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ToxSci Advance Access

ToxSci Advance Access articles are papers in manuscript form that have been accepted by the journal but have not been copyedited or formatted for publication. Copyediting may lead to minor differences between the Advance Access version and the final version of the paper; there may also be differences in the quality of the graphics. More information, including how to cite Advance Access papers, can be found on the Advance Access page.

Advance Access Articles By Date [View by Category]






To see an accepted manuscript, click its [Accepted Manuscript] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

3 July 2009

Systems Toxicology
M. Elena Rodríguez-García, Adoración G. Quiroga, José Castro, Alberto Ortiz, Patricio Aller, and Felicísima Mata
Inhibition of p38-MAPK potentiates cisplatin-induced apoptosis via GSH depletion and increases intracellular drug accumulation in growth-arrested kidney tubular epithelial cells
ToxSci Advance Access published on July 3, 2009.
doi:10.1093/toxsci/kfp145
[Abstract] [Accepted Manuscript] [Request Permissions]  

2 July 2009

Environmental Toxicology
Shaimaa Ahmed, Eivind Valen, Albin Sandelin, and Jason Matthews
Dioxin increases the interaction between aryl hydrocarbon receptor and estrogen receptor alpha at human promoters
ToxSci Advance Access published on July 2, 2009.
doi:10.1093/toxsci/kfp144
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Biotransformation and Toxicokinetics
Neera V. Gopee, Dean W. Roberts, Peggy Webb, Christy R. Cozart, Paul H. Siitonen, John R. Latendresse, Alan R. Warbritton, William W. Yu, Vicki L. Colvin, Nigel J. Walker, and Paul C. Howard
Quantitative Determination of Skin Penetration of PEG-coated CdSe Quantum Dots in Dermabraded but not Intact SKH-1 Hairless Mouse Skin
ToxSci Advance Access published on July 2, 2009.
doi:10.1093/toxsci/kfp139
[Abstract] [Accepted Manuscript] [Request Permissions]  

30 June 2009

Genetic Toxicology
Yang-Ming Tseng, Shih-Meng Tsai, Sheng-Yi Chen, Chun-Chin Lin, Yi-Ru Jin, Wei-Hao Yeh, Yi-Ru Wu, Ing-Jun Chen, Jang-Hwa Lee, and Li-Yu Tsai
Roles of the Genetic Polymorphisms of Alcohol-metabolizing Enzymes on the Immunology in High-risk Drinkers
ToxSci Advance Access published on June 30, 2009.
doi:10.1093/toxsci/kfp143
[Abstract] [Accepted Manuscript] [Request Permissions]  

REVIEW
Steven O. Simmons, Chun-Yang Fan, and Ram Ramabhadran
Cellular Stress Response Pathway System as a Sentinel Ensemble in Toxicological Screening
ToxSci Advance Access published on June 30, 2009.
doi:10.1093/toxsci/kfp140
[Abstract] [Accepted Manuscript] [Request Permissions]  

29 June 2009

Neurotoxicology
Shenfeng Qiu, Azadeh K. Jebelli, John H. Ashe, and Margarita C. Currás-Collazo
Domoic acid induces a long-lasting enhancement of CA1 field responses and impairs tetanus-induced long-term potentiation in rat hippocampal slices
ToxSci Advance Access published on June 29, 2009.
doi:10.1093/toxsci/kfp141
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Reproductive and Developmental Toxicology
Chad R. Blystone, Christy S. Lambright, Mary C. Cardon, Johnathan Furr, Cynthia V. Rider, Phillip C. Hartig, Vickie S. Wilson, and L. Earl Gray Jr
Cumulative and antagonistic effects of a mixture of the antiandrogens vinclozolin and iprodione in the pubertal male rat
ToxSci Advance Access published on June 29, 2009.
doi:10.1093/toxsci/kfp137
[Abstract] [Accepted Manuscript] [Request Permissions]  

26 June 2009

Article
Mitchell B. Rosen, Christopher Lau, and J. Christopher Corton
Does Exposure to Perfluoroalkyl Acids Present a Risk to Human Health?
ToxSci Advance Access published on June 26, 2009.
doi:10.1093/toxsci/kfp142
[Accepted Manuscript] [Request Permissions]  

24 June 2009

In Vitro Toxicology and Alternative Testing
Jau-Shyang Huang, Lea-Yea Chuang, Jinn-Yuh Guh, and Yann-Jia Huang
Effects of Nitric Oxide and Antioxidants on Advanced Glycation End Products-Induced Hypertrophic Growth in Human Renal Tubular Cells
ToxSci Advance Access published on June 24, 2009.
doi:10.1093/toxsci/kfp134
[Abstract] [Accepted Manuscript] [Request Permissions]  

22 June 2009

Carcinogenicity
Xinzhu Pu, Lisa M. Kamendulis, and James E. Klaunig
Acrylonitrile-induced Oxidative Stress and Oxidative DNA Damage in Male Sprague-Dawley Rats
ToxSci Advance Access published on June 22, 2009.
doi:10.1093/toxsci/kfp133
[Abstract] [Accepted Manuscript] [Request Permissions]  

19 June 2009

Environmental Toxicology
Peijun Zuo, Wei Qu, Ryan N. Cooper, Robert A. Goyer, Bhalchandra A. Diwan, and Michael P. Waalkes
Potential Role of {alpha}-Synuclein and Metallothionein in Lead-Induced Inclusion Body Formation
ToxSci Advance Access published on June 19, 2009.
doi:10.1093/toxsci/kfp132
[Abstract] [Accepted Manuscript] [Request Permissions]  

18 June 2009

In Vitro Toxicology and Alternative Testing
Jia-Long Fang and Frederick A. Beland
Long-term exposure to zidovudine delays cell cycle progression, induces apoptosis, and decreases telomerase activity in human hepatocytes
ToxSci Advance Access published on June 18, 2009.
doi:10.1093/toxsci/kfp136
[Abstract] [Accepted Manuscript] [Request Permissions]  

Endocrine Toxicology
K. Pogrmic, S. Fa, V. Dakic, S. Kaisarevic, and R. Kovacevic
Atrazine Oral Exposure of Peripubertal Male Rats Down-Regulates Steroidogenesis Gene Expression in Leydig Cells
ToxSci Advance Access published on June 18, 2009.
doi:10.1093/toxsci/kfp135
[Abstract] [Accepted Manuscript] [Request Permissions]  

In Vitro Toxicology and Alternative Testing
Chayma Bouaziz, Cécile Martel, Ossama Sharaf el dein, Salwa Abid-Essefi, Catherine Brenner, Christophe Lemaire, and Hassen Bacha
Fusarial toxin-induced toxicity in cultured cells and in isolated mitochondria involves PTPC-dependent activation of the mitochondrial pathway of apoptosis
ToxSci Advance Access published on June 18, 2009.
doi:10.1093/toxsci/kfp117
[Abstract] [Accepted Manuscript] [Request Permissions]  

17 June 2009

Neurotoxicology
Tairan Xing, Liang Chen, Yanan Tao, Ming Wang, Jutao Chen, and Di-Yun Ruan
Effects of Decabrominated Diphenyl Ether (PBDE 209) Exposure at Different Developmental Periods on Synaptic Plasticity in the Dentate Gyrus of Adult Rats in vivo
ToxSci Advance Access published on June 17, 2009.
doi:10.1093/toxsci/kfp114
[Abstract] [Accepted Manuscript] [Request Permissions]  

15 June 2009

Reproductive and Developmental Toxicology
Nigel Noriega, Kembra L. Howdeshell, Jonathan Furr, Christy R. Lambright, Vickie S. Wilson, and L. Earl Gray Jr
Pubertal administration of DEHP delays puberty, suppresses testosterone production and inhibits reproductive tract development in male Sprague-Dawley and Long-Evans Rats
ToxSci Advance Access published on June 15, 2009.
doi:10.1093/toxsci/kfp129
[Abstract] [Accepted Manuscript] [Request Permissions]  

12 June 2009

Review
Samuel M. Cohen, Richard D. Storer, Kay A. Criswell, Nancy G. Doerrer, Vicki L. Dellarco, David G. Pegg, Zbigniew W. Wojcinski, David E. Malarkey, Abigail C. Jacobs, James E. Klaunig, James A. Swenberg, and Jon C. Cook
Hemangiosarcoma in Rodents: Mode-of-Action Evaluation and Human Relevance
ToxSci Advance Access published on June 12, 2009.
doi:10.1093/toxsci/kfp131
[Abstract] [Accepted Manuscript] [Request Permissions]  

Biotransformation and Toxicokinetics
Yukie Yanagiba, Yuki Ito, Michihiro Kamijima, Frank J. Gonzalez, and Tamie Nakajima
Octachlorostyrene Induces Cytochrome P450, UDP-glucuronosyltransferase and Sulfotransferase via the Aryl Hydrocarbon Receptor and Constitutive Androstane Receptor
ToxSci Advance Access published on June 12, 2009.
doi:10.1093/toxsci/kfp130
[Abstract] [Accepted Manuscript] [Request Permissions]  

10 June 2009

Carcinogenicity
M. Chopra, A. M. Dharmarajan, G. Meiss, and D. Schrenk
Inhibition of UV-C light-induced apoptosis in liver cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). -Inhibition of apoptosis by TCDD-
ToxSci Advance Access published on June 10, 2009.
doi:10.1093/toxsci/kfp128
[Abstract] [Accepted Manuscript] [Request Permissions]  

Biotransformation and Toxicokinetics
Sarah J. White, Elizabeth M. Laurenzana, W. Brooks Gentry, Howard P. Hendrickson, D. Keith Williams, Keith W. Ward, and S. Michael Owens
Vulnerability to (+)-Methamphetamine Effects and the Relationship to Drug Disposition in Pregnant Rats during Chronic Infusion
ToxSci Advance Access published on June 10, 2009.
doi:10.1093/toxsci/kfp127
[Abstract] [Accepted Manuscript] [Request Permissions]  

Neurotoxicology
Neal C. Burton, Jay S. Schneider, Tore Syversen, and Tomás R. Guilarte
Effects of Chronic Manganese Exposure on Glutamatergic and GABAergic Neurotransmitter Markers in the Non-Human Primate Brain
ToxSci Advance Access published on June 10, 2009.
doi:10.1093/toxsci/kfp124
[Abstract] [Accepted Manuscript] [Request Permissions]  

5 June 2009

Endocrine Toxicology
Shao-hua Wang, Zi-lin Sun, Yi-jing Guo, Yang Yuan, and Bing-quan Yang
Diabetes impairs hippocampal function via advanced-glycation-end product–mediated new neuron generation in animals with diabetes-related depression
ToxSci Advance Access published on June 5, 2009.
doi:10.1093/toxsci/kfp126
[Abstract] [Accepted Manuscript] [Request Permissions]  

Reproductive and Developmental Toxicology
Betina J. Lew, Loretta L. Collins, Michael A. O'Reilly, and B. Paige Lawrence
Activation of the aryl hydrocarbon receptor (AhR) during different critical windows in pregnancy alters mammary epithelial cell proliferation and differentiation
ToxSci Advance Access published on June 5, 2009.
doi:10.1093/toxsci/kfp125
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

In Vitro Toxicology and Alternative Testing
Menghang Xia, Ruili Huang, Yi Sun, Gregg L. Semenza, Shelley Force Aldred, Kristine L. Witt, James Inglese, Raymond R. Tice, and Christopher P. Austin
Identification of Chemical Compounds that Induce HIF-1{alpha} Activity
ToxSci Advance Access published on June 5, 2009.
doi:10.1093/toxsci/kfp123
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

3 June 2009

Reproductive and Developmental Toxicology
Matthew J. Jenny, Sibel Karchner, Diana Franks, Bruce W. Woodin, John J. Stegeman, and Mark E. Hahn
Distinct roles of two zebrafish AHR repressors (AHRRa and AHRRb) in embryonic development and regulating the response to TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin)
ToxSci Advance Access published on June 3, 2009.
doi:10.1093/toxsci/kfp116
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

1 June 2009

Carcinogenicity
Fu-Jun Liu, Aaron Barchowsky, and Patricia L Opresko
The Werner Syndrome Protein Functions in Repair of Cr (VI)-induced Replication Associated DNA Damage
ToxSci Advance Access published on June 1, 2009.
doi:10.1093/toxsci/kfp104
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

29 May 2009

Reproductive and Developmental Toxicology
L. Earl Gray Jr, Norman J. Barlow, Kembra L. Howdeshell, Joseph S. Ostby, Johnathan R. Furr, and Clark L. Gray
TRANSGENERATIONAL EFFECTS OF DI (2-ETHYLHEXYL) PHTHALATE IN THE MALE CRL: CD(SD) RAT: ADDED VALUE OF ASSESSING MULTIPLE OFFSPRING PER LITTER
ToxSci Advance Access published on May 29, 2009.
doi:10.1093/toxsci/kfp109
[Abstract] [Accepted Manuscript] [Request Permissions]  

Carcinogenicity
Jennifer M. Phillips, Lyle D. Burgoon, and Jay I. Goodman
The Constitutive Active/Androstane Receptor (CAR) Facilitates Unique Phenobarbital (PB)-Induced Expression Changes of Genes Involved in Key Pathways in Precancerous Liver and Liver Tumors
ToxSci Advance Access published on May 29, 2009.
doi:10.1093/toxsci/kfp108
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

28 May 2009

Biotransformation and Toxicokinetics
Zoltán Gregus, Goedele Roos, Paul Geerlings, and Balázs Németi
Mechanism of Thiol-Supported Arsenate Reduction Mediated by Phosphorolytic-Arsenolytic Enzymes. • II. Enzymatic Formation of Arsenylated Products Susceptible for Reduction to Arsenite by Thiols
ToxSci Advance Access published on May 28, 2009.
doi:10.1093/toxsci/kfp113
[Abstract] [Accepted Manuscript] [Request Permissions]  

Carcinogenicity
Yasushi Kawasaki, Yoko Hirabayashi, Toyozo Kaneko, Jun Kanno, Yukio Kodama, Yuuko Matsushima, Yukio Ogawa, Minoru Saitoh, Kiyoshi Sekita, Osayuki Uchida, Takashi Umemura, Byung-Il Yoon, and Tohru Inoue
Benzene-induced hematopoietic neoplasms including myeloid leukemia in Trp53-deficient C57BL/6 and C3H/He mice
ToxSci Advance Access published on May 28, 2009.
doi:10.1093/toxsci/kfp107
[Abstract] [Accepted Manuscript] [Request Permissions]  

27 May 2009

Biotransformation and Toxicokinetics
Ronnie L. Yeager, Scott A. Reisman, Lauren M. Aleksunes, and Curtis D. Klaassen
Introducing the ‘TCDD Inducible AhR-Nrf2 Gene Battery’
ToxSci Advance Access published on May 27, 2009.
doi:10.1093/toxsci/kfp115
[Abstract] [Accepted Manuscript] [Request Permissions]  

Biotransformation and Toxicokinetics
Balázs Németi and Zoltán Gregus
Mechanism of Thiol-Supported Arsenate Reduction Mediated by Phosphorolytic-Arsenolytic Enzymes. I. The Role of Arsenolysis
ToxSci Advance Access published on May 27, 2009.
doi:10.1093/toxsci/kfp112
[Abstract] [Accepted Manuscript] [Request Permissions]  

Environmental Toxicology
Xiongjie Shi, Leo W. Y. Yeung, Paul K. S. Lam, Rudolf S. S. Wu, and Bingsheng Zhou
Protein Profiles in Zebrafish (Danio rerio) Embryos Exposed to PFOS
ToxSci Advance Access published on May 27, 2009.
doi:10.1093/toxsci/kfp111
[Abstract] [Accepted Manuscript] [Request Permissions]  

25 May 2009

Risk Assessment
Nigel J. Walker and John R. Bucher
"A 21st century paradigm for evaluating the health hazards of nanoscale materials?"
ToxSci Advance Access published on May 25, 2009.
doi:10.1093/toxsci/kfp106
[Abstract] [Accepted Manuscript] [Request Permissions]  

22 May 2009

Neurotoxicology
Chris N. Glover, Dongling Zheng, Shalini Jayashankar, Gillian D. Sales, Christer Hogstrand, and Anne-Katrine Lundebye
Methylmercury speciation influences brain gene expression and behaviour in gestationally-exposed mice pups
ToxSci Advance Access published on May 22, 2009.
doi:10.1093/toxsci/kfp105
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Genetic Toxicology
Heidrun Ellinger-Ziegelbauer, Jennifer M Fostel, Chinami Aruga, Daniel Bauer, Eric Boitier, Shibing Deng, Donna Dickinson, Anne-Celine Le Fevre, Albert J. Fornace Jr, Olivier Grenet, Yizhong Gu, Jean-Christophe Hoflack, Masako Shiiyama, Roger Smith, Ronald D. Snyder, Catherine Spire, Gotaro Tanaka, and Jiri Aubrecht
Characterization and interlaboratory comparison of a gene expression signature for differentiating genotoxic mechanisms
ToxSci Advance Access published on May 22, 2009.
doi:10.1093/toxsci/kfp103
[Abstract] [Accepted Manuscript] [Request Permissions]  

18 May 2009

In Vitro Toxicology and Alternative Testing
Hongyu Zhang, Xiaoxia Kong, Jinsong Kang, Jing Su, Yang Li, Jiateng Zhong, and Liankun Sun
Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells
ToxSci Advance Access published on May 18, 2009.
doi:10.1093/toxsci/kfp101
[Abstract] [Accepted Manuscript] [Request Permissions]  

15 May 2009

Biotransformation and Toxicokinetics
Ans Punt, Alicia Paini, Marelle G. Boersma, Andreas P. Freidig, Thierry Delatour, Gabriele Scholz, Benoît Schilter, Peter J. van Bladeren, and Ivonne M.C.M. Rietjens
Use of physiologically based biokinetic (PBBK) modeling to study estragole bioactivation and detoxification in humans as compared to male rats.
ToxSci Advance Access published on May 15, 2009.
doi:10.1093/toxsci/kfp102
[Abstract] [Accepted Manuscript] [Request Permissions]  

8 May 2009

Respiratory Toxicology
J. Muller, M. Delos, N. Panin, V. Rabolli, F. Huaux, and D. Lison
Absence of carcinogenic response to multi-wall carbon nanotubes in a 2-year bioassay in the peritoneal cavity of the rat
ToxSci Advance Access published on May 8, 2009.
doi:10.1093/toxsci/kfp100
[Abstract] [Accepted Manuscript] [Request Permissions]  

In Vitro Toxicology and Alternative Testing
Tai-Yu Chiu, Hsiao-Chuan Teng, Ping-Chun Huang, Fu-Jen Kao, and De-Ming Yang
Dominant Role of Orai1 with STIM1 on the Cytosolic Entry and Cytotoxicity of Lead Ions
ToxSci Advance Access published on May 8, 2009.
doi:10.1093/toxsci/kfp099
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

7 May 2009

Systems Toxicology
Amber K. Goetz and David J. Dix
Mode of Action for Reproductive and Hepatic Toxicity Inferred from a Genomic Study of Triazole Antifungals
ToxSci Advance Access originally published on May 7, 2009. This version published May 25, 2009.
doi:10.1093/toxsci/kfp098
[Abstract] [Accepted Manuscript] [Request Permissions]  

30 April 2009

Environmental Toxicology
James A. Bjork and Kendall B. Wallace
Structure-Activity Relationships and Human Relevance for Perfluoroalkyl Acid-induced Transcriptional Activation of Peroxisome Proliferation in Liver Cell Cultures
ToxSci Advance Access published on April 30, 2009.
doi:10.1093/toxsci/kfp093
[Abstract] [Accepted Manuscript] [Request Permissions]  

30 January 2009

Environmental Toxicology
Zhekang Ying, Thomas Kampfrath, George Thurston, Britten Farrar, Mort Lippmann, Aixia Wang, Qinghua Sun, Lung Chi Chen, and Sanjay Rajagopalan
Ambient Particulates Alter Vascular Function through Induction of Reactive Oxygen and Nitrogen Species
ToxSci Advance Access originally published on January 30, 2009. This version published April 15, 2009.
doi:10.1093/toxsci/kfp004
[Abstract] [Accepted Manuscript] [Request Permissions]  

To see an accepted manuscript, click its [Accepted Manuscript] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.