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ToxSci Advance Access

ToxSci Advance Access articles are papers in manuscript form that have been accepted by the journal but have not been copyedited or formatted for publication. Copyediting may lead to minor differences between the Advance Access version and the final version of the paper; there may also be differences in the quality of the graphics. More information, including how to cite Advance Access papers, can be found on the Advance Access page.

Advance Access Articles By Date [View by Category]






To see an accepted manuscript, click its [Accepted Manuscript] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

19 November 2009

Molecular Toxicology
Ellen C. Henry, Stephen L. Welle, and Thomas A. Gasiewicz
TCDD and a putative endogenous AhR ligand, ITE, elicit the same immediate changes in gene expression in mouse lung fibroblasts
ToxSci Advance Access published on November 19, 2009.
doi:10.1093/toxsci/kfp285
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

18 November 2009

Neurotoxicology
Ana Paula Ardais, Giordano G. Viola, Marcelo S. Costa, Fernanda Nunes, Guilherme A. Behr, Fábio Klamt, José Claudio F. Moreira, Diogo O. Souza, João Batista T. Rocha, and Lisiane O. Porciúncula
Acute treatment with diphenyl diselenide inhibits glutamate uptake into rat hippocampal slices and modifies glutamate transporters, SNAP-25 and GFAP immunocontent
ToxSci Advance Access published on November 18, 2009.
doi:10.1093/toxsci/kfp282
[Abstract] [Accepted Manuscript] [Request Permissions]  

17 November 2009

Biotransformation and Toxicokinetics
Jordan Ned Smith, Jun Wang, Yuehe Lin, and Charles Timchalk
Pharmacokinetics of the chlorpyrifos metabolite 3,5,6-trichloro-2-pyridinol (TCPy) in rat saliva
ToxSci Advance Access published on November 17, 2009.
doi:10.1093/toxsci/kfp283
[Abstract] [Accepted Manuscript] [Request Permissions]  

Molecular Toxicology
Shashikiran Donthamsetty, William Bowen, Wendy Mars, Vishakha Bhave, Jian-Hua Luo, Cary Wu, Jennifer Hurd, Ann Orr, Aaron Bell, and George Michalopoulos
Liver Specific Ablation of Integrin Linked Kinase (ILK) in Mice Results in Enhanced and Prolonged Cell Proliferation and Hepatomegaly after Phenobarbital Administration
ToxSci Advance Access published on November 17, 2009.
doi:10.1093/toxsci/kfp281
[Abstract] [Accepted Manuscript] [Request Permissions]  

Biotransformation and Toxicokinetics
Ans Punt, Suzanne M. Jeurissen, Marelle G. Boersma, Thierry Delatour, Gabriele Scholz, Benoît Schilter, Peter J. van Bladeren, and Ivonne M.C.M. Rietjens
Evaluation of human interindividual variation in bioactivation of estragole using physiologically based biokinetic (PBBK) modeling
ToxSci Advance Access published on November 17, 2009.
doi:10.1093/toxsci/kfp272
[Abstract] [Accepted Manuscript] [Request Permissions]  

16 November 2009

Environmental Toxicology
Douglas J. Fort, Robert L. Rogers, Joseph W. Gorsuch, Lisa T. Navarro, Robert Peter, and James R. Plautz
Triclosan and Anuran Metamorphosis: No Effect on Thyroid-Mediated Metamorphosis in Xenopus laevis
ToxSci Advance Access published on November 16, 2009.
doi:10.1093/toxsci/kfp280
[Abstract] [Accepted Manuscript] [Request Permissions]  

13 November 2009

Biotransformation and Toxicokinetics
Yi M. Weaver, David J. Ehresman, John L. Butenhoff, and Bruno Hagenbuch
Roles of rat renal organic anion transporters in transporting perfluorinated carboxylates with different chain lengths
ToxSci Advance Access published on November 13, 2009.
doi:10.1093/toxsci/kfp275
[Abstract] [Accepted Manuscript] [Request Permissions]  

Biotransformation and Toxicokinetics
Lena Ernstgård, Melvin Andersen, Wolfgang Dekant, Bengt Sjögren, and Gunnar Johanson
Experimental exposure to 1,1,1,3,3-Pentafluoropropane (HFC-245fa): Uptake and disposition in humans
ToxSci Advance Access published on November 13, 2009.
doi:10.1093/toxsci/kfp273
[Abstract] [Accepted Manuscript] [Request Permissions]  

12 November 2009

Immunotoxicology
Delinda A. Johnson, Sara Amirahmadi, Charlotte Ward, Zsuszanna Fabry, and Jeffrey A. Johnson
The Absence of the Pro-Antioxidant Transcription Factor Nrf2 Exacerbates Experimental Autoimmune Encephalomyelitis
ToxSci Advance Access published on November 12, 2009.
doi:10.1093/toxsci/kfp274
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Endocrine Toxicology
Katie B. Paul, Joan M. Hedge, Michael J. DeVito, and Kevin M. Crofton
Short-term Exposure to Triclosan Decreases Thyroxine In Vivo via Upregulation of Hepatic Catabolism in Young Long-Evans Rats
ToxSci Advance Access published on November 12, 2009.
doi:10.1093/toxsci/kfp271
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Reproductive and Developmental Toxicology
Echoleah S. Rufer, Timothy A. Hacker, George R. Flentke, Victoria J. Drake, Matthew J. Brody, John Lough, and Susan M. Smith
Altered Cardiac Function and Ventricular Septal Defect in Avian Embryos Exposed to Low-Dose Trichloroethylene
ToxSci Advance Access published on November 12, 2009.
doi:10.1093/toxsci/kfp269
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

9 November 2009

Review
Helinor J. Johnston, Gary R. Hutchison, Frans M. Christensen, Karin Aschberger, and Vicki Stone
The biological mechanisms and physicochemical characteristics responsible for driving fullerene toxicity
ToxSci Advance Access published on November 9, 2009.
doi:10.1093/toxsci/kfp265
[Abstract] [Accepted Manuscript] [Request Permissions]  

3 November 2009

Molecular Toxicology
Young-Ok Son, Jeong-Chae Lee, J. Andrew Hitron, Jingju Pan, Zhuo Zhang, and Xianglin Shi
Cadmium Induces Intracellular Ca2+- and H2O2-dependent Apoptosis through JNK- and p53-mediated Pathways in Skin Epidermal Cell line
ToxSci Advance Access published on November 3, 2009.
doi:10.1093/toxsci/kfp259
[Abstract] [Accepted Manuscript] [Request Permissions]  

1 November 2009

Environmental Toxicology
Jessica C. Hervé, Doug Crump, Stephanie P. Jones, Lukas J. Mundy, John P. Giesy, Matthew J. Zwiernik, Steven J. Bursian, Paul D. Jones, Steve B. Wiseman, Yi Wan, and Sean W. Kennedy
Cytochrome P4501A induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and two chlorinated dibenzofurans in primary hepatocyte cultures of three avian species
ToxSci Advance Access published on November 1, 2009.
doi:10.1093/toxsci/kfp270
[Abstract] [Accepted Manuscript] [Request Permissions]  

Genetic Toxicology
Min Zhang, Michelle Hanna, Jia Li, Susan Butcher, Heping Dai, and Wei Xiao
Creation of a Hyper-permeable Yeast Strain to Genotoxic Agents through Combined Inactivation of PDR and CWP Genes
ToxSci Advance Access published on November 1, 2009.
doi:10.1093/toxsci/kfp267
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

30 October 2009

Respiratory Toxicology
Melanie A. Greeley, Laura S. Van Winkle, Patricia C. Edwards, and Charles G. Plopper
Airway Trefoil Factor Expression during Naphthalene Injury and Repair
ToxSci Advance Access published on October 30, 2009.
doi:10.1093/toxsci/kfp268
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

29 October 2009

Risk Assessment
Torka S. Poet, Chris R. Kirman, Michael Bader, Christoph van Thriel, Michael L. Gargas, and Paul M. Hinderliter
Quantitative Risk Analysis for N-Methyl Pyrrolidone using Physiologically Based Pharmacokinetic and Benchmark Dose Modeling
ToxSci Advance Access published on October 29, 2009.
doi:10.1093/toxsci/kfp264
[Abstract] [Accepted Manuscript] [Request Permissions]  

Reproductive and Developmental Toxicology
Heidi A Partanen, Hani S El-Nezami, Jukka M Leppänen, Päivi K Myllynen, Heather J Woodhouse, and Kirsi H Vähäkangas
Aflatoxin B1 transfer and metabolism in human placenta
ToxSci Advance Access published on October 29, 2009.
doi:10.1093/toxsci/kfp257
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Immunotoxicology
Rossi EM, Pylkkänen L, Koivisto AJ, Vippola M, Jensen KA, Miettinen M, Sirola K, Nykäsenoja H, Karisola P, Stjernvall T, Vanhala E, Kiilunen M, Pasanen P, Mäkinen M, Hämeri K, Joutsensaari J, Tuomi T, Jokiniemi J, Wolff H, Savolainen K, Matikainen S, and Alenius H
Airway exposure to silica coated TiO2 nanoparticles induces pulmonary neutrophilia in mice
ToxSci Advance Access published on October 29, 2009.
doi:10.1093/toxsci/kfp254
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

28 October 2009

Reproductive and Developmental Toxicology
Bryce C. Ryan, Andrew K. Hotchkiss, Kevin M. Crofton, and L. Earl Gray Jr
In Utero and Lactational Exposure to Bisphenol A, in contrast to Ethinyl Estradiol, Does not Alter Sexually Dimorphic Behavior, Puberty, Fertility and Anatomy of Female LE Rats
ToxSci Advance Access published on October 28, 2009.
doi:10.1093/toxsci/kfp266
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

27 October 2009

Neurotoxicology
Amy DeMicco, Keith R. Cooper, Jason R. Richardson, and Lori A. White
Developmental Neurotoxicity of Pyrethroid Insecticides in Zebrafish Embryos
ToxSci Advance Access published on October 27, 2009.
doi:10.1093/toxsci/kfp258
[Abstract] [Accepted Manuscript] [Request Permissions]  

25 October 2009

Carcinogenicity
Shugo Suzuki, Lora L. Arnold, Karen L. Pennington, Satoko Kakiuchi-Kiyota, Min Wei, Hideki Wanibuchi, and Samuel M. Cohen
Effects of Pioglitazone, a Peroxisome Proliferator-Activated Receptor Gamma Agonist, on the Urine and Urothelium of the Rat
ToxSci Advance Access published on October 25, 2009.
doi:10.1093/toxsci/kfp256
[Abstract] [Accepted Manuscript] [Request Permissions]  

Biotransformation and Toxicokinetics
Emilija Makaji, Cristina S. Trambitas, Pamela Shen, Alison C. Holloway, and Denis J. Crankshaw
Effects of cytochrome P450 inhibitors on the biotransformation of fluorogenic substrates by adult male rat liver microsomes and cDNA-expressed rat cytochrome P450 isoforms
ToxSci Advance Access published on October 25, 2009.
doi:10.1093/toxsci/kfp255
[Abstract] [Accepted Manuscript] [Request Permissions]  

22 October 2009

Carcinogenicity
Hongzu Ren, Lauren M. Aleksunes, Carmen Wood, Beena Vallanat, Michael H. George, Curtis D. Klaassen, and J. Christopher Corton
Characterization of Peroxisome Proliferator-Activated Receptor {alpha} (PPAR{alpha}) – Independent Effects of PPAR{alpha} Activators in the Rodent Liver: Di-(2-ethylhexyl) phthalate Also Activates the Constitutive Activated Receptor
ToxSci Advance Access published on October 22, 2009.
doi:10.1093/toxsci/kfp251
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

15 October 2009

Review
Michael P. Shakarjian, Diane E. Heck, Joshua P. Gray, Patrick J. Sinko, Marion K. Gordon, Robert P. Casillas, Ned D. Heindel, Donald R. Gerecke, Debra L. Laskin, and Jeffrey D. Laskin
Mechanisms Mediating the Vesicant Actions of Sulfur Mustard after Cutaneous Exposure
ToxSci Advance Access published on October 15, 2009.
doi:10.1093/toxsci/kfp253
[Abstract] [Accepted Manuscript] [Request Permissions]  

Neurotoxicology
Selva Rivas-Arancibia, Rosalinda Guevara-Guzmán, Yolanda López-Vidal, Erika Rodríguez-Martínez, Margarete Zanardo Gomes, Mariana Angoa-Pérez, and Rita Raisman-Vozari
Oxidative Stress Caused by Ozone Exposure Induces Loss of Brain Repair in The Hippocampus of Adult Rats
ToxSci Advance Access published on October 15, 2009.
doi:10.1093/toxsci/kfp252
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Environmental Toxicology
David J. Thomas, Gerardo M. Nava, Shi-Ying Cai, James L. Boyer, Araceli Hernández-Zavala, and H. Rex Gaskins
Arsenic (+3 Oxidation State) Methyltransferase and the Methylation of Arsenicals in the Invertebrate Chordate Ciona intestinalis
ToxSci Advance Access published on October 15, 2009.
doi:10.1093/toxsci/kfp250
[Abstract] [Accepted Manuscript] [Request Permissions]  

12 October 2009

Neurotoxicology
John M. Prins, Sunyoung Park, and Diana I. Lurie
Decreased expression of the voltage-dependent anion channel in differentiated PC-12 and SH-SY5Y cells following Low-level Pb exposure
ToxSci Advance Access published on October 12, 2009.
doi:10.1093/toxsci/kfp249
[Abstract] [Accepted Manuscript] [Request Permissions]  

Environmental Toxicology
Minghua Wang, Leo Lai Chan, Mengzi Si, Huasheng Hong, and Dazhi Wang
Proteomic analysis of hepatic tissue of zebrafish (Danio rerio) experimentally exposed to chronic microcystin-LR
ToxSci Advance Access published on October 12, 2009.
doi:10.1093/toxsci/kfp248
[Abstract] [Accepted Manuscript] [Request Permissions]  

Respiratory Toxicology
Jürgen Pauluhn
Subchronic 13-week Inhalation Exposure of Rats to Multiwalled Carbon Nanotubes: Toxic Effects are determined by Density of Agglomerate Structures, not fibrillar Structures
ToxSci Advance Access published on October 12, 2009.
doi:10.1093/toxsci/kfp247
[Abstract] [Accepted Manuscript] [Request Permissions]  

8 October 2009

Neurotoxicology
Carmen Vale, K. C. Nicolaou, Michael O. Frederick, Mercedes R. Vieytes, and Luis M. Botana
Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-jun-N-terminal kinase activation in cultured neurons
ToxSci Advance Access published on October 8, 2009.
doi:10.1093/toxsci/kfp246
[Abstract] [Accepted Manuscript] [Request Permissions]  

Neurotoxicology
Jeferson L. Franco, Thaís Posser, Sarah L. Gordon, Larisa Bobrovskaya, Jennifer J. Schneider, Marcelo Farina, Alcir L. Dafre, Phillip W. Dickson, and Peter R. Dunkley
Expression of Tyrosine Hydroxylase Increases the Resistance of Human Neuroblastoma Cells to Oxidative Insults
ToxSci Advance Access published on October 8, 2009.
doi:10.1093/toxsci/kfp245
[Abstract] [Accepted Manuscript] [Request Permissions]  

7 October 2009

Neurotoxicology
Victor Briz, Mireia Galofré, and Cristina Suñol
Reduction of glutamatergic neurotransmission by prolonged exposure to dieldrin involves NMDA receptor internalization and metabotropic glutamate receptor 5 down-regulation
ToxSci Advance Access published on October 7, 2009.
doi:10.1093/toxsci/kfp244
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Reproductive and Developmental Toxicology
Helen J. Badham and Louise M. Winn
In Utero Exposure to Benzene Disrupts Fetal Hematopoietic Progenitor Cell Growth Via Reactive Oxygen Species
ToxSci Advance Access published on October 7, 2009.
doi:10.1093/toxsci/kfp242
[Abstract] [Accepted Manuscript] [Request Permissions]  

Carcinogenicity
Mitscheli Sanches da Rocha, Merielen Garcia do Nascimento, Ana Paula Ferragut Cardoso, Patrícia Lepage Alves de Lima, Edneia Aparecida Zelandi, João Lauro Viana de Camargo, and Maria Luiza Cotrim Sartor de Oliveira
Cytotoxicity and Regenerative Proliferation as the Mode of Action for Diuron-Induced Urothelial Carcinogenesis in the Rat
ToxSci Advance Access published on October 7, 2009.
doi:10.1093/toxsci/kfp241
[Abstract] [Accepted Manuscript] [Request Permissions]  

Systems Toxicology
Daphna Laifenfeld, Annalyn Gilchrist, David Drubin, Milena Jorge, Sean F. Eddy, Brian P. Frushour, Bill Ladd, Leslie A. Obert, Mark M. Gosink, Jon C. Cook, Kay Criswell, Christopher J. Somps, Petra Koza-Taylor, Keith O Elliston, and Michael P. Lawton
The Role of Hypoxia in 2-Butoxyethanol-induced Hemangiosarcoma
ToxSci Advance Access published on October 7, 2009.
doi:10.1093/toxsci/kfp213
[Abstract] [Accepted Manuscript] [Supplementary Data]     OPEN ACCESS ARTICLE

6 October 2009

In Vitro Toxicology and Alternative Testing
Mathieu Solari, Joanne Paquin, Philippe Ducharme, and Monique Boily
P19 neuronal differentiation and retinoic acid metabolism as criteria to investigate atrazine, nitrite and nitrate developmental toxicity
ToxSci Advance Access published on October 6, 2009.
doi:10.1093/toxsci/kfp243
[Abstract] [Accepted Manuscript] [Request Permissions]  

Highlight
Cristina Suñol
Use of gene expression of neural markers in cultured neural cells to identify developmental neurotoxicants
ToxSci Advance Access published on October 6, 2009.
doi:10.1093/toxsci/kfp240
[Accepted Manuscript] [Request Permissions]  

5 October 2009

Genetic Toxicology
Melvin V. Limson and Kevin S. Sweder
Rapamycin inhibits yeast nucleotide excision repair independently of Tor kinases
ToxSci Advance Access published on October 5, 2009.
doi:10.1093/toxsci/kfp238
[Abstract] [Accepted Manuscript] [Request Permissions]  

4 October 2009

Immunotoxicology
Andrea Braun, Mayte Bewersdorff, Jutta Lintelmann, Georg Matuschek, Thilo Jakob, Martin Göttlicher, Wolfgang Schober, Jeroen T. M. Buters, Heidrun Behrendt, and Martin Mempel
Differential impact of diesel particle composition on pro-allergic dendritic cell function
ToxSci Advance Access published on October 4, 2009.
doi:10.1093/toxsci/kfp239
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Reproductive and Developmental Toxicology
Chad M. Vezina, Heather A. Hardin, Robert W. Moore, Sarah H. Allgeier, and Richard E. Peterson
2,3,7,8-Tetrachlorodibenzo-p-dioxin Inhibits Fibroblast Growth Factor 10-Induced Prostatic Bud Formation in Mouse Urogenital Sinus
ToxSci Advance Access published on October 4, 2009.
doi:10.1093/toxsci/kfp226
[Abstract] [Accepted Manuscript] [Request Permissions]  

Immunotoxicology
Chidozie J. Amuzie and James J. Pestka
Suppression of Insulin-Like Growth Factor Acid-Labile Subunit (IGFALS) Expression – A Novel Mechanism for Deoxynivalenol-Induced Growth Retardation
ToxSci Advance Access published on October 4, 2009.
doi:10.1093/toxsci/kfp225
[Abstract] [Accepted Manuscript] [Request Permissions]  

1 October 2009

Systems Toxicology
Abderrahim Nemmar, Suhail Al-Salam, Shaheen Zia, Javed Yasin, Isehaq Al Husseni, and Badreldin H. Ali
Diesel exhaust particles in the lung aggravate experimental acute renal failure
ToxSci Advance Access published on October 1, 2009.
doi:10.1093/toxsci/kfp222
[Abstract] [Accepted Manuscript] [Request Permissions]  

26 September 2009

Safety Evaluation
Jenny J. Fischer, Simon Michaelis, Anna K. Schrey, Olivia Baessler, Mirko Glinski, Mathias Dreger, Friedrich Kroll, and Hubert Koester
Capture Compound Mass Spectrometry (CCMS) Sheds Light on the Molecular Mechanisms of Liver Toxicity of two Parkinson Drugs
ToxSci Advance Access published on September 26, 2009.
doi:10.1093/toxsci/kfp236
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

21 September 2009

Review
Ronald N. Hines, Dana Sargent, Herman Autrup, Linda S. Birnbaum, Robert L. Brent, Nancy G. Doerrer, Elaine A. Cohen Hubal, Daland R. Juberg, Christian Laurent, Robert Luebke, Klaus Olejniczak, Christopher J. Portier, and William Slikker
Approaches for Assessing Risks to Sensitive Populations: Lessons Learned from Evaluating Risks in the Pediatric Population
ToxSci Advance Access published on September 21, 2009.
doi:10.1093/toxsci/kfp217
[Abstract] [Accepted Manuscript] [Request Permissions]  

18 September 2009

Review
A. Natsch
The Nrf2-Keap1-ARE toxicity pathway as a cellular sensor for skin sensitizers –functional relevance and a hypothesis on innate reactions to skin sensitizers
ToxSci Advance Access published on September 18, 2009.
doi:10.1093/toxsci/kfp228
[Abstract] [Accepted Manuscript] [Request Permissions]  

11 September 2009

Carcinogenicity
Moses T. Bility, Bokai Zhu, Boo Hyon Kang, Frank J. Gonzalez, and Jeffrey M. Peters
Ligand Activation of Peroxisome Proliferator-Activated Receptor-β/{delta} (PPARβ/{delta}) and Inhibition of Cyclooxygenase 2 (COX2) Enhances Inhibition of Skin Tumorigenesis
ToxSci Advance Access published on September 11, 2009.
doi:10.1093/toxsci/kfp212
[Abstract] [Accepted Manuscript] [Request Permissions]  

3 August 2009

In Vitro Toxicology and Alternative Testing
Helena T. Hogberg, Agnieszka Kinsner-Ovaskainen, Sandra Coecke, Thomas Hartung, and Anna K. Bal-Price
mRNA expression is a relevant tool to identify developmental neurotoxicants using an in vitro approach
ToxSci Advance Access published on August 3, 2009.
doi:10.1093/toxsci/kfp175
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

To see an accepted manuscript, click its [Accepted Manuscript] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.