Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT

David B. Warheit

Long-term Inhalation Toxicity Studies with Multiwalled Carbon Nanotubes: Closing the Gaps or Initiating the Debate?
ToxSci Advance Access published on September 26, 2009
Toxicol. Sci. 2009 112: 273-275; doi:10.1093/toxsci/kfp237 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW

FORUM SERIES, PART VIII

James S. Bus and Richard A. Becker

Toxicity Testing in the 21st Century: A View from the Chemical Industry
ToxSci Advance Access published on October 4, 2009
Toxicol. Sci. 2009 112: 297-302; doi:10.1093/toxsci/kfp234 [Extract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY

Get checked abstract Kerstin Gross-Steinmeyer, Patricia L. Stapleton, Julia H. Tracy, Theo K. Bammler, Stephen C. Strom, Donald R. Buhler, and David L. Eaton

Modulation of Aflatoxin B1–Mediated Genotoxicity in Primary Cultures of Human Hepatocytes by Diindolylmethane, Curcumin, and Xanthohumols
ToxSci Advance Access published on September 21, 2009
Toxicol. Sci. 2009 112: 303-310; doi:10.1093/toxsci/kfp206 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Russell S. Thomas, Wenjun Bao, Tzu-Ming Chu, Marina Bessarabova, Tatiana Nikolskaya, Yuri Nikolsky, Melvin E. Andersen, and Russell D. Wolfinger

Use of Short-term Transcriptional Profiles to Assess the Long-term Cancer-Related Safety of Environmental and Industrial Chemicals
ToxSci Advance Access published on September 23, 2009
Toxicol. Sci. 2009 112: 311-321; doi:10.1093/toxsci/kfp233 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Hung-Chi Lin, Tuzz-Ying Song, and Miao-Lin Hu

S-Adenosylhomocysteine Promotes the Invasion of C6 Glioma Cells via Increased Secretion of Matrix Metalloproteinase-2 in Murine Microglial BV2 Cells
ToxSci Advance Access published on September 21, 2009
Toxicol. Sci. 2009 112: 322-330; doi:10.1093/toxsci/kfp218 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY

Get checked abstract Ensa Mathews, Tim D. Braden, Carol S. Williams, John W. Williams, Olga Bolden-Tiller, and Hari O. Goyal

Mal-Development of the Penis and Loss of Fertility in Male Rats Treated Neonatally with Female Contraceptive 17-Ethinyl Estradiol: A Dose-Response Study and a Comparative Study with a Known Estrogenic Teratogen Diethylstilbestrol
ToxSci Advance Access published on September 3, 2009
Toxicol. Sci. 2009 112: 331-343; doi:10.1093/toxsci/kfp207 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Gerald T. Ankley, David C. Bencic, Jenna E. Cavallin, Kathleen M. Jensen, Michael D. Kahl, Elizabeth A. Makynen, Dalma Martinovic, Nathaniel D. Mueller, Leah C. Wehmas, and Daniel L. Villeneuve

Dynamic Nature of Alterations in the Endocrine System of Fathead Minnows Exposed to the Fungicide Prochloraz
ToxSci Advance Access published on September 18, 2009
Toxicol. Sci. 2009 112: 344-353; doi:10.1093/toxsci/kfp227 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Young-Mi Go, Siobhan E. Craige, Michael Orr, Kim M. Gernert, and Dean P. Jones

Gene and Protein Responses of Human Monocytes to Extracellular Cysteine Redox Potential
ToxSci Advance Access published on September 11, 2009
Toxicol. Sci. 2009 112: 354-362; doi:10.1093/toxsci/kfp205 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

IMMUNOTOXICOLOGY

Get checked abstract Haitian Lu, Robert B. Crawford, Colin M. North, Barbara L. F. Kaplan, and Norbert E. Kaminski

Establishment of an Immunoglobulin M Antibody-Forming Cell Response Model for Characterizing Immunotoxicity in Primary Human B Cells
ToxSci Advance Access published on September 18, 2009
Toxicol. Sci. 2009 112: 363-373; doi:10.1093/toxsci/kfp224 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

Get checked abstract Karen Mathijs, Karen J. J. Brauers, Danyel G. J. Jennen, Andre Boorsma, Marcel H. M. van Herwijnen, Ralph W. H. Gottschalk, Jos C. S. Kleinjans, and Joost H. M. van Delft

Discrimination for Genotoxic and Nongenotoxic Carcinogens by Gene Expression Profiling in Primary Mouse Hepatocytes Improves with Exposure Time
ToxSci Advance Access published on September 21, 2009
Toxicol. Sci. 2009 112: 374-384; doi:10.1093/toxsci/kfp229 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Ruili Huang, Noel Southall, Menghang Xia, Ming-Hsuang Cho, Ajit Jadhav, Dac-Trung Nguyen, James Inglese, Raymond R. Tice, and Christopher P. Austin

Weighted Feature Significance: A Simple, Interpretable Model of Compound Toxicity Based on the Statistical Enrichment of Structural Features
ToxSci Advance Access published on October 4, 2009
Toxicol. Sci. 2009 112: 385-393; doi:10.1093/toxsci/kfp231 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

NEUROTOXICOLOGY

Get checked abstract Julie A. Moreno, Elizabeth C. Yeomans, Karin M. Streifel, Bryan L. Brattin, Robert J. Taylor, and Ronald B. Tjalkens

Age-Dependent Susceptibility to Manganese-Induced Neurological Dysfunction
ToxSci Advance Access published on October 7, 2009
Toxicol. Sci. 2009 112: 394-404; doi:10.1093/toxsci/kfp220 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Julie A. Moreno, Karin M. Streifel, Kelly A. Sullivan, Marie E. Legare, and Ronald B. Tjalkens

Developmental Exposure to Manganese Increases Adult Susceptibility to Inflammatory Activation of Glia and Neuronal Protein Nitration
ToxSci Advance Access published on October 7, 2009
Toxicol. Sci. 2009 112: 405-415; doi:10.1093/toxsci/kfp221 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Marcelo Farina, Francisco Campos, Iolanda Vendrell, Jordi Berenguer, Mercedes Barzi, Sebastián Pons, and Cristina Suñol

Probucol Increases Glutathione Peroxidase-1 Activity and Displays Long-Lasting Protection against Methylmercury Toxicity in Cerebellar Granule Cells
ToxSci Advance Access published on September 21, 2009
Toxicol. Sci. 2009 112: 416-426; doi:10.1093/toxsci/kfp219 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Derek A. Drechsel and Manisha Patel

Differential Contribution of the Mitochondrial Respiratory Chain Complexes to Reactive Oxygen Species Production by Redox Cycling Agents Implicated in Parkinsonism
ToxSci Advance Access published on September 18, 2009
Toxicol. Sci. 2009 112: 427-434; doi:10.1093/toxsci/kfp223 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Hyung Gyun Kim, Yong Pil Hwang, Eun Hee Han, Chul Yung Choi, Chang-Yeol Yeo, Jin Young Kim, Kwang Youl Lee, and Hye Gwang Jeong

Metallothionein-III Provides Neuronal Protection through Activation of Nuclear Factor-B via the TrkA/Phosphatidylinositol-3 kinase/Akt Signaling Pathway
ToxSci Advance Access published on September 18, 2009
Toxicol. Sci. 2009 112: 435-449; doi:10.1093/toxsci/kfp230 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Get checked abstract Ruchna Verma and Banalata Mohanty

Early-Life Exposure to Dimethoate-Induced Reproductive Toxicity: Evaluation of Effects on Pituitary-Testicular Axis of Mice
ToxSci Advance Access published on September 2, 2009
Toxicol. Sci. 2009 112: 450-458; doi:10.1093/toxsci/kfp204 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Kenneth A. Voss, Ronald T. Riley, Maurice E. Snook, and Janee Gelineau-van Waes

Reproductive and Sphingolipid Metabolic Effects of Fumonisin B₁ and its Alkaline Hydrolysis Product in LM/Bc Mice: Hydrolyzed Fumonisin B₁ Did Not Cause Neural Tube Defects
ToxSci Advance Access published on September 25, 2009
Toxicol. Sci. 2009 112: 459-467; doi:10.1093/toxsci/kfp215 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY

Get checked abstract Lan Ma-Hock, Silke Treumann, Volker Strauss, Sandra Brill, Frederic Luizi, Michael Mertler, Karin Wiench, Armin O. Gamer, Bennard van Ravenzwaay, and Robert Landsiedel

Inhalation Toxicity of Multiwall Carbon Nanotubes in Rats Exposed for 3 Months
ToxSci Advance Access published on July 7, 2009
Toxicol. Sci. 2009 112: 468-481; doi:10.1093/toxsci/kfp146 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Christine Pohl, Mirko Papritz, Michaela Moisch, Christoph Wübbeke, M. Iris Hermanns, Chiara Uboldi, Jasmin Dei-Anang, Eckhard Mayer, Charles James Kirkpatrick, and Kai Kehe

Acute Morphological and Toxicological Effects in a Human Bronchial Coculture Model after Sulfur Mustard Exposure
ToxSci Advance Access published on September 11, 2009
Toxicol. Sci. 2009 112: 482-489; doi:10.1093/toxsci/kfp211 [Abstract] [Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT

Get checked abstract Ted Simon, Lesa L. Aylward, Christopher R. Kirman, J. Craig Rowlands, and Robert A. Budinsky

Estimates of Cancer Potency of 2,3,7,8-Tetrachlorodibenzo(p)dioxin Using Linear and Nonlinear Dose-Response Modeling and Toxicokinetics
ToxSci Advance Access published on September 23, 2009
Toxicol. Sci. 2009 112: 490-506; doi:10.1093/toxsci/kfp232 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

SAFETY EVALUATION

Get checked abstract Nora Anderson, Tatjana Meier, and Jürgen Borlak

Toxicogenomics Applied to Cultures of Human Hepatocytes Enabled an Identification of Novel Petasites hybridus Extracts for the Treatment of Migraine with Improved Hepatobiliary Safety
ToxSci Advance Access published on September 21, 2009
Toxicol. Sci. 2009 112: 507-520; doi:10.1093/toxsci/kfp216 [Abstract] [Full Text] [PDF] [Supplementary Data] [Supplementary Data] [Request Permissions]  

Get checked abstract Daniel J. Antoine, Dominic P. Williams, Anja Kipar, Rosalind E. Jenkins, Sophie L. Regan, Jean G. Sathish, Neil R. Kitteringham, and B. Kevin Park

High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo
ToxSci Advance Access published on September 25, 2009
Toxicol. Sci. 2009 112: 521-531; doi:10.1093/toxsci/kfp235 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

SYSTEMS TOXICOLOGY

Get checked abstract Mehdi S. Hazari, Najwa Haykal-Coates, Darrell W. Winsett, Daniel L. Costa, and Aimen K. Farraj

A Single Exposure to Particulate or Gaseous Air Pollution Increases the Risk of Aconitine-Induced Cardiac Arrhythmia in Hypertensive Rats
ToxSci Advance Access published on September 11, 2009
Toxicol. Sci. 2009 112: 532-542; doi:10.1093/toxsci/kfp214 [Abstract] [Full Text] [PDF] [Request Permissions]  

COVER

COVER
Toxicol. Sci. 2009 112: NP; doi:10.1093/toxsci/kfp277 [PDF] [Request Permissions]  

STANDING MATERIAL

TABLE OF CONTENTS
Toxicol. Sci. 2009 112: NP; doi:10.1093/toxsci/kfp276 [PDF] [Request Permissions]  

EDITORIAL BOARD
Toxicol. Sci. 2009 112: NP; doi:10.1093/toxsci/kfp278 [PDF] [Request Permissions]  

SUBSCRIPTIONS
Toxicol. Sci. 2009 112: NP; doi:10.1093/toxsci/kfp279 [PDF] [Request Permissions]  

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