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ToxSci Advance Access

ToxSci Advance Access articles are papers in manuscript form that have been accepted by the journal but have not been copyedited or formatted for publication. Copyediting may lead to minor differences between the Advance Access version and the final version of the paper; there may also be differences in the quality of the graphics. More information, including how to cite Advance Access papers, can be found on the Advance Access page.

Advance Access Articles By Category [View by Date]

Go to section REVIEWREVIEW
Go to section MOLECULAR TOXICOLOGYMOLECULAR TOXICOLOGY
Go to section ENVIRONMENTAL TOXICOLOGYENVIRONMENTAL TOXICOLOGY
Go to section GENETIC TOXICOLOGYGENETIC TOXICOLOGY
Go to section RESPIRATORY TOXICOLOGYRESPIRATORY TOXICOLOGY
Go to section RISK ASSESSMENTRISK ASSESSMENT
Go to section REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGYREPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY
Go to section IMMUNOTOXICOLOGYIMMUNOTOXICOLOGY
Go to section NEUROTOXICOLOGYNEUROTOXICOLOGY
Go to section CARCINOGENICITYCARCINOGENICITY
Go to section BIOTRANSFORMATION AND TOXICOKINETICSBIOTRANSFORMATION AND TOXICOKINETICS
Go to section SYSTEMS TOXICOLOGYSYSTEMS TOXICOLOGY
Go to section IN VITRO TOXICOLOGY AND ALTERNATIVE TESTINGIN VITRO TOXICOLOGY AND ALTERNATIVE TESTING
Go to section HIGHLIGHTHIGHLIGHT
Go to section FORUMFORUM
Go to section SAFETY EVALUATIONSAFETY EVALUATION
Go to section ENDOCRINE TOXICOLOGYENDOCRINE TOXICOLOGY

To see an accepted manuscript, click its [Accepted Manuscript] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

REVIEWGo to top of the page

Review
Helinor J. Johnston, Gary R. Hutchison, Frans M. Christensen, Karin Aschberger, and Vicki Stone
The biological mechanisms and physicochemical characteristics responsible for driving fullerene toxicity
ToxSci Advance Access published on November 9, 2009.
doi:10.1093/toxsci/kfp265
[Abstract] [Accepted Manuscript] [Request Permissions]  

Review
Michael P. Shakarjian, Diane E. Heck, Joshua P. Gray, Patrick J. Sinko, Marion K. Gordon, Robert P. Casillas, Ned D. Heindel, Donald R. Gerecke, Debra L. Laskin, and Jeffrey D. Laskin
Mechanisms Mediating the Vesicant Actions of Sulfur Mustard after Cutaneous Exposure
ToxSci Advance Access published on October 15, 2009.
doi:10.1093/toxsci/kfp253
[Abstract] [Accepted Manuscript] [Request Permissions]  

Review
Ronald N. Hines, Dana Sargent, Herman Autrup, Linda S. Birnbaum, Robert L. Brent, Nancy G. Doerrer, Elaine A. Cohen Hubal, Daland R. Juberg, Christian Laurent, Robert Luebke, Klaus Olejniczak, Christopher J. Portier, and William Slikker
Approaches for Assessing Risks to Sensitive Populations: Lessons Learned from Evaluating Risks in the Pediatric Population
ToxSci Advance Access published on September 21, 2009.
doi:10.1093/toxsci/kfp217
[Abstract] [Accepted Manuscript] [Request Permissions]  

Review
A. Natsch
The Nrf2-Keap1-ARE toxicity pathway as a cellular sensor for skin sensitizers –functional relevance and a hypothesis on innate reactions to skin sensitizers
ToxSci Advance Access published on September 18, 2009.
doi:10.1093/toxsci/kfp228
[Abstract] [Accepted Manuscript] [Request Permissions]  

Review
Jennifer L. Pelley, Abdallah S. Daar, and Marc A. Saner
State of Academic Knowledge on Toxicity and Biological Fate of Quantum Dots
ToxSci Advance Access published on August 14, 2009.
doi:10.1093/toxsci/kfp188
[Abstract] [Accepted Manuscript]     OPEN ACCESS ARTICLE

MOLECULAR TOXICOLOGYGo to top of the page

Molecular Toxicology
Young-Ok Son, Jeong-Chae Lee, J. Andrew Hitron, Jingju Pan, Zhuo Zhang, and Xianglin Shi
Cadmium Induces Intracellular Ca2+- and H2O2-dependent Apoptosis through JNK- and p53-mediated Pathways in Skin Epidermal Cell line
ToxSci Advance Access published on November 3, 2009.
doi:10.1093/toxsci/kfp259
[Abstract] [Accepted Manuscript] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGYGo to top of the page

Environmental Toxicology
Jessica C. Hervé, Doug Crump, Stephanie P. Jones, Lukas J. Mundy, John P. Giesy, Matthew J. Zwiernik, Steven J. Bursian, Paul D. Jones, Steve B. Wiseman, Yi Wan, and Sean W. Kennedy
Cytochrome P4501A induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and two chlorinated dibenzofurans in primary hepatocyte cultures of three avian species
ToxSci Advance Access published on November 1, 2009.
doi:10.1093/toxsci/kfp270
[Abstract] [Accepted Manuscript] [Request Permissions]  

Environmental Toxicology
David J. Thomas, Gerardo M. Nava, Shi-Ying Cai, James L. Boyer, Araceli Hernández-Zavala, and H. Rex Gaskins
Arsenic (+3 Oxidation State) Methyltransferase and the Methylation of Arsenicals in the Invertebrate Chordate Ciona intestinalis
ToxSci Advance Access published on October 15, 2009.
doi:10.1093/toxsci/kfp250
[Abstract] [Accepted Manuscript] [Request Permissions]  

Environmental Toxicology
Minghua Wang, Leo Lai Chan, Mengzi Si, Huasheng Hong, and Dazhi Wang
Proteomic analysis of hepatic tissue of zebrafish (Danio rerio) experimentally exposed to chronic microcystin-LR
ToxSci Advance Access published on October 12, 2009.
doi:10.1093/toxsci/kfp248
[Abstract] [Accepted Manuscript] [Request Permissions]  

Environmental Toxicology
Young-Mi Go, Siobhan E. Craige, Michael Orr, Kim M. Gernert, and Dean P. Jones
Gene and Protein Responses of Human Monocytes to Extracellular Cysteine Redox Potential
ToxSci Advance Access published on September 11, 2009.
doi:10.1093/toxsci/kfp205
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

GENETIC TOXICOLOGYGo to top of the page

Genetic Toxicology
Min Zhang, Michelle Hanna, Jia Li, Susan Butcher, Heping Dai, and Wei Xiao
Creation of a Hyper-permeable Yeast Strain to Genotoxic Agents through Combined Inactivation of PDR and CWP Genes
ToxSci Advance Access published on November 1, 2009.
doi:10.1093/toxsci/kfp267
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Genetic Toxicology
Melvin V. Limson and Kevin S. Sweder
Rapamycin inhibits yeast nucleotide excision repair independently of Tor kinases
ToxSci Advance Access published on October 5, 2009.
doi:10.1093/toxsci/kfp238
[Abstract] [Accepted Manuscript] [Request Permissions]  

RESPIRATORY TOXICOLOGYGo to top of the page

Respiratory Toxicology
Melanie A. Greeley, Laura S. Van Winkle, Patricia C. Edwards, and Charles G. Plopper
Airway Trefoil Factor Expression during Naphthalene Injury and Repair
ToxSci Advance Access published on October 30, 2009.
doi:10.1093/toxsci/kfp268
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Respiratory Toxicology
Jürgen Pauluhn
Subchronic 13-week Inhalation Exposure of Rats to Multiwalled Carbon Nanotubes: Toxic Effects are determined by Density of Agglomerate Structures, not fibrillar Structures
ToxSci Advance Access published on October 12, 2009.
doi:10.1093/toxsci/kfp247
[Abstract] [Accepted Manuscript] [Request Permissions]  

Respiratory Toxicology
Christine Pohl, Mirko Papritz, Michaela Moisch, Christoph Wübbecke, M. Iris Hermanns, Chiara Uboldi, Jasmin Dei-Anang, Eckhard Mayer, Charles James Kirkpatrick, and Kai Kehe
Acute Morphological and Toxicological Effects in a Human Bronchial Coculture Model after Sulphur Mustard Exposure
ToxSci Advance Access published on September 11, 2009.
doi:10.1093/toxsci/kfp211
[Abstract] [Accepted Manuscript] [Request Permissions]  

Respiratory Toxicology
Lan Ma-Hock, Silke Treumann, Volker Strauss, Sandra Brill, Frederic Luizi, Michael Mertler, Karin Wiench, Armin O. Gamer, Bennard van Ravenzwaay, and Robert Landsiedel
INHALATION TOXICITY OF MULTI-WALL CARBON NANOTUBES IN RATS EXPOSED FOR 3 MONTHS
ToxSci Advance Access published on July 7, 2009.
doi:10.1093/toxsci/kfp146
[Abstract] [Accepted Manuscript] [Request Permissions]  

RISK ASSESSMENTGo to top of the page

Risk Assessment
Torka S. Poet, Chris R. Kirman, Michael Bader, Christoph van Thriel, Michael L. Gargas, and Paul M. Hinderliter
Quantitative Risk Analysis for N-Methyl Pyrrolidone using Physiologically Based Pharmacokinetic and Benchmark Dose Modeling
ToxSci Advance Access published on October 29, 2009.
doi:10.1093/toxsci/kfp264
[Abstract] [Accepted Manuscript] [Request Permissions]  

Risk Assessment
Ted Simon, Lesa L. Aylward, Christopher R. Kirman, J. Craig Rowlands, and Robert A. Budinsky
Estimates of Cancer Potency of 2,3,7,8-Tetrachlorodibenzo(p)dioxin using Linear and Non-linear Dose-Response Modeling and Toxicokinetics
ToxSci Advance Access published on September 23, 2009.
doi:10.1093/toxsci/kfp232
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGYGo to top of the page

Reproductive and Developmental Toxicology
Heidi A Partanen, Hani S El-Nezami, Jukka M Leppänen, Päivi K Myllynen, Heather J Woodhouse, and Kirsi H Vähäkangas
Aflatoxin B1 transfer and metabolism in human placenta
ToxSci Advance Access published on October 29, 2009.
doi:10.1093/toxsci/kfp257
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Reproductive and Developmental Toxicology
Bryce C. Ryan, Andrew K. Hotchkiss, Kevin M. Crofton, and L. Earl Gray Jr
In Utero and Lactational Exposure to Bisphenol A, in contrast to Ethinyl Estradiol, Does not Alter Sexually Dimorphic Behavior, Puberty, Fertility and Anatomy of Female LE Rats
ToxSci Advance Access published on October 28, 2009.
doi:10.1093/toxsci/kfp266
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Reproductive and Developmental Toxicology
Helen J. Badham and Louise M. Winn
In Utero Exposure to Benzene Disrupts Fetal Hematopoietic Progenitor Cell Growth Via Reactive Oxygen Species
ToxSci Advance Access published on October 7, 2009.
doi:10.1093/toxsci/kfp242
[Abstract] [Accepted Manuscript] [Request Permissions]  

Reproductive and Developmental Toxicology
Chad M. Vezina, Heather A. Hardin, Robert W. Moore, Sarah H. Allgeier, and Richard E. Peterson
2,3,7,8-Tetrachlorodibenzo-p-dioxin Inhibits Fibroblast Growth Factor 10-Induced Prostatic Bud Formation in Mouse Urogenital Sinus
ToxSci Advance Access published on October 4, 2009.
doi:10.1093/toxsci/kfp226
[Abstract] [Accepted Manuscript] [Request Permissions]  

Reproductive and Developmental Toxicology
Kenneth A. Voss, Ronald T. Riley, Maurice E. Snook, and Janee Gelineau-van Waes
Reproductive and Sphingolipid Metabolic Effects of Fumonisin B1 and its Alkaline Hydrolysis Product in LM/Bc Mice: Hydrolyzed Fumonisin B1 Did Not Cause Neural Tube Defects
ToxSci Advance Access published on September 25, 2009.
doi:10.1093/toxsci/kfp215
[Abstract] [Accepted Manuscript] [Request Permissions]  

Reproductive and Developmental Toxicology
Ruchna Verma and Banalata Mohanty
Early life exposure to Dimethoate induced Reproductive toxicity: Evaluation of effects on Pituitary-testicular axis of mice
ToxSci Advance Access published on September 2, 2009.
doi:10.1093/toxsci/kfp204
[Abstract] [Accepted Manuscript] [Request Permissions]  

IMMUNOTOXICOLOGYGo to top of the page

Immunotoxicology
Rossi EM, Pylkkänen L, Koivisto AJ, Vippola M, Jensen KA, Miettinen M, Sirola K, Nykäsenoja H, Karisola P, Stjernvall T, Vanhala E, Kiilunen M, Pasanen P, Mäkinen M, Hämeri K, Joutsensaari J, Tuomi T, Jokiniemi J, Wolff H, Savolainen K, Matikainen S, and Alenius H
Airway exposure to silica coated TiO2 nanoparticles induces pulmonary neutrophilia in mice
ToxSci Advance Access published on October 29, 2009.
doi:10.1093/toxsci/kfp254
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Immunotoxicology
Andrea Braun, Mayte Bewersdorff, Jutta Lintelmann, Georg Matuschek, Thilo Jakob, Martin Göttlicher, Wolfgang Schober, Jeroen T. M. Buters, Heidrun Behrendt, and Martin Mempel
Differential impact of diesel particle composition on pro-allergic dendritic cell function
ToxSci Advance Access published on October 4, 2009.
doi:10.1093/toxsci/kfp239
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Immunotoxicology
Chidozie J. Amuzie and James J. Pestka
Suppression of Insulin-Like Growth Factor Acid-Labile Subunit (IGFALS) Expression – A Novel Mechanism for Deoxynivalenol-Induced Growth Retardation
ToxSci Advance Access published on October 4, 2009.
doi:10.1093/toxsci/kfp225
[Abstract] [Accepted Manuscript] [Request Permissions]  

Immunotoxicology
Haitian Lu, Robert B. Crawford, Colin M. North, Barbara L.F. Kaplan, and Norbert E. Kaminski
Establishment of an Immunoglobulin M Antibody Forming Cell Response Model for Characterizing Immunotoxicity in Primary Human B Cells
ToxSci Advance Access published on September 18, 2009.
doi:10.1093/toxsci/kfp224
[Abstract] [Accepted Manuscript] [Request Permissions]  

NEUROTOXICOLOGYGo to top of the page

Neurotoxicology
Amy DeMicco, Keith R. Cooper, Jason R. Richardson, and Lori A. White
Developmental Neurotoxicity of Pyrethroid Insecticides in Zebrafish Embryos
ToxSci Advance Access published on October 27, 2009.
doi:10.1093/toxsci/kfp258
[Abstract] [Accepted Manuscript] [Request Permissions]  

Neurotoxicology
Selva Rivas-Arancibia, Rosalinda Guevara-Guzmán, Yolanda López-Vidal, Erika Rodríguez-Martínez, Margarete Zanardo Gomes, Mariana Angoa-Pérez, and Rita Raisman-Vozari
Oxidative Stress Caused by Ozone Exposure Induces Loss of Brain Repair in The Hippocampus of Adult Rats
ToxSci Advance Access published on October 15, 2009.
doi:10.1093/toxsci/kfp252
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Neurotoxicology
John M. Prins, Sunyoung Park, and Diana I. Lurie
Decreased expression of the voltage-dependent anion channel in differentiated PC-12 and SH-SY5Y cells following Low-level Pb exposure
ToxSci Advance Access published on October 12, 2009.
doi:10.1093/toxsci/kfp249
[Abstract] [Accepted Manuscript] [Request Permissions]  

Neurotoxicology
Carmen Vale, K. C. Nicolaou, Michael O. Frederick, Mercedes R. Vieytes, and Luis M. Botana
Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-jun-N-terminal kinase activation in cultured neurons
ToxSci Advance Access published on October 8, 2009.
doi:10.1093/toxsci/kfp246
[Abstract] [Accepted Manuscript] [Request Permissions]  

Neurotoxicology
Jeferson L. Franco, Thaís Posser, Sarah L. Gordon, Larisa Bobrovskaya, Jennifer J. Schneider, Marcelo Farina, Alcir L. Dafre, Phillip W. Dickson, and Peter R. Dunkley
Expression of Tyrosine Hydroxylase Increases the Resistance of Human Neuroblastoma Cells to Oxidative Insults
ToxSci Advance Access published on October 8, 2009.
doi:10.1093/toxsci/kfp245
[Abstract] [Accepted Manuscript] [Request Permissions]  

Neurotoxicology
Victor Briz, Mireia Galofré, and Cristina Suñol
Reduction of glutamatergic neurotransmission by prolonged exposure to dieldrin involves NMDA receptor internalization and metabotropic glutamate receptor 5 down-regulation
ToxSci Advance Access published on October 7, 2009.
doi:10.1093/toxsci/kfp244
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Neurotoxicology
Julie A. Moreno, Karin M. Streifel, Kelly A. Sullivan, Marie E. Legare, and Ronald B. Tjalkens
Developmental exposure to manganese (Mn) increases adult susceptibility to inflammatory activation of glia and neuronal protein nitration
ToxSci Advance Access published on October 7, 2009.
doi:10.1093/toxsci/kfp221
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Neurotoxicology
Julie A. Moreno, Elizabeth C. Yeomans, Karin M. Streifel, Bryan L. Brattin, Robert J. Taylor, and Ronald B. Tjalkens
Age-dependent susceptibility to manganese-induced neurological dysfunction
ToxSci Advance Access published on October 7, 2009.
doi:10.1093/toxsci/kfp220
[Abstract] [Accepted Manuscript] [Supplementary Data]     OPEN ACCESS ARTICLE

Neurotoxicology
Marcelo Farina, Francisco Campos, Iolanda Vendrell, Jordi Berenguer, Mercedes Barzi, Sebastián Pons, and Cristina Suñol
Probucol Increases Glutathione Peroxidase-1 Activity and Displays Long-Lasting Protection Against Methylmercury Toxicity in Cerebellar Granule Cells
ToxSci Advance Access published on September 21, 2009.
doi:10.1093/toxsci/kfp219
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Neurotoxicology
Hyung Gyun Kim, Yong Pil Hwang, Eun Hee Han, Chul Yung Choi, Chang-Yeol Yeo, Jin Young Kim, Kwang Youl Lee, and Hye Gwang Jeong
Metallothionein-III provides neuronal protection through activation of Nuclear Factor-{kappa}B via the TrkA/Phosphatidylinositol-3 kinase/Akt signaling pathway
ToxSci Advance Access published on September 18, 2009.
doi:10.1093/toxsci/kfp230
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Neurotoxicology
Derek A. Drechsel and Manisha Patel
Differential contribution of the mitochondrial respiratory chain complexes to reactive oxygen species production by redox cycling agents implicated in parkinsonism
ToxSci Advance Access published on September 18, 2009.
doi:10.1093/toxsci/kfp223
[Abstract] [Accepted Manuscript]     OPEN ACCESS ARTICLE

CARCINOGENICITYGo to top of the page

Carcinogenicity
Shugo Suzuki, Lora L. Arnold, Karen L. Pennington, Satoko Kakiuchi-Kiyota, Min Wei, Hideki Wanibuchi, and Samuel M. Cohen
Effects of Pioglitazone, a Peroxisome Proliferator-Activated Receptor Gamma Agonist, on the Urine and Urothelium of the Rat
ToxSci Advance Access published on October 25, 2009.
doi:10.1093/toxsci/kfp256
[Abstract] [Accepted Manuscript] [Request Permissions]  

Carcinogenicity
Hongzu Ren, Lauren M. Aleksunes, Carmen Wood, Beena Vallanat, Michael H. George, Curtis D. Klaassen, and J. Christopher Corton
Characterization of Peroxisome Proliferator-Activated Receptor {alpha} (PPAR{alpha}) – Independent Effects of PPAR{alpha} Activators in the Rodent Liver: Di-(2-ethylhexyl) phthalate Also Activates the Constitutive Activated Receptor
ToxSci Advance Access published on October 22, 2009.
doi:10.1093/toxsci/kfp251
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Carcinogenicity
Mitscheli Sanches da Rocha, Merielen Garcia do Nascimento, Ana Paula Ferragut Cardoso, Patrícia Lepage Alves de Lima, Edneia Aparecida Zelandi, João Lauro Viana de Camargo, and Maria Luiza Cotrim Sartor de Oliveira
Cytotoxicity and Regenerative Proliferation as the Mode of Action for Diuron-Induced Urothelial Carcinogenesis in the Rat
ToxSci Advance Access published on October 7, 2009.
doi:10.1093/toxsci/kfp241
[Abstract] [Accepted Manuscript] [Request Permissions]  

Carcinogenicity
Hung-Chi Lin, Tuzz-Ying Song, and Miao-Lin Hu
S-Adenosylhomocysteine Promotes the Invasion of C6 Glioma Cells via Increased Secretion of Matrix Metalloproteinase-2 in Murine Microglial BV2 Cells
ToxSci Advance Access published on September 26, 2009.
doi:10.1093/toxsci/kfp218
[Abstract] [Accepted Manuscript] [Request Permissions]  

Carcinogenicity
Russell S. Thomas, Wenjun Bao, Tzu-Ming Chu, Marina Bessarabova, Tatiana Nikolskaya, Yuri Nikolsky, Melvin E. Andersen, and Russell D. Wolfinger
Use of Short-term Transcriptional Profiles to Assess the Long-term Cancer-Related Safety of Environmental and Industrial Chemicals
ToxSci Advance Access published on September 23, 2009.
doi:10.1093/toxsci/kfp233
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Carcinogenicity
Kerstin Gross-Steinmeyer, Patricia L. Stapleton, Julia H. Tracy, Theo K. Bammler, Stephen C. Strom, Donald R. Buhler, and David L. Eaton
Modulation of aflatoxin B1-mediated genotoxicity in primary cultures of human hepatocytes by diindolylmethane, curcumin and xanthohumols
ToxSci Advance Access published on September 21, 2009.
doi:10.1093/toxsci/kfp206
[Abstract] [Accepted Manuscript] [Request Permissions]  

Carcinogenicity
Moses T. Bility, Bokai Zhu, Boo Hyon Kang, Frank J. Gonzalez, and Jeffrey M. Peters
Ligand Activation of Peroxisome Proliferator-Activated Receptor-β/{delta} (PPARβ/{delta}) and Inhibition of Cyclooxygenase 2 (COX2) Enhances Inhibition of Skin Tumorigenesis
ToxSci Advance Access published on September 11, 2009.
doi:10.1093/toxsci/kfp212
[Abstract] [Accepted Manuscript] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICSGo to top of the page

Biotransformation and Toxicokinetics
Emilija Makaji, Cristina S. Trambitas, Pamela Shen, Alison C. Holloway, and Denis J. Crankshaw
Effects of cytochrome P450 inhibitors on the biotransformation of fluorogenic substrates by adult male rat liver microsomes and cDNA-expressed rat cytochrome P450 isoforms
ToxSci Advance Access published on October 25, 2009.
doi:10.1093/toxsci/kfp255
[Abstract] [Accepted Manuscript] [Request Permissions]  

SYSTEMS TOXICOLOGYGo to top of the page

Systems Toxicology
Daphna Laifenfeld, Annalyn Gilchrist, David Drubin, Milena Jorge, Sean F. Eddy, Brian P. Frushour, Bill Ladd, Leslie A. Obert, Mark M. Gosink, Jon C. Cook, Kay Criswell, Christopher J. Somps, Petra Koza-Taylor, Keith O Elliston, and Michael P. Lawton
The Role of Hypoxia in 2-Butoxyethanol-induced Hemangiosarcoma
ToxSci Advance Access published on October 7, 2009.
doi:10.1093/toxsci/kfp213
[Abstract] [Accepted Manuscript] [Supplementary Data]     OPEN ACCESS ARTICLE

Systems Toxicology
Abderrahim Nemmar, Suhail Al-Salam, Shaheen Zia, Javed Yasin, Isehaq Al Husseni, and Badreldin H. Ali
Diesel exhaust particles in the lung aggravate experimental acute renal failure
ToxSci Advance Access published on October 1, 2009.
doi:10.1093/toxsci/kfp222
[Abstract] [Accepted Manuscript] [Request Permissions]  

Systems Toxicology
Mehdi S. Hazari, Najwa Haykal-Coates, Darrell W. Winsett, Daniel L. Costa, and Aimen K. Farraj
A single exposure to particulate or gaseous air pollution increases the risk of aconitine-induced cardiac arrhythmia in hypertensive rats
ToxSci Advance Access published on September 11, 2009.
doi:10.1093/toxsci/kfp214
[Abstract] [Accepted Manuscript] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTINGGo to top of the page

In Vitro Toxicology and Alternative Testing
Mathieu Solari, Joanne Paquin, Philippe Ducharme, and Monique Boily
P19 neuronal differentiation and retinoic acid metabolism as criteria to investigate atrazine, nitrite and nitrate developmental toxicity
ToxSci Advance Access published on October 6, 2009.
doi:10.1093/toxsci/kfp243
[Abstract] [Accepted Manuscript] [Request Permissions]  

In Vitro Toxicology and Alternative Testing
Ruili Huang, Noel Southall, Menghang Xia, Ming-Hsuang Cho, Ajit Jadhav, Dac-Trung Nguyen, James Inglese, Raymond R. Tice, and Christopher P. Austin
Weighted Feature Significance (WFS): A Simple, Interpretable Model of Compound Toxicity Based on the Statistical Enrichment of Structural Features
ToxSci Advance Access published on October 4, 2009.
doi:10.1093/toxsci/kfp231
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

In Vitro Toxicology and Alternative Testing
K. Mathijs, K.J. Brauers, D.G.J. Jennen, A. Boorsma, M.H.M. van Herwijnen, R.W.H. Gottschalk, J.C.S. Kleinjans, and J.H.M. van Delft
Discrimination for genotoxic and non-genotoxic carcinogens by gene expression profiling in primary mouse hepatocytes improves with exposure time
ToxSci Advance Access published on September 21, 2009.
doi:10.1093/toxsci/kfp229
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

In Vitro Toxicology and Alternative Testing
Helena T. Hogberg, Agnieszka Kinsner-Ovaskainen, Sandra Coecke, Thomas Hartung, and Anna K. Bal-Price
mRNA expression is a relevant tool to identify developmental neurotoxicants using an in vitro approach
ToxSci Advance Access published on August 3, 2009.
doi:10.1093/toxsci/kfp175
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

HIGHLIGHTGo to top of the page

Highlight
Cristina Suñol
Use of gene expression of neural markers in cultured neural cells to identify developmental neurotoxicants
ToxSci Advance Access published on October 6, 2009.
doi:10.1093/toxsci/kfp240
[Accepted Manuscript] [Request Permissions]  

Highlight
David B. Warheit
Long-term Inhalation Toxicity Studies with Multi-walled Carbon Nanotubes: Closing the Gaps or Initiating the Debate?
ToxSci Advance Access published on September 26, 2009.
doi:10.1093/toxsci/kfp237
[Accepted Manuscript] [Request Permissions]  

FORUMGo to top of the page

Forum
James S. Bus and Richard A. Becker
"Toxicity Testing in the 21st Century: A View from the Chemical Industry
ToxSci Advance Access published on October 4, 2009.
doi:10.1093/toxsci/kfp234
[Accepted Manuscript] [Request Permissions]  

SAFETY EVALUATIONGo to top of the page

Safety Evaluation
Jenny J. Fischer, Simon Michaelis, Anna K. Schrey, Olivia Baessler, Mirko Glinski, Mathias Dreger, Friedrich Kroll, and Hubert Koester
Capture Compound Mass Spectrometry (CCMS) Sheds Light on the Molecular Mechanisms of Liver Toxicity of two Parkinson Drugs
ToxSci Advance Access published on September 26, 2009.
doi:10.1093/toxsci/kfp236
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Safety Evaluation
D. J. Antoine, D. P. Williams, A. Kipar, R. E. Jenkins, S. L. Regan, J. G. Sathish, N. R. Kitteringham, and B. K. Park
High Mobility Group Box-1 protein and Keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo
ToxSci Advance Access published on September 25, 2009.
doi:10.1093/toxsci/kfp235
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Safety Evaluation
Nora Anderson, Tatjana Meier, and Jürgen Borlak
Toxicogenomics applied to cultures of human hepatocytes enabled an identification of novel petasites hybridus extracts for the treatment of migraine with improved hepatobiliary safety
ToxSci Advance Access published on September 21, 2009.
doi:10.1093/toxsci/kfp216
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ENDOCRINE TOXICOLOGYGo to top of the page

Endocrine Toxicology
Gerald T. Ankley, David C. Bencic, Jenna E. Cavallin, Kathleen M. Jensen, Michael D. Kahl, Elizabeth A. Makynen, Dalma Martinovic, Nathaniel D. Mueller, Leah C. Wehmas, and Daniel L. Villeneuve
Dynamic Nature of Alterations in the Endocrine System of Fathead Minnows Exposed to the Fungicide Prochloraz
ToxSci Advance Access published on September 18, 2009.
doi:10.1093/toxsci/kfp227
[Abstract] [Accepted Manuscript] [Supplementary Data] [Request Permissions]  

Endocrine Toxicology
E Mathews, TD Braden, CS Williams, JW Williams, O Bolden-Tiller, and H O Goyal
Mal-development of the Penis and Loss of Fertility in Male Rats Treated Neonatally with Female Contraceptive 17{alpha}-Ethinyl Estradiol (EE). A Dose-response Study and a Comparative Study with a Known Estrogenic Teratogen Diethylstilbestrol (DES)
ToxSci Advance Access published on September 3, 2009.
doi:10.1093/toxsci/kfp207
[Abstract] [Accepted Manuscript] [Request Permissions]  

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