, G. Jean Horbach, Martin J. Smit, Pieter Zandberg, Jan-Remt Mellema, Carol Thijssen-van Zuylen, Albert C. Tas, Joop H. J. van Nesselrooij, and Jack T. W. E. Vogels

Sensitivity of ¹H NMR Analysis of Rat Urine in Relation to Toxicometabonomics. Part I: Dose-Dependent Toxic Effects of Bromobenzene and Paracetamol
ToxSci Advance Access published on April 9, 2007
Toxicol. Sci. 2007 98: 271-285; doi:10.1093/toxsci/kfm076 [Abstract] [Full Text] [PDF] [Request Permissions]  

Willem G. E. J. Schoonen, Cathelijne P. A. M. Kloks, Jan-Peter H. T. M. Ploemen, Martin J. Smit, Pieter Zandberg, G. Jean Horbach, Jan-Remt Mellema, Carol Thijssen-vanZuylen, Albert C. Tas, Joop H. J. van Nesselrooij, and Jack T. W. E. Vogels

Uniform Procedure of ¹H NMR Analysis of Rat Urine and Toxicometabonomics Part II: Comparison of NMR Profiles for Classification of Hepatotoxicity
ToxSci Advance Access published on April 9, 2007
Toxicol. Sci. 2007 98: 286-297; doi:10.1093/toxsci/kfm077 [Abstract] [Full Text] [PDF] [Request Permissions]  

Xiaoqing He, Gary X. Lin, Michael G. Chen, Jennifer X. Zhang, and Qiang Ma

Protection against Chromium (VI)–Induced Oxidative Stress and Apoptosis by Nrf2. Recruiting Nrf2 into the Nucleus and Disrupting the Nuclear Nrf2/Keap1 Association
ToxSci Advance Access published on April 9, 2007
Toxicol. Sci. 2007 98: 298-309; doi:10.1093/toxsci/kfm081 [Abstract] [Full Text] [PDF] [Request Permissions]  

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