Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT

Kim Boekelheide

Mixed Messages
Toxicol. Sci. 2007 99: 1-2; doi:10.1093/toxsci/kfm117 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW

Get checked abstract Johnson Thomas, Joseph K. Haseman, Jay I. Goodman, Jerrold M. Ward, Thomas P. Loughran, Jr, and Pamela J. Spencer

A Review of Large Granular Lymphocytic Leukemia in Fischer 344 Rats as an Initial Step Toward Evaluating the Implication of the Endpoint to Human Cancer Risk Assessment
ToxSci Advance Access published on May 22, 2007
Toxicol. Sci. 2007 99: 3-19; doi:10.1093/toxsci/kfm098 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

FORUM SERIES

Get checked abstract Warren W. Ku, Jiri Aubrecht, Robert J. Mauthe, Robert H. Schiestl, and Albert J. Fornace, Jr

Genetic Toxicity Assessment: Employing the Best Science for Human Safety Evaluation Part VII: Why Not Start with a Single Test: A Transformational Alternative to Genotoxicity Hazard and Risk Assessment
ToxSci Advance Access published on June 4, 2007
Toxicol. Sci. 2007 99: 20-25; doi:10.1093/toxsci/kfm147 [Abstract] [Full Text] [PDF] [Supplementary Data] [Supplementary Data] [Request Permissions]  

FORUM

Get checked abstract Jennifer M. Fostel, Lyle Burgoon, Craig Zwickl, Peter Lord, J. Christopher Corton, Pierre R. Bushel, Michael Cunningham, Liju Fan, Stephen W. Edwards, Susan Hester, James Stevens, Weida Tong, Michael Waters, ChiHae Yang, and Raymond Tennant

Toward a Checklist for Exchange and Interpretation of Data from a Toxicology Study
ToxSci Advance Access published on April 17, 2007
Toxicol. Sci. 2007 99: 26-34; doi:10.1093/toxsci/kfm090 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Mary B. Dail, Shane C. Burgess, Edward C. Meek, Jennifer Wagner, Jeffrey Baravik, and Janice E. Chambers

Spatial Distribution of CYP2B1/2 Messenger RNA within the Rat Liver Acinus following Exposure to the Inducers Phenobarbital and Dieldrin
ToxSci Advance Access published on May 21, 2007
Toxicol. Sci. 2007 99: 35-42; doi:10.1093/toxsci/kfm129 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY

Get checked abstract Mari Iida, Colleen H. Anna, Nicole D. Gaskin, Nigel J. Walker, and Theodora R. Devereux

The Putative Tumor Suppressor Tsc-22 is Downregulated Early in Chemically Induced Hepatocarcinogenesis and may be a Suppressor of Gadd45b
ToxSci Advance Access published on May 28, 2007
Toxicol. Sci. 2007 99: 43-50; doi:10.1093/toxsci/kfm138 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Mary E. Kushman, Sandra L. Kabler, Sarfaraz Ahmad, Johannes Doehmer, Charles S. Morrow, and Alan J. Townsend

Protective Efficacy of hGSTM1-1 against B[a]P and (+)- or (–)-B[a]P-7,8-Dihydrodiol Cytotoxicity, Mutagenicity, and Macromolecular Adducts in V79 Cells Coexpressing hCYP1A1
ToxSci Advance Access published on May 24, 2007
Toxicol. Sci. 2007 99: 51-57; doi:10.1093/toxsci/kfm133 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Cecile Michel, Chantal Desdouets, Mohamed Slaoui, Kevin Robert Isaacs, Ruth Angela Roberts, and Eric Boitier

Diethylnitrosamine Initiation Does Not Alter Clofibric Acid–Induced Hepatocarcinogenesis in the Rat
ToxSci Advance Access published on June 30, 2007
Toxicol. Sci. 2007 99: 58-69; doi:10.1093/toxsci/kfm168 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Geniece M. Lehmann and Michael J. McCabe, Jr

Arsenite Slows S Phase Progression via Inhibition of cdc25A Dual Specificity Phosphatase Gene Transcription
ToxSci Advance Access published on June 1, 2007
Toxicol. Sci. 2007 99: 70-78; doi:10.1093/toxsci/kfm142 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Lenka Umannová, Jirina Zatloukalová, Miroslav Machala, Pavel Krcmár, Zuzana Májková, Bernhard Hennig, Alois Kozubík, and Jan Vondrácek

Tumor Necrosis Factor- Modulates Effects of Aryl Hydrocarbon Receptor Ligands on Cell Proliferation and Expression of Cytochrome P450 Enzymes in Rat Liver "Stem-Like" Cells
ToxSci Advance Access published on June 8, 2007
Toxicol. Sci. 2007 99: 79-89; doi:10.1093/toxsci/kfm149 [Abstract] [Full Text] [PDF] [Supplementary Data] [Supplementary Data] [Request Permissions]  

Get checked abstract Mark R. Fielden, Richard Brennan, and Jeremy Gollub

A Gene Expression Biomarker Provides Early Prediction and Mechanistic Assessment of Hepatic Tumor Induction by Nongenotoxic Chemicals
ToxSci Advance Access published on June 8, 2007
Toxicol. Sci. 2007 99: 90-100; doi:10.1093/toxsci/kfm156 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Tomoko Yasui, Eun-Young Kim, Hisato Iwata, Diana G. Franks, Sibel I. Karchner, Mark E. Hahn, and Shinsuke Tanabe

Functional Characterization and Evolutionary History of Two Aryl Hydrocarbon Receptor Isoforms (AhR1 and AhR2) from Avian Species
ToxSci Advance Access published on June 7, 2007
Toxicol. Sci. 2007 99: 101-117; doi:10.1093/toxsci/kfm139 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Junya Matsumoto, Hidetomo Iwano, Hiroki Inoue, Naomi Iwano, Naoko Yamashiki, and Hiroshi Yokota

Metabolic Barrier against Bisphenol A in Rat Uterine Endometrium
ToxSci Advance Access published on June 12, 2007
Toxicol. Sci. 2007 99: 118-125; doi:10.1093/toxsci/kfm148 [Abstract] [Full Text] [PDF] [Supplementary Data] [Supplementary Data] [Request Permissions]  

GENETIC TOXICOLOGY

Get checked abstract Marisol Sandoval, Moisés Morales, Rocío Tapia, Luz del Carmen Alarcón, Montserrat Sordo, Patricia Ostrosky-Wegman, Arturo Ortega, and Esther López-Bayghen

p53 Response to Arsenic Exposure in Epithelial Cells: Protein Kinase B/Akt Involvement
ToxSci Advance Access published on June 12, 2007
Toxicol. Sci. 2007 99: 126-140; doi:10.1093/toxsci/kfm153 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY

Get checked abstract Fei Wang, Stephen M. Roberts, Edward J. Butfiloski, Laurence Morel, and Eric S. Sobel

Acceleration of Autoimmunity by Organochlorine Pesticides: A Comparison of Splenic B-Cell Effects of Chlordecone and Estradiol in (NZBxNZW)F₁ Mice
ToxSci Advance Access published on June 19, 2007
Toxicol. Sci. 2007 99: 141-152; doi:10.1093/toxsci/kfm137 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

Get checked abstract Jim E. Riviere, Ronald E. Baynes, and Xin-Rui Xia

Membrane-Coated Fiber Array Approach for Predicting Skin Permeability of Chemical Mixtures from Different Vehicles
ToxSci Advance Access published on June 8, 2007
Toxicol. Sci. 2007 99: 153-161; doi:10.1093/toxsci/kfm155 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Paul Nioi, Brad K. Perry, Er-Jia Wang, Yi-Zhong Gu, and Ronald D. Snyder

In Vitro Detection of Drug-Induced Phospholipidosis Using Gene Expression and Fluorescent Phospholipid–Based Methodologies
ToxSci Advance Access published on June 12, 2007
Toxicol. Sci. 2007 99: 162-173; doi:10.1093/toxsci/kfm157 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Johanna Lilja, Heléne Lindegren, and Anna Forsby

Surfactant-Induced TRPV1 Activity—A Novel Mechanism for Eye Irritation?
ToxSci Advance Access published on June 16, 2007
Toxicol. Sci. 2007 99: 174-180; doi:10.1093/toxsci/kfm164 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY

Get checked abstract Philip J. Bushnell, Wendy M. Oshiro, Tracey E. Samsam, Vernon A. Benignus, Quentin Todd Krantz, and Elaina M. Kenyon

A Dosimetric Analysis of the Acute Behavioral Effects of Inhaled Toluene in Rats
ToxSci Advance Access published on June 4, 2007
Toxicol. Sci. 2007 99: 181-189; doi:10.1093/toxsci/kfm146 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Get checked abstract Kembra L. Howdeshell, Johnathan Furr, Christy R. Lambright, Cynthia V. Rider, Vickie S. Wilson, and L. Earl Gray, Jr

Cumulative Effects of Dibutyl Phthalate and Diethylhexyl Phthalate on Male Rat Reproductive Tract Development: Altered Fetal Steroid Hormones and Genes
ToxSci Advance Access published on March 30, 2007
Toxicol. Sci. 2007 99: 190-202; doi:10.1093/toxsci/kfm069 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Rao L. Divi, Sarah L. Leonard, Brettania L. Walker, Maryanne M. Kuo, Marie E. Shockley, Marisa C. St Claire, Kunio Nagashima, Steven W. Harbaugh, Jeffrey W. Harbaugh, and Miriam C. Poirier

Erythrocebus patas Monkey Offspring Exposed Perinatally to NRTIs Sustain Skeletal Muscle Mitochondrial Compromise at Birth and at 1 Year of Age
ToxSci Advance Access published on June 1, 2007
Toxicol. Sci. 2007 99: 203-213; doi:10.1093/toxsci/kfm143 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract David R. Bell, Sally Clode, Ming Qi Fan, Alwyn Fernandes, Paul M. D. Foster, Tao Jiang, George Loizou, Alan MacNicoll, Brian G. Miller, Martin Rose, Lang Tran, and Shaun White

Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in the Developing Male Wistar(Han) Rat. I: No Decrease in Epididymal Sperm Count after a Single Acute Dose
ToxSci Advance Access published on June 1, 2007
Toxicol. Sci. 2007 99: 214-223; doi:10.1093/toxsci/kfm140 [Abstract] [Full Text] [PDF] [Supplementary Data] [Supplementary Data] [Request Permissions]  

Get checked abstract David R. Bell, Sally Clode, Ming Qi Fan, Alwyn Fernandes, Paul M. D. Foster, Tao Jiang, George Loizou, Alan MacNicoll, Brian G. Miller, Martin Rose, Lang Tran, and Shaun White

Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in the Developing Male Wistar(Han) Rat. II: Chronic Dosing Causes Developmental Delay
ToxSci Advance Access published on June 1, 2007
Toxicol. Sci. 2007 99: 224-233; doi:10.1093/toxsci/kfm141 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Géraldine Delbès, Clotilde Duquenne, Jessica Szenker, Julie Taccoen, René Habert, and Christine Levacher

Developmental Changes in Testicular Sensitivity to Estrogens throughout Fetal and Neonatal Life
ToxSci Advance Access published on June 14, 2007
Toxicol. Sci. 2007 99: 234-243; doi:10.1093/toxsci/kfm160 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Wenjie He, Robert J. Greenwell, Diane M. Brooks, Lilian Calderón-Garcidueñas, Howard D. Beall, and J. Douglas Coffin

Arsenic Exposure in Pregnant Mice Disrupts Placental Vasculogenesis and Causes Spontaneous Abortion
ToxSci Advance Access published on June 14, 2007
Toxicol. Sci. 2007 99: 244-253; doi:10.1093/toxsci/kfm162 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY

Get checked abstract Paul M. Wise, Sean E. Toczydlowski, and Charles J. Wysocki

Temporal Integration in Nasal Lateralization of Homologous Alcohols
ToxSci Advance Access published on June 4, 2007
Toxicol. Sci. 2007 99: 254-259; doi:10.1093/toxsci/kfm144 [Abstract] [Full Text] [PDF] [Supplementary Data] [Supplementary Data] [Request Permissions]  

Get checked abstract Juha Määttä, Rita Haapakoski, Maili Lehto, Marina Leino, Sari Tillander, Kirsti Husgafvel-Pursiainen, Henrik Wolff, Kai Savolainen, and Harri Alenius

Immunomodulatory Effects of Oak Dust Exposure in a Murine Model of Allergic Asthma
ToxSci Advance Access published on June 19, 2007
Toxicol. Sci. 2007 99: 260-266; doi:10.1093/toxsci/kfm145 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Denise K. Chou, Yinzhi Zhao, Song Gao, Iih-Nan Chou, Paul Toselli, Phillip Stone, and Wande Li

Perturbation of Copper (Cu) Homeostasis and Expression of Cu-Binding Proteins in Cadmium-Resistant Lung Fibroblasts
ToxSci Advance Access published on June 20, 2007
Toxicol. Sci. 2007 99: 267-276; doi:10.1093/toxsci/kfm158 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract David J. Blake, Celeste M. Bolin, David P. Cox, Fernando Cardozo-Pelaez, and Jean C. Pfau

Internalization of Libby Amphibole Asbestos and Induction of Oxidative Stress in Murine Macrophages
ToxSci Advance Access published on June 19, 2007
Toxicol. Sci. 2007 99: 277-288; doi:10.1093/toxsci/kfm166 [Abstract] [Full Text] [PDF] [Request Permissions]  

SAFETY ASSESSMENT

Get checked abstract Nadine Zidek, Juergen Hellmann, Peter-Juergen Kramer, and Philip G. Hewitt

Acute Hepatotoxicity: A Predictive Model Based on Focused Illumina Microarrays
ToxSci Advance Access published on May 22, 2007
Toxicol. Sci. 2007 99: 289-302; doi:10.1093/toxsci/kfm131 [Abstract] [Full Text] [PDF] [Supplementary Data] [Supplementary Data] [Request Permissions]  

SYSTEMS TOXICOLOGY

Get checked abstract Marjoke Heneweer, René Houtman, Jenneke Poortman, Maria Groot, Chris Maliepaard, and Ad Peijnenburg

Estrogenic Effects in the Immature Rat Uterus after Dietary Exposure to Ethinylestradiol and Zearalenone Using a Systems Biology Approach
ToxSci Advance Access published on June 8, 2007
Toxicol. Sci. 2007 99: 303-314; doi:10.1093/toxsci/kfm151 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Richard C. Peffer, Jonathan G. Moggs, Timothy Pastoor, Richard A. Currie, Jayne Wright, Gill Milburn, Felix Waechter, and Ivan Rusyn

Mouse Liver Effects of Cyproconazole, a Triazole Fungicide: Role of the Constitutive Androstane Receptor
ToxSci Advance Access published on June 8, 2007
Toxicol. Sci. 2007 99: 315-325; doi:10.1093/toxsci/kfm154 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Richard P. Beyer, Rebecca C. Fry, Michael R. Lasarev, Lisa A. McConnachie, Lisiane B. Meira, Valerie S. Palmer, Christine L. Powell, Pamela K. Ross, Theo K. Bammler, Blair U. Bradford, Alex B. Cranson, Michael L. Cunningham, Rickie D. Fannin, Gregory M. Higgins, Patrick Hurban, Robert J. Kayton, Kathleen F. Kerr, Oksana Kosyk, Edward K. Lobenhofer, Stella O. Sieber, Portia A. Vliet, Brenda K. Weis, Russel Wolfinger, Courtney G. Woods, Jonathan H. Freedman, Elwood Linney, William K. Kaufmann, Terrance J. Kavanagh, Richard S. Paules, Ivan Rusyn, Leona D. Samson, Peter S. Spencer, William Suk, Raymond J. Tennant, Helmut Zarbl, and Members of the Toxicogenomics Research Consortium

Multicenter Study of Acetaminophen Hepatotoxicity Reveals the Importance of Biological Endpoints in Genomic Analyses
ToxSci Advance Access published on June 11, 2007
Toxicol. Sci. 2007 99: 326-337; doi:10.1093/toxsci/kfm150 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Mathieu Peyrou, Paul E. Hanna, and Alastair E. Cribb

Calpain Inhibition but not Reticulum Endoplasmic Stress Preconditioning Protects Rat Kidneys from p-Aminophenol Toxicity
ToxSci Advance Access published on June 12, 2007
Toxicol. Sci. 2007 99: 338-345; doi:10.1093/toxsci/kfm105 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Mathieu Peyrou, Paul E. Hanna, and Alastair E. Cribb

Cisplatin, Gentamicin, and p-Aminophenol Induce Markers of Endoplasmic Reticulum Stress in the Rat Kidneys
ToxSci Advance Access published on June 12, 2007
Toxicol. Sci. 2007 99: 346-353; doi:10.1093/toxsci/kfm152 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Paul A. Dabisch, Filip To, Edmund K. Kerut, Michael S. Horsmon, and Robert J. Mioduszewski

Multiple Exposures to Sarin Vapor Result in Parasympathetic Dysfunction in the Eye but not the Heart
ToxSci Advance Access published on June 19, 2007
Toxicol. Sci. 2007 99: 354-361; doi:10.1093/toxsci/kfm167 [Abstract] [Full Text] [PDF] [Request Permissions]  

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