Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT

Robert E. Chapin

Syzygy's Enlightenments
Toxicol. Sci. 2007 98: 311-312; doi:10.1093/toxsci/kfm134 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW

Get checked abstract Deborah M. Proctor, Nicole M. Gatto, Sandra J. Hong, and Krishna P. Allamneni

Mode-of-Action Framework for Evaluating the Relevance of Rodent Forestomach Tumors in Cancer Risk Assessment
ToxSci Advance Access published on April 10, 2007
Toxicol. Sci. 2007 98: 313-326; doi:10.1093/toxsci/kfm075 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM SERIES

Get checked abstract Lynn H. Pottenger, James S. Bus, and B. Bhaskar Gollapudi

Genetic Toxicity Assessment: Employing the Best Science for Human Safety Evaluation Part VI: When Salt and Sugar and Vegetables Are Positive, How Can Genotoxicity Data Serve to Inform Risk Assessment?
ToxSci Advance Access published on March 25, 2007
Toxicol. Sci. 2007 98: 327-331; doi:10.1093/toxsci/kfm068 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM

Get checked abstract Olwenn V. Martin, John N. Lester, Nikolaos Voulvoulis, and Alan R. Boobis

Human Health and Endocrine Disruption: A Simple Multicriteria Framework for the Qualitative Assessment of End Point–Specific Risks in a Context of Scientific Uncertainty
ToxSci Advance Access published on January 25, 2007
Toxicol. Sci. 2007 98: 332-347; doi:10.1093/toxsci/kfm008 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Charles Timchalk, Ahmed A. Kousba, and Torka S. Poet

An Age-Dependent Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Organophosphorus Insecticide Chlorpyrifos in the Preweanling Rat
ToxSci Advance Access published on May 15, 2007
Toxicol. Sci. 2007 98: 348-365; doi:10.1093/toxsci/kfm119 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

CARCINOGENICITY

Get checked abstract Courtney G. Woods, Amanda M. Burns, Blair U. Bradford, Pamela K. Ross, Oksana Kosyk, James A. Swenberg, Michael L. Cunningham, and Ivan Rusyn

WY-14,643–Induced Cell Proliferation and Oxidative Stress in Mouse Liver are Independent of NADPH Oxidase
ToxSci Advance Access published on May 5, 2007
Toxicol. Sci. 2007 98: 366-374; doi:10.1093/toxsci/kfm104 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract John F. Brown, Jr, Brian A. Mayes, Jay B. Silkworth, and Stephen B. Hamilton

Polychlorinated Biphenyls–Modulated Tumorigenesis in Sprague–Dawley Rats: Correlation with Mixed Function Oxidase Activities and Superoxide (O₂^•–) Formation Potentials and Implied Mode of Action
ToxSci Advance Access published on May 16, 2007
Toxicol. Sci. 2007 98: 375-394; doi:10.1093/toxsci/kfm122 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

ENDOCRINE TOXICOLOGY

Get checked abstract Daniel L. Villeneuve, Lindsey S. Blake, Jeffrey D. Brodin, Katie J. Greene, Iris Knoebl, Ann L. Miracle, Dalma Martinovic, and Gerald T. Ankley

Transcription of Key Genes Regulating Gonadal Steroidogenesis in Control and Ketoconazole- or Vinclozolin-Exposed Fathead Minnows
ToxSci Advance Access published on May 21, 2007
Toxicol. Sci. 2007 98: 395-407; doi:10.1093/toxsci/kfm124 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Vu Hoang Dang, Thi Hoa Nguyen, Kyung-Chul Choi, and Eui-Bae Jeung

A Calcium-Binding Protein, Calbindin-D9k, Is Regulated through an Estrogen-Receptor–Mediated Mechanism following Xenoestrogen Exposure in the GH3 Cell Line
ToxSci Advance Access published on May 15, 2007
Toxicol. Sci. 2007 98: 408-415; doi:10.1093/toxsci/kfm120 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Juan P. Hernandez, Wendong Huang, Laura M. Chapman, Steven Chua, David D. Moore, and William S. Baldwin

The Environmental Estrogen, Nonylphenol, Activates the Constitutive Androstane Receptor
ToxSci Advance Access published on May 5, 2007
Toxicol. Sci. 2007 98: 416-426; doi:10.1093/toxsci/kfm107 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Holly Valentine, Kalyani Amarnath, Venkataraman Amarnath, Weihua Li, Xuncheng Ding, William M. Valentine, and Gaku Ichihara

Globin S-Propyl Cysteine and Urinary N-Acetyl-S-Propylcysteine as Internal Biomarkers of 1-Bromopropane Exposure
ToxSci Advance Access published on May 21, 2007
Toxicol. Sci. 2007 98: 427-435; doi:10.1093/toxsci/kfm126 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Erin L. Hsu, Diana Yoon, Hyun Ho Choi, Feng Wang, Robert T. Taylor, Natalie Chen, Ruixue Zhang, and Oliver Hankinson

A Proposed Mechanism for the Protective Effect of Dioxin against Breast Cancer
ToxSci Advance Access published on May 21, 2007
Toxicol. Sci. 2007 98: 436-444; doi:10.1093/toxsci/kfm125 [Abstract] [Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY

Get checked abstract Volker M. Arlt, Hansruedi Glatt, Gonçalo Gamboa da Costa, Jóhannes Reynisson, Takeji Takamura-Enya, and David H. Phillips

Mutagenicity and DNA Adduct Formation by the Urban Air Pollutant 2-Nitrobenzanthrone
ToxSci Advance Access published on May 4, 2007
Toxicol. Sci. 2007 98: 445-457; doi:10.1093/toxsci/kfm103 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY

Get checked abstract Isabelle Dublineau, Line Grandcolas, Stéphane Grison, Cédric Baudelin, François Paquet, Philippe Voisin, Jocelyne Aigueperse, and Patrick Gourmelon

Modifications of Inflammatory Pathways in Rat Intestine Following Chronic Ingestion of Depleted Uranium
ToxSci Advance Access published on June 12, 2007
Toxicol. Sci. 2007 98: 458-468; doi:10.1093/toxsci/kfm132 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

Get checked abstract Binbin Lu, Laura Kerepesi, Lynne Wisse, Keith Hitchman, and Quanxin Ryan Meng

Cytotoxicity and Gene Expression Profiles in Cell Cultures Exposed to Whole Smoke from Three Types of Cigarettes
ToxSci Advance Access published on May 10, 2007
Toxicol. Sci. 2007 98: 469-478; doi:10.1093/toxsci/kfm112 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Céline Thiébault, Marie Carrière, Sarah Milgram, Angélique Simon, Laure Avoscan, and Barbara Gouget

Uranium Induces Apoptosis and Is Genotoxic to Normal Rat Kidney (NRK-52^E) Proximal Cells
ToxSci Advance Access published on May 23, 2007
Toxicol. Sci. 2007 98: 479-487; doi:10.1093/toxsci/kfm130 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY

Get checked abstract Zhengqin Yang, Sufen Yang, Steven Y. Qian, Jau-Shyong Hong, Maria B. Kadiiska, Raymond W. Tennant, Michael P. Waalkes, and Jie Liu

Cadmium-Induced Toxicity in Rat Primary Mid-brain Neuroglia Cultures: Role of Oxidative Stress from Microglia
ToxSci Advance Access published on May 5, 2007
Toxicol. Sci. 2007 98: 488-494; doi:10.1093/toxsci/kfm106 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Christopher J. Choi, Vellareddy Anantharam, Nathan J. Saetveit, Robert S. Houk, Arthi Kanthasamy, and Anumantha G. Kanthasamy

Normal Cellular Prion Protein Protects against Manganese-Induced Oxidative Stress and Apoptotic Cell Death
ToxSci Advance Access published on May 4, 2007
Toxicol. Sci. 2007 98: 495-509; doi:10.1093/toxsci/kfm099 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Laurence D. Fechter, Caroline Gearhart, Sherry Fulton, Jerry Campbell, Jeffrey Fisher, Kwangsam Na, David Cocker, Alisa Nelson-Miller, Patrick Moon, and Benoit Pouyatos

JP-8 Jet Fuel Can Promote Auditory Impairment Resulting From Subsequent Noise Exposure in Rats
ToxSci Advance Access published on May 4, 2007
Toxicol. Sci. 2007 98: 510-525; doi:10.1093/toxsci/kfm101 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Zahidul Islam, Chidozie J. Amuzie, Jack R. Harkema, and James J. Pestka

Neurotoxicity and Inflammation in the Nasal Airways of Mice Exposed to the Macrocyclic Trichothecene Mycotoxin Roridin A: Kinetics and Potentiation by Bacterial Lipopolysaccharide Coexposure
ToxSci Advance Access published on May 4, 2007
Toxicol. Sci. 2007 98: 526-541; doi:10.1093/toxsci/kfm102 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Laurence D. Fechter, Caroline Gearhart, Sherry Fulton, Jerry Campbell, Jeffrey Fisher, Kwangsam Na, David Cocker, Alisa Nelson-Miller, Patrick Moon, and Benoit Pouyatos

Promotion of Noise-Induced Cochlear Injury by Toluene and Ethylbenzene in the Rat
ToxSci Advance Access published on May 21, 2007
Toxicol. Sci. 2007 98: 542-551; doi:10.1093/toxsci/kfm109 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Katherine L. McDaniel, Stephanie Padilla, Renée S. Marshall, Pamela M. Phillips, Lynda Podhorniak, Yaorong Qian, and Virginia C. Moser

Comparison of Acute Neurobehavioral and Cholinesterase Inhibitory Effects of N-Methylcarbamates in Rat
ToxSci Advance Access published on May 15, 2007
Toxicol. Sci. 2007 98: 552-560; doi:10.1093/toxsci/kfm114 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Richard M. LoPachin, Terrence Gavin, Brian C. Geohagen, and Soma Das

Neurotoxic Mechanisms of Electrophilic Type-2 Alkenes: Soft–Soft Interactions Described by Quantum Mechanical Parameters
ToxSci Advance Access published on May 22, 2007
Toxicol. Sci. 2007 98: 561-570; doi:10.1093/toxsci/kfm127 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Get checked abstract Barbara D. Abbott, Cynthia J. Wolf, Judith E. Schmid, Kaberi P. Das, Robert D. Zehr, Laurence Helfant, Shoji Nakayama, Andrew B. Lindstrom, Mark J. Strynar, and Christopher Lau

Perfluorooctanoic Acid–Induced Developmental Toxicity in the Mouse is Dependent on Expression of Peroxisome Proliferator–Activated Receptor-alpha
ToxSci Advance Access published on May 7, 2007
Toxicol. Sci. 2007 98: 571-581; doi:10.1093/toxsci/kfm110 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Francesca Di Renzo, Maria Luisa Broccia, Erminio Giavini, and Elena Menegola

Relationship between Embryonic Histonic Hyperacetylation and Axial Skeletal Defects in Mouse Exposed to the Three HDAC Inhibitors Apicidin, MS-275, and Sodium Butyrate
ToxSci Advance Access published on May 21, 2007
Toxicol. Sci. 2007 98: 582-588; doi:10.1093/toxsci/kfm115 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Silvia Fuentes, Maria Teresa Colomina, Paloma Vicens, Neus Franco-Pons, and José L. Domingo

Concurrent Exposure to Perfluorooctane Sulfonate and Restraint Stress during Pregnancy in Mice: Effects on Postnatal Development and Behavior of the Offspring
ToxSci Advance Access published on May 15, 2007
Toxicol. Sci. 2007 98: 589-598; doi:10.1093/toxsci/kfm121 [Abstract] [Full Text] [PDF] [Request Permissions]  

LETTERS TO THE EDITOR

Kenny S. Crump

Limitations in the National Cancer Institute Antitumor Drug Screening Database for Evaluating Hormesis
ToxSci Advance Access published on May 29, 2007
Toxicol. Sci. 2007 98: 599-601; doi:10.1093/toxsci/kfm135 [Extract] [Full Text] [PDF] [Request Permissions]  

Edward J. Calabrese, John W. Staudenmayer, Edward J. Stanek, III, and George R. Hoffmann

Hormesis and High Throughput Studies: Crump's Analysis Lacks Credibility
ToxSci Advance Access published on May 29, 2007
Toxicol. Sci. 2007 98: 602-603; doi:10.1093/toxsci/kfm136 [Extract] [Full Text] [PDF] [Request Permissions]  

Stephanie Padilla

Letter to the Editor
ToxSci Advance Access published on June 6, 2007
Toxicol. Sci. 2007 98: 604; doi:10.1093/toxsci/kfm116 [Extract] [Full Text] [PDF] [Request Permissions]  

Ahmed Kousba

Reply to Letter to the Editor
ToxSci Advance Access published on May 16, 2007
Toxicol. Sci. 2007 98: 605-606; doi:10.1093/toxsci/kfm118 [Extract] [Full Text] [PDF] [Request Permissions]  

ERRATUM

Ganesh Kumar, Quentin R. Smith, Mitsuhiko Hokari, Jagan Parepally, and Mark W. Duncan

Brain Uptake, Pharmacokinetics, and Tissue Distribution in the Rat of Neurotoxic N-Butylbenzenesulfonamide
Toxicol. Sci. 2007 98: 607-609; doi:10.1093/toxsci/kfm163 [Extract] [Full Text] [PDF] [Request Permissions]  

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