Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT

William J. Wolfgang

Exploring Protection from Methotrexate-Induced Teratogenicity in Flies
Toxicol. Sci. 2007 99: 363-365; doi:10.1093/toxsci/kfm198 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW

Get checked abstract Christopher Lau, Katherine Anitole, Colette Hodes, David Lai, Andrea Pfahles-Hutchens, and Jennifer Seed

Perfluoroalkyl Acids: A Review of Monitoring and Toxicological Findings
ToxSci Advance Access published on May 22, 2007
Toxicol. Sci. 2007 99: 366-394; doi:10.1093/toxsci/kfm128 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM

Get checked abstract Hugh A. Barton, Weihsueh A. Chiu, R. Woodrow Setzer, Melvin E. Andersen, A. John Bailer, Frédéric Y. Bois, Robert S. DeWoskin, Sean Hays, Gunnar Johanson, Nancy Jones, George Loizou, Robert C. MacPhail, Christopher J. Portier, Martin Spendiff, and Yu-Mei Tan

Characterizing Uncertainty and Variability in Physiologically Based Pharmacokinetic Models: State of the Science and Needs for Research and Implementation
ToxSci Advance Access published on May 4, 2007
Toxicol. Sci. 2007 99: 395-402; doi:10.1093/toxsci/kfm100 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract Lyle D. Burgoon

Clearing the Standards Landscape: the Semantics of Terminology and their Impact on Toxicogenomics
ToxSci Advance Access published on May 5, 2007
Toxicol. Sci. 2007 99: 403-412; doi:10.1093/toxsci/kfm108 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Jason M. Walraven, David F. Barker, Mark A. Doll, and David W. Hein

Tissue Expression and Genomic Sequences of Rat N-acetyltransferases rNat1, rNat2, rNat3, and Functional Characterization of a Novel rNat3*2 Genetic Variant
ToxSci Advance Access published on June 12, 2007
Toxicol. Sci. 2007 99: 413-421; doi:10.1093/toxsci/kfm159 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract Micaela B. Reddy, Richard John Looney, Mark J. Utell, Kathleen P. Plotzke, and Melvin E. Andersen

Modeling of Human Dermal Absorption of Octamethylcyclotetrasiloxane (D₄) and Decamethylcyclopentasiloxane (D₅)
ToxSci Advance Access published on July 14, 2007
Toxicol. Sci. 2007 99: 422-431; doi:10.1093/toxsci/kfm174 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract Teresa L. Leavens, Benjamin C. Blount, David M. DeMarini, Michael C. Madden, John L. Valentine, Martin W. Case, Lalith K. Silva, Sarah H. Warren, Nancy M. Hanley, and Rex A. Pegram

Disposition of Bromodichloromethane in Humans Following Oral and Dermal Exposure
ToxSci Advance Access published on July 26, 2007
Toxicol. Sci. 2007 99: 432-445; doi:10.1093/toxsci/kfm190 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY

Get checked abstract Jutta Groos, Peter Bannasch, Michael Schwarz, and Annette Kopp-Schneider

Comparison of Mode of Action of Four Hepatocarcinogens: A Model-Based Approach
ToxSci Advance Access published on July 17, 2007
Toxicol. Sci. 2007 99: 446-454; doi:10.1093/toxsci/kfm183 [Abstract] [FREE Full Text] [PDF] [Supplementary Data] [Request Permissions]  

ENDOCRINE TOXICOLOGY

Get checked abstract Edwin Sonneveld, Arjen Jonas, Onno C. Meijer, Abraham Brouwer, and Bart van der Burg

Glucocorticoid-Enhanced Expression of Dioxin Target Genes through Regulation of the Rat Aryl Hydrocarbon Receptor
ToxSci Advance Access published on August 9, 2007
Toxicol. Sci. 2007 99: 455-469; doi:10.1093/toxsci/kfm176 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Ivy D. Moffat, Paul C. Boutros, Trine Celius, Jere Lindén, Raimo Pohjanvirta, and Allan B. Okey

microRNAs in Adult Rodent Liver Are Refractory to Dioxin Treatment
ToxSci Advance Access published on August 13, 2007
Toxicol. Sci. 2007 99: 470-487; doi:10.1093/toxsci/kfm189 [Abstract] [FREE Full Text] [PDF] [Supplementary Data] [Request Permissions]  

IMMUNOTOXICOLOGY

Get checked abstract Nadège Ade, Diane Antonios, Saadia Kerdine-Romer, Fanny Boisleve, Françoise Rousset, and Marc Pallardy

NF-B Plays a Major Role in the Maturation of Human Dendritic Cells Induced by NiSO₄ but not by DNCB
ToxSci Advance Access published on July 16, 2007
Toxicol. Sci. 2007 99: 488-501; doi:10.1093/toxsci/kfm178 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract Jennifer S. Gray and James J. Pestka

Transcriptional Regulation of Deoxynivalenol-Induced IL-8 Expression in Human Monocytes
ToxSci Advance Access published on July 16, 2007
Toxicol. Sci. 2007 99: 502-511; doi:10.1093/toxsci/kfm182 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract Michael J. McCabe, Jr, Michael D. Laiosa, Li Li, Sherri L. Menard, Raymond R. Mattingly, and Allen J. Rosenspire

Low and Nontoxic Inorganic Mercury Burdens Attenuate BCR-Mediated Signal Transduction
ToxSci Advance Access published on July 26, 2007
Toxicol. Sci. 2007 99: 512-521; doi:10.1093/toxsci/kfm188 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

Get checked abstract Joslynn G. Affleck and Virginia K. Walker

Transgenic Rescue of Methotrexate-Induced Teratogenicity in Drosophila melanogaster
ToxSci Advance Access published on May 22, 2007
Toxicol. Sci. 2007 99: 522-531; doi:10.1093/toxsci/kfm123 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract Yi Li, Dahua Pan, Jianzhong Liu, Petra S. Kern, G. Frank Gerberick, Anton J. Hopfinger, and Yufeng J. Tseng

Categorical QSAR Models for Skin Sensitization based upon Local Lymph Node Assay Classification Measures Part 2: 4D-Fingerprint Three-State and Two-2-State Logistic Regression Models
ToxSci Advance Access published on August 3, 2007
Toxicol. Sci. 2007 99: 532-544; doi:10.1093/toxsci/kfm185 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract Eugenia Cordelli, Anna Maria Fresegna, Alessia D'Alessio, Patrizia Eleuteri, Marcello Spanò, Francesca Pacchierotti, and Paola Villani

ReProComet: A New In Vitro Method to Assess DNA Damage in Mammalian Sperm
ToxSci Advance Access published on August 3, 2007
Toxicol. Sci. 2007 99: 545-552; doi:10.1093/toxsci/kfm191 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY

Get checked abstract George C.-T. Jiang, Kristen Tidwell, Beth Ann McLaughlin, Jiyang Cai, Ramesh C. Gupta, Dejan Milatovic, Richard Nass, and Michael Aschner

Neurotoxic Potential of Depleted Uranium—Effects in Primary Cortical Neuron Cultures and in Caenorhabditis elegans
ToxSci Advance Access published on July 16, 2007
Toxicol. Sci. 2007 99: 553-565; doi:10.1093/toxsci/kfm171 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract Maria B. Moretto, Bruna Boff, Jeferson Franco, Thais Posser, Thisa Maite Roessler, Diogo Onofre Souza, Cristina W. Nogueira, Susana Wofchuk, and Joao B. T. Rocha

⁴⁵Ca²⁺ Influx in Rat Brain: Effect of Diorganylchalcogenides Compounds
ToxSci Advance Access published on July 26, 2007
Toxicol. Sci. 2007 99: 566-571; doi:10.1093/toxsci/kfm187 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract William K. Boyes, Mark Bercegeay, Quentin Todd Krantz, Elaina M. Kenyon, Ambuja S. Bale, Timothy J. Shafer, Philip J. Bushnell, and Vernon A. Benignus

Acute Toluene Exposure and Rat Visual Function in Proportion to Momentary Brain Concentration
ToxSci Advance Access published on July 10, 2007
Toxicol. Sci. 2007 99: 572-581; doi:10.1093/toxsci/kfm172 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract Pierre Campo, Katy Maguin, and Robert Lataye

Effects of Aromatic Solvents on Acoustic Reflexes Mediated by Central Auditory Pathways
ToxSci Advance Access published on July 14, 2007
Toxicol. Sci. 2007 99: 582-590; doi:10.1093/toxsci/kfm180 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Get checked abstract David R. Bell, Sally Clode, Ming Qi Fan, Alwyn Fernandes, Paul M. D. Foster, Tao Jiang, George Loizou, Alan MacNicoll, Brian G. Miller, Martin Rose, Lang Tran, and Shaun White

Relationships between Tissue Levels of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), mRNAs, and Toxicity in the Developing Male Wistar(Han) Rat
ToxSci Advance Access published on July 26, 2007
Toxicol. Sci. 2007 99: 591-604; doi:10.1093/toxsci/kfm179 [Abstract] [FREE Full Text] [PDF] [Supplementary Data] [Request Permissions]  

SAFETY ASSESSMENT

Get checked abstract Benjamin D. Phillis, Mahinda Y. Abeywardena, Michael J. Adams, Jennifer A. Kennedy, and Rodney J. Irvine

Nandrolone Potentiates Arrhythmogenic Effects of Cardiac Ischemia in the Rat
ToxSci Advance Access published on July 25, 2007
Toxicol. Sci. 2007 99: 605-611; doi:10.1093/toxsci/kfm186 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract Thomas L. Horn, Karen E. O. Torres, Jennifer M. Naylor, Michael J. Cwik, Carol J. Detrisac, Izet M. Kapetanovic, Ronald A. Lubet, James A. Crowell, and David L. McCormick

Subchronic Toxicity and Toxicogenomic Evaluation of Tamoxifen Citrate + Bexarotene in Female Rats
ToxSci Advance Access published on July 14, 2007
Toxicol. Sci. 2007 99: 612-627; doi:10.1093/toxsci/kfm181 [Abstract] [FREE Full Text] [PDF] [Supplementary Data] [Request Permissions]  

SYSTEMS TOXICOLOGY

Get checked abstract Lisa A. McConnachie, Isaac Mohar, Francesca N. Hudson, Carol B. Ware, Warren C. Ladiges, Carolina Fernandez, Sam Chatterton-Kirchmeier, Collin C. White, Robert H. Pierce, and Terrance J. Kavanagh

Glutamate Cysteine Ligase Modifier Subunit Deficiency and Gender as Determinants of Acetaminophen-Induced Hepatotoxicity in Mice
ToxSci Advance Access published on June 21, 2007
Toxicol. Sci. 2007 99: 628-636; doi:10.1093/toxsci/kfm165 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract Parvaneh Espandiari, Jun Zhang, Barry A. Rosenzweig, Vishal S. Vaidya, Jinchun Sun, Laura Schnackenberg, Eugene H. Herman, Alan Knapton, Joseph V. Bonventre, Richard D. Beger, Karol L. Thompson, and Joseph Hanig

The Utility of a Rodent Model in Detecting Pediatric Drug-Induced Nephrotoxicity
ToxSci Advance Access published on July 17, 2007
Toxicol. Sci. 2007 99: 637-648; doi:10.1093/toxsci/kfm184 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ERRATUM

Denise K. Chou, Yinzhi Zhao, Song Gao, Iih-Nan Chou, Paul Toselli, Phillip Stone, and Wande Li

Perturbation of Copper (Cu) Homeostasis and Expression of Cu-Binding Proteins in Cadmium-Resistant Lung Fibroblasts
Toxicol. Sci. 2007 99: 649; doi:10.1093/toxsci/kfm225 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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